16,039
回編集
「セリンラセミ化酵素」の版間の差分
ナビゲーションに移動
検索に移動
細
編集の要約なし
細編集の要約なし |
細編集の要約なし |
||
| 1行目: | 1行目: | ||
英：serine | {{GNF_Protein_box | ||
| Name = Serine racemase | |||
| image = Crystal_structure_of_serine_racemase_3hmk.png | |||
| image_source = Rendering based on 3hmk | |||
| PDB = {{PDB2|3L6B}}, {{PDB2|3L6R}} | |||
| HGNCid = 14398 | |||
| MGIid = | |||
| Symbol = SRR | |||
| AltSymbols =; ILV1; ISO1 | |||
| IUPHAR = | |||
| OMIM = 606477 | |||
| ECnumber = 4.3.1.17, 4.3.1.18, 5.1.1.18 | |||
| Homologene = 22775 | |||
| GeneAtlas_image1 = | |||
| GeneAtlas_image2 = | |||
| GeneAtlas_image3 = | |||
| Protein_domain_image = | |||
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003941 |text = L-serine ammonia-lyase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008721 |text = D-serine ammonia-lyase activity}} {{GNF_GO|id=GO:0016594 |text = glycine binding}} {{GNF_GO|id=GO:0016829 |text = lyase activity}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}} {{GNF_GO|id=GO:0018114 |text = threonine racemase activity}} {{GNF_GO|id=GO:0030165 |text = PDZ domain binding}} {{GNF_GO|id=GO:0030170 |text = pyridoxal phosphate binding}} {{GNF_GO|id=GO:0030170 |text = pyridoxal phosphate binding}} {{GNF_GO|id=GO:0030378 |text = serine racemase activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} | |||
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0043025 |text = neuronal cell body}} {{GNF_GO|id=GO:0045177 |text = apical part of cell}} | |||
| Process = {{GNF_GO|id=GO:0006563 |text = L-serine metabolic process}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0007568 |text = aging}} {{GNF_GO|id=GO:0009069 |text = serine family amino acid metabolic process}} {{GNF_GO|id=GO:0014070 |text = response to organic cyclic compound}} {{GNF_GO|id=GO:0032496 |text = response to lipopolysaccharide}} {{GNF_GO|id=GO:0042493 |text = response to drug}} {{GNF_GO|id=GO:0042866 |text = pyruvate biosynthetic process}} {{GNF_GO|id=GO:0043278 |text = response to morphine}} {{GNF_GO|id=GO:0051289 |text = protein homotetramerization}} {{GNF_GO|id=GO:0070178 |text = D-serine metabolic process}} {{GNF_GO|id=GO:0070179 |text = D-serine biosynthetic process}} | |||
| Hs_EntrezGene = 63826 | |||
| Hs_Ensembl = ENSG00000167720 | |||
| Hs_RefseqmRNA = NM_021947.1 | |||
| Hs_RefseqProtein = NP_068766.1 | |||
| Hs_GenLoc_db = hg19 | |||
| Hs_GenLoc_chr = 17 | |||
| Hs_GenLoc_start = 2207248 | |||
| Hs_GenLoc_end = 2228554 | |||
| Hs_Uniprot = Q9GZT4 | |||
| Mm_EntrezGene = 27364 | |||
| Mm_Ensembl = ENSMUSG00000001323 | |||
| Mm_RefseqmRNA = NM_001163311.1 | |||
| Mm_RefseqProtein = NP_001156783.1 | |||
| Mm_GenLoc_db = mm9 | |||
| Mm_GenLoc_chr = 11 | |||
| Mm_GenLoc_start = 74719861 | |||
| Mm_GenLoc_end = 74739450 | |||
| Mm_Uniprot = Q9QZX7 | |||
| path = PBB/63826 | |||
}} | |||
英：serine racemase 独：Serin racemase 英略称：SR | |||
L-セリンからのラセミ化反応およびD,L-セリンのデヒドラターゼ反応（α,β-脱離）を触媒する酵素である<ref><pubmed>9892700</pubmed></ref> <ref><pubmed>15536068</pubmed></ref>。ラセミ化反応ではD-セリン、デヒドラターゼ反応によりピルビン酸とアンモニアが産生される。SRは種々の生物に広く存在しており、これまでにカイコ、ラット、マウス、ヒト、シロイヌナズナなどから精製、遺伝子クローニングされている。 | L-セリンからのラセミ化反応およびD,L-セリンのデヒドラターゼ反応（α,β-脱離）を触媒する酵素である<ref><pubmed>9892700</pubmed></ref> <ref><pubmed>15536068</pubmed></ref>。ラセミ化反応ではD-セリン、デヒドラターゼ反応によりピルビン酸とアンモニアが産生される。SRは種々の生物に広く存在しており、これまでにカイコ、ラット、マウス、ヒト、シロイヌナズナなどから精製、遺伝子クローニングされている。 | ||