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Toshiyukiotsuka (トーク | 投稿記録) 細編集の要約なし |
Toshiyukiotsuka (トーク | 投稿記録) 細編集の要約なし |
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[[Image:Table1v3.jpg|500px]] | [[Image:Table1v3.jpg|500px]] | ||
=== 発現パターンによる分類 === | === 発現パターンによる分類<br> === | ||
''''' Class I : '''''多くの組織に普遍的に存在 Tcf3 (E12/E47), Tcf4 (E2-2) etc. | |||
'''''Class II : ''''' 組織特異的に発現 MyoD, Neurog (Ngn), Hes etc. | |||
組織特異的に発現するbHLH因子 (Class II) の多くはClass IのbHLH因子とへテロダイマーを形成してDNAに結合し転写を活性化する。 | |||
=== 機能的分類(脳神経系における主要機能別分類) === | === 機能的分類(脳神経系における主要機能別分類) === | ||
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''''' Promotion of neuronal differentiation''''' <br> Ascl1 (Mash1), Atoh1 (Math1), Ebf1, Ebf2, Ebf3, Ebf4, Hand1, Hand2, Hes6, Neurod1 (Neurod/Beta2), Neurod2 (Ndrf), Neurod4 (Math3), | ''''' Promotion of neuronal differentiation''''' <br> Ascl1 (Mash1), Atoh1 (Math1), Ebf1, Ebf2, Ebf3, Ebf4, Hand1, Hand2, Hes6, Neurod1 (Neurod/Beta2), Neurod2 (Ndrf), Neurod4 (Math3), | ||
Neurod6 (Math2), Neurog1 (Ngn1), Neurog2 (Ngn2), Ptf1a, Sim1 | Neurod6 (Math2), Neurog1 (Ngn1), Neurog2 (Ngn2), Ptf1a, Sim1 | ||
''''' Inhibition of neuronal differentiation''''' <br> Hes1, Hes3, Hes5, Hey1, Hey2, HeyL (Hey3) | ''''' Inhibition of neuronal differentiation''''' <br> Hes1, Hes3, Hes5, Hey1, Hey2, HeyL (Hey3) | ||
''''' Glial differentiation'''''<br> Olig1, Olig2, Olig3, Tal1 (Scl) | ''''' Glial differentiation'''''<br> Olig1, Olig2, Olig3, Tal1 (Scl) | ||
''''' Cerebellar development'''''<br> Atoh1 (Math1), Nhlh1 (Nscl1), Nhlh2 (Nscl2), Ptf1a | ''''' Cerebellar development'''''<br> Atoh1 (Math1), Nhlh1 (Nscl1), Nhlh2 (Nscl2), Ptf1a | ||
''''' Autonomic neurogenesis'''''<br> Ascl1 (Mash1), Hand1, Hand2 | ''''' Autonomic neurogenesis'''''<br> Ascl1 (Mash1), Hand1, Hand2 | ||
''''' Circadian rhythm'''''<br> Ahr, Ahrr, Arntl (Bmal1), Clock, Bhlhe40 (Dec1), Bhlhe41 (Dec2), Npas, Per, Sim | ''''' Circadian rhythm'''''<br> Ahr, Ahrr, Arntl (Bmal1), Clock, Bhlhe40 (Dec1), Bhlhe41 (Dec2), Npas, Per, Sim | ||
''''' Cell cycle'''''<br> Myc (c-Myc), Mycn (N-Myc) | ''''' Cell cycle'''''<br> Myc (c-Myc), Mycn (N-Myc) | ||
''''' Cofactor'''''<br> Tcf3 (E12/E47), Tcf4 (E2-2)<br> | ''''' Cofactor'''''<br> Tcf3 (E12/E47), Tcf4 (E2-2)<br> | ||
・The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the bHLH family | |||
(http://www.genenames.org/genefamily/bhlh.php) | |||
== 機能 == | == 機能 == |
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