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MPOAには複数の細胞集積が認められるが、視床下部の「核」と異なり、必ずしも境界は鮮明ではない。中央部に位置する性的二型核(sexually dimorphic nucleus of the preoptic area, SDN-POA, (Gorski et al., 1978))はニッスル染色で比較的鮮明に描出され、ラット雄が雌より多数のニューロンを擁する (Orikasa et al., 2002)。この核はハムスター、フェレット、テンジクネズミ、ヒツジ、サル、ヒトで認められ(文献はOrikasa & Sakuma, 2010)、長年にわたりマウスではこの核が存在しないとする主張(Young, 1982など)は、calbindin 28k を標識タンパクとして用いて2010年に複数の系統で反駁・立証された(Orikasa & Sakuma, 2010)。<BR> | MPOAには複数の細胞集積が認められるが、視床下部の「核」と異なり、必ずしも境界は鮮明ではない。中央部に位置する性的二型核(sexually dimorphic nucleus of the preoptic area, SDN-POA, (Gorski et al., 1978))はニッスル染色で比較的鮮明に描出され、ラット雄が雌より多数のニューロンを擁する (Orikasa et al., 2002)。この核はハムスター、フェレット、テンジクネズミ、ヒツジ、サル、ヒトで認められ(文献はOrikasa & Sakuma, 2010)、長年にわたりマウスではこの核が存在しないとする主張(Young, 1982など)は、calbindin 28k を標識タンパクとして用いて2010年に複数の系統で反駁・立証された(Orikasa & Sakuma, 2010)。<BR> | ||
その他の細胞集積には、第３脳室に接する傍室部で吻側から終板器官、前腹側傍室核、腹内側視索前野核、正中視索前核(以下MnPO)、傍室視索前核などが同定されている。内側部では内側視索前核が中心部に大きな体積を占め、そのほかに傍分界条核、後背側視索前核、腹外側視索前核、中隔視床下部核といった細胞集積がある。マウスMPOA前額断の概要は | その他の細胞集積には、第３脳室に接する傍室部で吻側から終板器官、前腹側傍室核、腹内側視索前野核、正中視索前核(以下MnPO)、傍室視索前核などが同定されている。内側部では内側視索前核が中心部に大きな体積を占め、そのほかに傍分界条核、後背側視索前核、腹外側視索前核、中隔視床下部核といった細胞集積がある。マウスMPOA前額断の概要は[http://connectivity.brain-map.org/static/referencedata" Allen Brain Atlas (2004)]に見ることができる。<BR> | ||
<BR>==機能 == | <BR>==機能 == | ||
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