「BHLH因子」の版間の差分

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[[Image:Table1v3.jpg|500px]]       
[[Image:Table1v3.jpg|500px]]       


=== 発現パターンによる分類  ===
=== 発現パターンによる分類<br> ===


[[Image:Table2v3.jpg|500px]]<br>
'''''&nbsp; Class I : &nbsp;&nbsp;'''''多くの組織に普遍的に存在 &nbsp; &nbsp; Tcf3 (E12/E47), Tcf4 (E2-2) etc.


組織特異的に発現するbHLH因子 (Class II) の多くはClass IのbHLH因子とへテロダイマーを形成してDNAに結合し転写を活性化する。  
&nbsp;&nbsp;'''''Class II :&nbsp;''''' 組織特異的に発現 &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; MyoD, Neurog (Ngn), Hes etc.
 
 組織特異的に発現するbHLH因子 (Class II) の多くはClass IのbHLH因子とへテロダイマーを形成してDNAに結合し転写を活性化する。  


=== 機能的分類(脳神経系における主要機能別分類)  ===
=== 機能的分類(脳神経系における主要機能別分類)  ===
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'''''&nbsp; Promotion of neuronal differentiation''''' <br>&nbsp; &nbsp; Ascl1 (Mash1), Atoh1 (Math1), Ebf1, Ebf2, Ebf3, Ebf4, Hand1, Hand2, Hes6, Neurod1 (Neurod/Beta2), Neurod2 (Ndrf), Neurod4 (Math3),  
'''''&nbsp; Promotion of neuronal differentiation''''' <br>&nbsp; &nbsp; Ascl1 (Mash1), Atoh1 (Math1), Ebf1, Ebf2, Ebf3, Ebf4, Hand1, Hand2, Hes6, Neurod1 (Neurod/Beta2), Neurod2 (Ndrf), Neurod4 (Math3),  


&nbsp; &nbsp; Neurod6 (Math2), Neurog1 (Ngn1), Neurog2 (Ngn2), Ptf1a, Sim1
&nbsp; &nbsp; Neurod6 (Math2), Neurog1 (Ngn1), Neurog2 (Ngn2), Ptf1a, Sim1  


'''''&nbsp; Inhibition of neuronal differentiation''''' <br>&nbsp; &nbsp; Hes1, Hes3, Hes5, Hey1, Hey2, HeyL (Hey3)
'''''&nbsp; Inhibition of neuronal differentiation''''' <br>&nbsp; &nbsp; Hes1, Hes3, Hes5, Hey1, Hey2, HeyL (Hey3)  


'''''&nbsp; Glial differentiation'''''<br>&nbsp; &nbsp; Olig1, Olig2, Olig3, Tal1 (Scl)
'''''&nbsp; Glial differentiation'''''<br>&nbsp; &nbsp; Olig1, Olig2, Olig3, Tal1 (Scl)  


'''''&nbsp; Cerebellar development'''''<br>&nbsp; &nbsp; Atoh1 (Math1), Nhlh1 (Nscl1), Nhlh2 (Nscl2), Ptf1a
'''''&nbsp; Cerebellar development'''''<br>&nbsp; &nbsp; Atoh1 (Math1), Nhlh1 (Nscl1), Nhlh2 (Nscl2), Ptf1a  


'''''&nbsp; Autonomic neurogenesis'''''<br>&nbsp; &nbsp; Ascl1 (Mash1), Hand1, Hand2
'''''&nbsp; Autonomic neurogenesis'''''<br>&nbsp; &nbsp; Ascl1 (Mash1), Hand1, Hand2  


'''''&nbsp; Circadian rhythm'''''<br>&nbsp; &nbsp; Ahr, Ahrr, Arntl (Bmal1), Clock, Bhlhe40 (Dec1), Bhlhe41 (Dec2), Npas, Per, Sim
'''''&nbsp; Circadian rhythm'''''<br>&nbsp; &nbsp; Ahr, Ahrr, Arntl (Bmal1), Clock, Bhlhe40 (Dec1), Bhlhe41 (Dec2), Npas, Per, Sim  


'''''&nbsp; Cell cycle'''''<br>&nbsp; &nbsp; Myc (c-Myc), Mycn (N-Myc)
'''''&nbsp; Cell cycle'''''<br>&nbsp; &nbsp; Myc (c-Myc), Mycn (N-Myc)  


'''''&nbsp; Cofactor'''''<br>&nbsp; &nbsp; Tcf3 (E12/E47), Tcf4 (E2-2)<br>  
'''''&nbsp; Cofactor'''''<br>&nbsp; &nbsp; Tcf3 (E12/E47), Tcf4 (E2-2)<br>  


*The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the bHLH family (http://www.genenames.org/genefamily/bhlh.php)
 ・The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the bHLH family  
 
  (http://www.genenames.org/genefamily/bhlh.php)  


== 機能  ==
== 機能  ==
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