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ヒスタミン

2,311 バイト追加, 2018年3月14日 (水) 22:34
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英語名:histamine 独:histamin 仏:histamine<br />
IUPAC 名 : 2-(1H-imidazol-4-yl)ethanamine<br />別称:1H-Imidazole-5-ethanamine、2-(4-Imidazolyl)ethanamine、2-(1H-Imidazol-4-yl)ethylamine 、2-(1H-Imidazol-5-yl)ethylamine、β-Imidazolyl-4-ethylamine
{{box|text= ヒスタミンは生体内で、アミノ酸であるヒスチジンから合成される。末梢では主に肥満細胞に貯えられ、刺激に応じて放出されアレルギー反応に関与する。また、摂食によってエンテロクロマフィン様細胞から遊離され、胃酸分泌に関与する。中枢では、視床下部乳頭体にヒスタミンニューロンが集まっており、そこから脳内各部位に投射し、神経伝達物質として働いている。睡眠・覚醒、摂食調節などに関与している。}}
{{chembox
| Verifiedimages = changed
| Watchedfields = changed
| verifiedrevid = 443858090
| ImageFile_Ref = {{chemboximage|correct|??}}
| ImageFile = Histamine.svg
| ImageSize =
| ImageFile2 = Histamine 3D ball.png
| ImageSize2 =
| IUPACName = 2-(1''H''-Imidazol-4-yl)ethanamine
| OtherNames =1H-Imidazole-5-ethanamine, 2-(4-Imidazolyl)ethanamine, 2-(1H-Imidazol-4-yl)ethylamine , 2-(1H-Imidazol-5-yl)ethylamine, β-Imidazolyl-4-ethylamine
 
|Section1 = {{Chembox Identifiers
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 820484N8I3
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D08040
| InChI = 1/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
| InChIKey = NTYJJOPFIAHURM-UHFFFAOYAP
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 90
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = NTYJJOPFIAHURM-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 51-45-6
| PubChem = 774
| IUPHAR_ligand = 1204
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 753
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 18295
| SMILES = NCCC1=C[N]C=N1
| MeSHName=Histamine
}}
 
|Section2 = {{Chembox Properties
| C=5 | H=9 | N=3
| Appearance=
| Density=
| MeltingPtC= 83.5
| BoilingPtC= 209.5
| LogP = −0.7<ref name=Vuckovic>{{cite journal|last1=Vuckovic|first1=Dajana|last2=Pawliszyn|first2=Janusz|title=Systematic Evaluation of Solid-Phase Microextraction Coatings for Untargeted Metabolomic Profiling of Biological Fluids by Liquid Chromatography−Mass Spectrometry|journal=Analytical Chemistry|date=15 March 2011|volume=83|issue=6|pages=1944–1954|doi=10.1021/ac102614v|location=Supporting Information|pmid=21332182}}</ref>
| pKa = [[Imidazole]]: 6.04 <BR> Terminal NH<sub>2</sub>: 9.75<ref name=Vuckovic />
| Solubility = Easily soluble in cold water, hot water<ref name="sciencelab.com">{{cite techreport |title=Histamine Material Safety Data Sheet |institution=sciencelab.com |date=2013-05-21 |url=http://www.sciencelab.com/msds.php?msdsId=9924264}}</ref>
| SolubleOther = Easily soluble in methanol. Very slightly soluble in diethyl ether.<ref name="sciencelab.com"/> Easily soluble in ethanol.
| Solvent = other solvents
}}
|Section6 = {{Chembox Pharmacology
| ATCCode_prefix = L03
| ATCCode_suffix = AX14
| ATC_Supplemental = {{ATC|V04|CG03}} (phosphate)
}}
|Section7 = {{Chembox Hazards
| MainHazards =
| FlashPt =
| AutoignitionPt =
}}
}}
== 発見 ==

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