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 Bromoxyuridine (BrdU) の取り込み実験から、MPOAの主な[[ニューロン]]はラットでは胎生14-18日に第三脳室壁から発生する (Orikasa et al., 2010)。3[[脳胞]]のうち[[前脳]] (forebrain)の尾側端に由来するので、発生学的には[[終脳]] (telencephalon)に属するが、機能的観点から、[[間脳]] (diencephalon)の最吻側部である視床下部と一体とされることがある (Le Gros Clark & Meyer, 1950)。かつては[[脳原基]]の部域化に関わる多くの[[転写因子]]やシグナル分子に[[視床下部]]と共通するものがあり、たとえばDlx5、 Pax6、Nkx2.1aの発現パターンから終脳と間脳の分節境界域 prosomeric boundaryを決定することはできないと論じられた(Puelles and Rubenstein, 2003)。一方、下郡らは異なった発生段階のマウス胎仔のMPOAと視床下部のマイクロアレイ解析からマウス胎児の終脳ではFoxg1が、間脳吻側端にはGdf10が発現し境界が存在することを示した(Blackshaw et al., 2010)。MPOAは終脳のFoxg1陽性細胞に由来し、間脳由来の視床下部とは起源が異なる。また、視床下部のランドマーク遺伝子であるソニックヘッジホッグ (Shh)のノックアウトマウスでは視床下部吻側部が欠損するが、MPOAは形成される。<BR>
 Bromoxyuridine (BrdU) の取り込み実験から、MPOAの主な[[ニューロン]]はラットでは胎生14-18日に第三脳室壁から発生する (Orikasa et al., 2010)。3[[脳胞]]のうち[[前脳]] (forebrain)の尾側端に由来するので、発生学的には[[終脳]] (telencephalon)に属するが、機能的観点から、[[間脳]] (diencephalon)の最吻側部である視床下部と一体とされることがある (Le Gros Clark & Meyer, 1950)。かつては[[脳原基]]の部域化に関わる多くの[[転写因子]]やシグナル分子に[[視床下部]]と共通するものがあり、たとえばDlx5、 Pax6、Nkx2.1aの発現パターンから終脳と間脳の分節境界域 prosomeric boundaryを決定することはできないと論じられた(Puelles and Rubenstein, 2003)。一方、下郡らは異なった発生段階のマウス胎仔のMPOAと視床下部のマイクロアレイ解析からマウス胎児の終脳ではFoxg1が、間脳吻側端にはGdf10が発現し境界が存在することを示した(Blackshaw et al., 2010)。MPOAは終脳のFoxg1陽性細胞に由来し、間脳由来の視床下部とは起源が異なる。また、視床下部のランドマーク遺伝子であるソニックヘッジホッグ (Shh)のノックアウトマウスでは視床下部吻側部が欠損するが、MPOAは形成される。<BR>
 第三脳室壁から発生するニューロンに加え、[[wikipedia:ja:齧歯類|齧歯類]]では[[性腺刺激ホルモン放出ホルモン]](gonadotropin releasing hormone, GnRH)産生ニューロンが嗅上皮の原基である内側嗅板medial olfactory placodeに発生し視索前野に移動し定着する(Schwanzel-Fukuda & Pfaff, 1989)。Xp22.3上の[[KAL-1]]遺伝子の異常により生じるヒトのKallmann症候群は[[無嗅覚症]]を伴う伴性低ゴナドトロピン性[[性腺機能不全]]で、GnRHニューロンは前頭の篩骨を透過できずこの移動が起こらない。ただし、正常なrhesusやヒトのではGnRHニューロンはさらに尾側に移動を続け、視床下部内側底部から隆起漏斗部に定着する。この移動・定着の障害が視床下部性性腺機能低下症の一つであるKallman症候の病因である(Schwanzel-Fukuda et al., 1989) [[内側視索前野|下記病態参照]]。<BR>
 第三脳室壁から発生するニューロンに加え、[[wikipedia:ja:齧歯類|齧歯類]]では[[性腺刺激ホルモン放出ホルモン]](gonadotropin releasing hormone, GnRH)産生ニューロンが嗅上皮の原基である内側嗅板medial olfactory placodeに発生し視索前野に移動し定着する(Schwanzel-Fukuda & Pfaff, 1989)。Xp22.3上の[[KAL-1]]遺伝子の異常により生じるヒトのKallmann症候群は[[無嗅覚症]]を伴う伴性低ゴナドトロピン性[[性腺機能不全]]で、GnRHニューロンは前頭の篩骨を透過できずこの移動が起こらない。ただし、正常なrhesusやヒトのではGnRHニューロンはさらに尾側に移動を続け、視床下部内側底部から隆起漏斗部に定着する。この移動・定着の障害が視床下部性性腺機能低下症の一つであるKallman症候の病因である(Schwanzel-Fukuda et al., 1989) (下記病態参照)。<BR>


<BR>== 構造 ==<BR>
<BR>== 構造 ==<BR>
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AGMO, A. 1997. Male rat sexual behavior. Brain Res Brain Res Protoc, 1, 203-9.<BR>
AGMO, A. 1997. Male rat sexual behavior. Brain Res Brain Res Protoc, 1, 203-9.<BR>
BLACKSHAW, S., SCHOLPP, S., PLACZEK, M., INGRAHAM, H., SIMERLY, R. & SHIMOGORI, T. 2010. Molecular pathways controlling development of thalamus and hypothalamus: from neural specification to circuit formation. J Neurosci, 30, 14925-30.<BR>
BLACKSHAW, S., SCHOLPP, S., PLACZEK, M., INGRAHAM, H., SIMERLY, R. & SHIMOGORI, T. 2010. Molecular pathways controlling development of thalamus and hypothalamus: from neural specification to circuit formation. J Neurosci, 30, 14925-30.<BR>
BRUCH, H. 1939. The Fröhlich syndrome: Report of the original case. Am J Dis Child, 1939; 58(6):128, 58, 1282-1289<BR>
BRUCH, H. 1939. The Fröhlich syndrome: Report of the original case. Am J Dis Child, 1939; 58(6): 1282-1289<BR>
BRUDZYNSKI, S. M. & MOGENSON, G. J. 1986. Decrease of locomotor activity by injections of carbachol into the anterior hypothalamic/preoptic area of the rat. Brain Res, 376, 38-46.<BR>
BRUDZYNSKI, S. M. & MOGENSON, G. J. 1986. Decrease of locomotor activity by injections of carbachol into the anterior hypothalamic/preoptic area of the rat. Brain Res, 376, 38-46.<BR>
CHUNG, S., WEBER, F., ZHONG, P., TAN, C. L., NGUYEN, T. N., BEIER, K. T., HORMANN, N., CHANG, W. C., ZHANG, Z., DO, J. P., YAO, S., KRASHES, M. J., TASIC, B., CETIN, A., ZENG, H., KNIGHT, Z. A., LUO, L. & DAN, Y. 2017. Identification of preoptic sleep neurons using retrograde labelling and gene profiling. Nature, 545, 477-481.<BR>
CHUNG, S., WEBER, F., ZHONG, P., TAN, C. L., NGUYEN, T. N., BEIER, K. T., HORMANN, N., CHANG, W. C., ZHANG, Z., DO, J. P., YAO, S., KRASHES, M. J., TASIC, B., CETIN, A., ZENG, H., KNIGHT, Z. A., LUO, L. & DAN, Y. 2017. Identification of preoptic sleep neurons using retrograde labelling and gene profiling. Nature, 545, 477-481.<BR>
83行目: 83行目:
HASEGAWA, T. & SAKUMA, Y. 1993. Developmental effect of testosterone on estrogen sensitivity of the rat preoptic neurons with axons to the ventral tegmental area. Brain Res, 611, 1-6.<BR>
HASEGAWA, T. & SAKUMA, Y. 1993. Developmental effect of testosterone on estrogen sensitivity of the rat preoptic neurons with axons to the ventral tegmental area. Brain Res, 611, 1-6.<BR>
HASEGAWA, T., TAKEO, T., AKITSU, H., HOSHINA, Y. & SAKUMA, Y. 1991. Interruption of the lordosis reflex of female rats by ventral midbrain stimulation. Physiol Behav, 50, 1033-8.<BR>
HASEGAWA, T., TAKEO, T., AKITSU, H., HOSHINA, Y. & SAKUMA, Y. 1991. Interruption of the lordosis reflex of female rats by ventral midbrain stimulation. Physiol Behav, 50, 1033-8.<BR>
HERBISON, A. E. 1997. ESTROGEN REGULATION OF GABA TRANSMISSION IN RAT PREOPTIC AREA. Brain Res Bull, 44, 321-326.<BR>
HERBISON, A. E. 1997. Estrogen regulation of GABA transmission in rat preoptic area. Brain Res Bull, 44, 321-326.<BR>
HERBISON, A. E., HEAVENS, R. P., DYE, S. & DYER, R. G. 1991. Acute action of oestrogen on medial preoptic gamma-aminobutyric acid neurons: correlation with oestrogen negative feedback on luteinizing hormone secretion. J Neuroendocrinol, 3, 101-106.<BR>
HERBISON, A. E., HEAVENS, R. P., DYE, S. & DYER, R. G. 1991. Acute action of oestrogen on medial preoptic gamma-aminobutyric acid neurons: correlation with oestrogen negative feedback on luteinizing hormone secretion. J Neuroendocrinol, 3, 101-106.<BR>
HOSHINA, Y., TAKEO, T., NAKANO, K., SATO, T. & SAKUMA, Y. 1994. Axon-sparing lesion of the preoptic area enhances receptivity and diminishes proceptivity among components of female rat sexual behavior. Behav Brain Res, 61, 197-204.<BR>
HOSHINA, Y., TAKEO, T., NAKANO, K., SATO, T. & SAKUMA, Y. 1994. Axon-sparing lesion of the preoptic area enhances receptivity and diminishes proceptivity among components of female rat sexual behavior. Behav Brain Res, 61, 197-204.<BR>
89行目: 89行目:
LARSSON, K. & HEIMER, L. 1964. Mating behaviour of male rats after lesions in the preoptic area. Nature, 202, 413-4.<BR>
LARSSON, K. & HEIMER, L. 1964. Mating behaviour of male rats after lesions in the preoptic area. Nature, 202, 413-4.<BR>
LE GROS CLARK, W. E. & MEYER, R., M. 1950. Anatomical relationships between the cerebral cortex and the hypothalamus. Brit Med Bull, 6, 341-344.<BR>
LE GROS CLARK, W. E. & MEYER, R., M. 1950. Anatomical relationships between the cerebral cortex and the hypothalamus. Brit Med Bull, 6, 341-344.<BR>
MORENO, N. & GONZÁÁLEZ, A. 2011. The non-evaginated secondary prosencephalon of vertebrates. Front Neuroanat. [https://doi.org/10.3389/fnana.2011.00012]<BR>
MORENO, N. & GONZÁÁLEZ, A. 2011. The non-evaginated secondary prosencephalon of vertebrates. [https://doi.org/10.3389/fnana.2011.00012 Front Neuroanat.]<BR>
MORI, S., MATSUYAMA, K., KOHYAMA, J., KOBAYASHI, Y. & TAKAKUSAKI, K. 1992. Neuronal constituents of postural and locomotor control systems and their interactions in cats. Brain Dev., 14 Suppl., S109-S120.<BR>
MORI, S., MATSUYAMA, K., KOHYAMA, J., KOBAYASHI, Y. & TAKAKUSAKI, K. 1992. Neuronal constituents of postural and locomotor control systems and their interactions in cats. Brain Dev., 14 Suppl., S109-S120.<BR>
NAKAYAMA, T., SUZUKI, M. & ISHIZUKA, N. 1975. Action of progesterone on preoptic thermosensitive neurones. Nature, 258, 80.<BR>
NAKAYAMA, T., SUZUKI, M. & ISHIZUKA, N. 1975. Action of progesterone on preoptic thermosensitive neurones. Nature, 258, 80.<BR>
97行目: 97行目:
緒方勤 & 田中敏章. 2006. 低ゴナドトロピン性性腺機能不全:分子遺伝学的および臨床的側面. 日本生殖内分泌学会雑誌, 11, 11-16.<BR>
緒方勤 & 田中敏章. 2006. 低ゴナドトロピン性性腺機能不全:分子遺伝学的および臨床的側面. 日本生殖内分泌学会雑誌, 11, 11-16.<BR>
OGAWA, S., CHOLERIS, E. & PFAFF, D. 2004. Genetic influences on aggressive behaviors and arousability in animals. Ann New York Acad Sci, 1036, 257-266.<BR>
OGAWA, S., CHOLERIS, E. & PFAFF, D. 2004. Genetic influences on aggressive behaviors and arousability in animals. Ann New York Acad Sci, 1036, 257-266.<BR>
ORIKASA, C., KONDO, Y., HAYASHI, S., MCEWEN, B. S. & SAKUMA, Y. 2002. Sexually dimorphic expression of estrogen receptor b in the anteroventral periventricular nucleus of the rat preoptic area: Implication in luteinizing hormone surge. Proc Natl Acad Sci U S A, 99, 3306-11.<BR>
ORIKASA, C., KONDO, Y., HAYASHI, S., MCEWEN, B. S. & SAKUMA, Y. 2002. Sexually dimorphic expression of estrogen receptor beta in the anteroventral periventricular nucleus of the rat preoptic area: Implication in luteinizing hormone surge. Proc Natl Acad Sci U S A, 99, 3306-11.<BR>
ORIKASA, C., KONDO, Y., USUI, S. & SAKUMA, Y. 2010. Similar numbers of neurons are generated in the male and female rat preoptic area in utero. Neurosci Res, 68, 9-14.<BR>
ORIKASA, C., KONDO, Y., USUI, S. & SAKUMA, Y. 2010. Similar numbers of neurons are generated in the male and female rat preoptic area in utero. Neurosci Res, 68, 9-14.<BR>
ORIKASA, C. & SAKUMA, Y. 2010. Estrogen configures sexual dimorphism in the preoptic area of C57BL/6J and ddN strains of mice. J Comp Neurol, 518, 3618-29.<BR>
ORIKASA, C. & SAKUMA, Y. 2010. Estrogen configures sexual dimorphism in the preoptic area of C57BL/6J and ddN strains of mice. J Comp Neurol, 518, 3618-29.<BR>
PARHAR, I. S. 2004. Laser-captured single digoxigenin-labeled neurons of gonadotropin-releasing hormone types reveal a novel G protein-coupled receptor (Gpr54) during maturation in cichlid fish. Endocrinology, 145, 3613-3618.<BR>
PARHAR, I. S. 2004. Laser-captured single digoxigenin-labeled neurons of gonadotropin-releasing hormone types reveal a novel G protein-coupled receptor (GPR54) during maturation in cichlid fish. Endocrinology, 145, 3613-3618.<BR>
PARHAR, I. S., OGAWA, S. & SAKUMA, Y. 2004. Laser-captured single digoxigenin-labeled neurons of gonadotropin-releasing hormone types reveal a novel G protein-coupled receptor (GPR54) during maturation in cichlid fish. Endocrinology, 145, 3613-3618.<BR>
PARHAR, I. S., OGAWA, S. & SAKUMA, Y. 2004. Laser-captured single digoxigenin-labeled neurons of gonadotropin-releasing hormone types reveal a novel G protein-coupled receptor (GPR54) during maturation in cichlid fish. Endocrinology, 145, 3613-3618.<BR>
PUELLES, L. & RUBENSTEIN, J. L. R. 2003. Forebrain gene expression domains and the evolving prosomeric model. Trends Neurosci, 26, 469-476.<BR>
PUELLES, L. & RUBENSTEIN, J. L. R. 2003. Forebrain gene expression domains and the evolving prosomeric model. Trends Neurosci, 26, 469-476.<BR>
122行目: 122行目:
TAKEO, T. & SAKUMA, Y. 1995. Diametrically opposite effects of estrogen on the excitability of female rat medial and lateral preoptic neurons with axons to the midbrain locomotor region. Neurosci Res, 22, 73-80.<BR>
TAKEO, T. & SAKUMA, Y. 1995. Diametrically opposite effects of estrogen on the excitability of female rat medial and lateral preoptic neurons with axons to the midbrain locomotor region. Neurosci Res, 22, 73-80.<BR>
WAKABAYASHI, Y., NAKADA, T., MURATA, K., OHKURA, S., MOGI, K., NAVARRO, V. M., CLIFTON, D. K., MORI, Y., TSUKAMURA, H., MAEDA, K., STEINER, R. A. & OKAMURA, H. 2010. Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat. J Neurosci, 30, 3124-32.<BR>
WAKABAYASHI, Y., NAKADA, T., MURATA, K., OHKURA, S., MOGI, K., NAVARRO, V. M., CLIFTON, D. K., MORI, Y., TSUKAMURA, H., MAEDA, K., STEINER, R. A. & OKAMURA, H. 2010. Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat. J Neurosci, 30, 3124-32.<BR>
WATANABE, M., SAKUMA, Y. & KATO, M. 2009. GABAA receptors mediate excitation in adult rat GnRH neurons. Biol Reprod, 81, 327-32.<BR>
WATANABE, M., SAKUMA, Y. & KATO, M. 2009. GABA<sub>A</sub> receptors mediate excitation in adult rat GnRH neurons. Biol Reprod, 81, 327-32.<BR>
WHITNEY, J. F. 1986. Effect of medial preoptic lesions on sexual behavior of female rats is determined by test situation. Behavioral Neuroscience, 100, 230-235.<BR>
WHITNEY, J. F. 1986. Effect of medial preoptic lesions on sexual behavior of female rats is determined by test situation. Behavioral Neuroscience, 100, 230-235.<BR>
WU, Z., AUTRY, A. E., BERGAN, J. F., WATABE-UCHIDA, M. & DULAC, C. G. 2014. Galanin neurons in the medial preoptic area govern parental behaviour. Nature, 509, 325-30.<BR>
WU, Z., AUTRY, A. E., BERGAN, J. F., WATABE-UCHIDA, M. & DULAC, C. G. 2014. Galanin neurons in the medial preoptic area govern parental behaviour. Nature, 509, 325-30.<BR>
YOSHIHARA, C., TOKITA, K., MARUYAMA, T., KANEKO, M., TSUNEOKA, Y., FUKUMITSU, K., MIYAZAWA, E., SHINOZUKA, K., HUANG, A. J., NISHIMORI, K., MCHUGH, T. J., TANAKA, M., ITOHARA, S., TOUHARA, K., MIYAMICHI, K. & KURODA, K. O. 2021. Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care. Cell Rep, 35, 109204.<BR>
YOSHIHARA, C., TOKITA, K., MARUYAMA, T., KANEKO, M., TSUNEOKA, Y., FUKUMITSU, K., MIYAZAWA, E., SHINOZUKA, K., HUANG, A. J., NISHIMORI, K., MCHUGH, T. J., TANAKA, M., ITOHARA, S., TOUHARA, K., MIYAMICHI, K. & KURODA, K. O. 2021. Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care. Cell Rep, 35, 109204.<BR>
YOUNG, J. K. 1982. A comparison of hypothalami of rats and mice: lack of gross sexual dimorphism in the mouse. Brain Res, 239, 233-239.<BR>
YOUNG, J. K. 1982. A comparison of hypothalami of rats and mice: lack of gross sexual dimorphism in the mouse. Brain Res, 239, 233-239.<BR>
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