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…te book| vauthors = Quirk Jr JG, Wendel Jr GD | chapter = Biologic effects of natural and synthetic estrogens | veditors = Buchsbaum HJ |title=The Menopa …47" /><ref name="FishmanMartucci1980" /> As such, estrone is a [[prodrug]] of estradiol.<ref name="pmid16112947" />

…ral administration|by mouth]], DES was available for use by other [[routes of administration|routes]] as well, for instance, [[vaginal administration|vag …name="Kuhl2005"/> These differences result in DES having an increased risk of [[blood clot]]s, [[cardiovascular disease|cardiovascular issues]], and cert