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| 61行目: | 61行目: | ||
''詳細は[[NMDA型グルタミン酸受容体]]の項目参照'' | ''詳細は[[NMDA型グルタミン酸受容体]]の項目参照'' | ||
{| class="wikitable" | |||
|- | |||
! Mammalian receptor family | |||
! Subunit | |||
(Old nomenclature) | |||
! Gene | |||
! Chromosome<br/>(human) | |||
|- | |||
| rowspan="4" align="center" | [[AMPA receptor|AMPA]] | |||
| GluA1 (GluR<sub>1</sub>) | |||
| ''[[GRIA1]]'' | |||
| align="center" | 5q33 | |||
|- | |||
| GluA2 (GluR<sub>2</sub>) | |||
| ''[[GRIA2]]'' | |||
| align="center" | 4q32-33 | |||
|- | |||
| GluA3 (GluR<sub>3</sub>) | |||
| ''[[GRIA3]]'' | |||
| align="center" | Xq25-26 | |||
|- | |||
| GluA4 (GluR<sub>4</sub>) | |||
| ''[[GRIA4]]'' | |||
| align="center" | 11q22-23 | |||
|- | |||
| rowspan="5" align="center" | [[Kainate receptor|Kainate]] | |||
| GluK1 (GluR<sub>5</sub>) | |||
| ''[[GRIK1]]'' | |||
| align="center" | 21q21.1-22.1 | |||
|- | |||
| GluK2 (GluR<sub>6</sub>) | |||
| ''[[GRIK2]]'' | |||
| align="center" | 6q16.3-q21 | |||
|- | |||
| GluK3 (GluR<sub>7</sub>) | |||
| ''[[GRIK3]]'' | |||
| align="center" | 1p34-p33 | |||
|- | |||
| GluK4 (KA-1) | |||
| ''[[GRIK4]]'' | |||
| align="center" | 11q22.3 | |||
|- | |||
| GluK5 (KA-2) | |||
| ''[[GRIK5]]'' | |||
| align="center" | 19q13.2 | |||
|- | |||
| rowspan="7" align="center" | [[NMDA receptor|NMDA]] | |||
| GluN1(NR1) | |||
| ''[[GRIN1]]'' | |||
| align="center" | 9q34.3 | |||
|- | |||
| GluN2A (NR2A) | |||
| ''[[GRIN2A]]'' | |||
| align="center" | 16p13.2 | |||
|- | |||
| GluN2B (NR2B) | |||
| ''[[GRIN2B]]'' | |||
| align="center" | 12p12 | |||
|- | |||
| GluN2C (NR2C) | |||
| ''[[GRIN2C]]'' | |||
| align="center" | 17q24-q25 | |||
|- | |||
| GluN2D (NR2D) | |||
| ''[[GRIN2D]]'' | |||
| align="center" | 19q13.1qter | |||
|- | |||
| GluN3A (NR3A) | |||
| ''[[GRIN3A]]'' | |||
| align="center" | 9q31.1 | |||
|- | |||
| GluN3B (NR3B) | |||
| ''[[GRIN3B]]'' | |||
| align="center" | 19p13.3 | |||
|} | |||
==代謝活性型グルタミン酸受容体== | ==代謝活性型グルタミン酸受容体== | ||
| 75行目: | 152行目: | ||
===サブグループIII=== | ===サブグループIII=== | ||
[[L-AP4|<small>L</small>−AP4]]により活性化され、cAMP産生を抑制する。また、サブグループIIと同様にGIRKを活性化する。[[mGluR4]]、[[mGluR6]]、[[mGluR7]]、[[mGluR8]]が属する。 | [[L-AP4|<small>L</small>−AP4]]により活性化され、cAMP産生を抑制する。また、サブグループIIと同様にGIRKを活性化する。[[mGluR4]]、[[mGluR6]]、[[mGluR7]]、[[mGluR8]]が属する。 | ||
{| class="wikitable" | |||
|- | |||
! Group | |||
! Receptor | |||
! Gene | |||
! Chromosome<br/>(human) | |||
! Effect | |||
|- | |||
| rowspan="2" align="center" | 1 | |||
| mGluR<sub>1</sub> | |||
| ''[[Metabotropic glutamate receptor 1|GRM1]]'' | |||
| align="center" | 6q24 | |||
| Increase in Ca<sup>2+</sup> concentration in the cytoplasm. | |||
|- | |||
| mGluR<sub>5</sub> | |||
| ''[[Metabotropic glutamate receptor 5|GRM5]]'' | |||
| align="center" | 11q14.3 | |||
| Release of K<sup>+</sup> from the cell by activating K<sup>+</sup> ionic channels | |||
|- | |||
| rowspan="2" align="center" | 2 | |||
| mGluR<sub>2</sub> | |||
| ''[[Metabotropic glutamate receptor 2|GRM2]]'' | |||
| align="center" | 3p21.2 | |||
| rowspan="2" | Inhibition of [[adenylyl cyclase]] causing shutdown of the [[cAMP-dependent pathway]]<br />And therefore decreasing amount of [[cyclic adenosine monophosphate|cAMP]] | |||
|- | |||
| mGluR<sub>3</sub> | |||
| ''[[GRM3]]'' | |||
| align="center" | 7q21.1-q21.2 | |||
|- | |||
| rowspan="4" align="center" | 3 | |||
| mGluR<sub>4</sub> | |||
| ''[[Metabotropic glutamate receptor 4|GRM4]]'' | |||
| align="center" | 6p21.3 | |||
| rowspan="4" | Activation of Ca<sup>2+</sup> channels, allowing more Ca<sup>2+</sup> to enter the cell<ref name="con1">{{cite journal | author = Conn PJ et al. | title = Metabotropic glutamate receptors in the basal ganglia motor circuit | journal = Nature Reviews Neuroscience | volume = 6 | issue = 10 | pages = 787–98 | year = 2005 | pmid = 16276355 | doi = 10.1038/nrn1763}}</ref> | |||
|- | |||
| mGluR<sub>6</sub> | |||
| ''[[Metabotropic glutamate receptor 6|GRM6]]'' | |||
| align="center" | 5q35 | |||
|- | |||
| mGluR<sub>7</sub> | |||
| ''[[Metabotropic glutamate receptor 7|GRM7]]'' | |||
| align="center" | 3p26-p25 | |||
|- | |||
| mGluR<sub>8</sub> | |||
| ''[[Metabotropic glutamate receptor 8|GRM8]]'' | |||
| align="center" | 7q31.3-q32.1 | |||
|} | |||
==関連項目== | ==関連項目== | ||