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…e''', or '''estrone-3-<small>D</small>-glucuronide''', is a [[conjugation (biochemistry)|conjugated]] [[metabolite]] of [[estrone]].<ref name="HMDB">{{Cite web|url …=CRC Press|isbn=978-0-203-48612-2|pages=364–}}</ref> A single administered dose of estradiol is [[absorption (pharmacokinetics)|absorbed]] 15% as [[estrone …

…f moxestrol in animals--rat, dog and monkey | journal = Journal of Steroid Biochemistry | volume = 19 | issue = 2 | pages = 1223–1234 | date = August 1983 | pmid… …th in the treatment of menopausal, postmenopausal, and menstrual symptoms. Dose have ranged from 50 to 100 μg weekly for long-term therapy to 25 to 250 μg …

…rhoeven C, Dutman AE, Thijssen J |date=January 2017 |title=The use of high-dose estrogens for the treatment of breast cancer |journal=Maturitas |volume=95 Nafoxidine is a long-acting [[estrogen receptor]] [[ligand (biochemistry)|ligand]], with a [[nuclear retention]] in the range of 24 to 48&nbsp;hours …

==Biochemistry== …ex hormones]].<ref>{{cite book| vauthors = Devlin TM | title = Textbook of Biochemistry: with Clinical Correlations | year = 2010 | publisher = John Wiley & Sons… …

…The total [[endometrium|endometrial]] [[cell proliferation|proliferation]] dose per cycle of different forms of hexestrol are 70 to 100&nbsp;mg for [[oral …echanism of action of the female sex hormones | journal = Annual Review of Biochemistry | volume = 41 | pages = 203–230 | date = 1972 | pmid = 4563437 | doi = 10.1 …

…ingh Bennink HJ |date=2008 |title=First human exposure to exogenous single-dose oral estetrol in early postmenopausal women |journal=Climacteric |volume=11 | metabolism = Minimal, [[conjugation (biochemistry)|conjugation]] ([[glucuronidation]], [[sulfation]])<ref name="pmid18464023" …

| metabolism = [[Liver]], [[intestine]]s ([[conjugation (biochemistry)|conjugation]] ([[glucuronidation]], [[sulfation]]), [[oxidation]], [[hydro …9 }}</ref><ref name="UniversityofCalifornia1986">{{cite book|title=Applied Biochemistry of Clinical Disorders|edition=2nd |url=https://books.google.com/books?id=as …

…ndes VT, Kater CE | title = One-year clinical evaluation of single morning dose prednisolone therapy for 21-hydroxylase deficiency | journal = Arquivos Bra …bsp}}mg/m² per day, which corresponds to an oral hydrocortisone dose of approximately 15 to 20{{nbsp}}mg/day (for a 70-kg person).<ref name="Arv …

| metabolism = [[Hydroxylation]], [[conjugation (biochemistry)|conjugation]] ([[glucuronidation]], [[sulfation]])<ref name="Dörwald2013" …;ng/mL (28,000&nbsp;pg/mL) at [[Cmin (pharmacology)|trough]] with a single dose and 28.0&nbsp;ng/mL (28,000&nbsp;pg/mL) at peak and 12.2&nbsp;ng/mL (12,200 …

…e estrogen]] to treat [[prostate cancer]] in men as well as a form of high-dose estrogen to treat [[breast cancer]] in women.<ref name="ThomasKeenan1986a"> …asetto2012">{{cite book | vauthors = Deghenghi R | chapter = Chemistry and biochemistry of natural estrogens | veditors = Paoletti R, Pasetto N, Ambrus JL |title=T …

…0.1210/jc.2006-0316 | doi-access = free }}</ref> Another study delivered a dose of 50&nbsp;mg of prasterone for 10&nbsp;months with no serious adverse even …ion)|Testosterone]] levels following a single [[oral administration|oral]] dose of 300&nbsp;mg [[crystalline]] (non-micronized) or [[micronization|microniz …

…615}}</ref><ref>{{cite journal |last1=Dang |first1=Z. C. |year=2009 |title=Dose-dependent effects of soy phyto-oestrogen genistein on adipocytes: Mechanism …title=Bioflavonoids as Poisons of Human Topoisomerase IIα and IIβ |journal=Biochemistry |volume=46 |issue=20 |pages=6097–108 |pmid=17458941 |doi=10.1021/bi7000664 …

…d = 8520623 }}</ref> The medication is available in both low-dose and high-dose formulations and both alone and in combination with an [[estrogen (medicati High-dose (10&nbsp;mg/day) norethisterone has been associated with [[hepatic veno-occ …

…="Elger1972">{{Cite book | vauthors = Elger W |title=Reviews of Physiology Biochemistry and Experimental Pharmacology, Volume 67 |year=1972 |isbn=3-540-05959-8 |se …as approximately twice as potent by weight as mestranol and hence that the dose could be halved, which it was thought might result in a lower incidence of …

…| pmc = 2439524 | doi = 10.1038/bjp.2008.165 }}</ref> It is a [[substrate (biochemistry)|substrate]] for [[5α-reductase]] like testosterone, and so is potentiated …estosterone is [[excretion|excreted]] 90% in the [[urine]] as [[conjugate (biochemistry)|conjugate]]s and other [[metabolite]]s, and 6% in [[feces]].<ref name="Woo …

{{Main|Estradiol (medication)#Medical uses|High-dose estrogen}} …/><ref name="pmid13638626" /> In addition, it is used as a form of [[high-dose estrogen]] therapy in the [[palliation|palliative]] treatment of [[prostate …

…RS, Dudley RE, Page ST, Wang C, Salameh WA | title = Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels | journal… Androstanolone was used at a dose of 25&nbsp;mg sublingually two to three times per day in androgen replaceme …

…ination of flare reaction by pretreatment with cyproterone acetate and low-dose diethylstilbestrol |journal= Cancer |volume= 72 |issue= 5 |pages= 1685–91… …s=6 |title=A randomized phase 2 trial of low dose (6 mg daily) versus high dose (30 mg daily) estradiol for patients with estrogen receptor positive aromat …

…xifen)<ref name="Sanchez-SpitmanSwen2019" /><br />• Others, [[conjugation (biochemistry)|conjugates]]<ref name="Sanchez-SpitmanSwen2019" /><ref name="pmid21451508" …n reported in humans.<ref name="Nolvadex-Label" /> In [[dose-ranging study|dose-ranging studies]], tamoxifen was administered at very high doses in women… …

…Kroboth PD, Cameron WJ, Dittert LW, Chungi V, Manberg PJ | title = Single-dose pharmacokinetics of clomiphene citrate in normal volunteers | journal = Fer Clomifene is a long-acting ER [[ligand (biochemistry)|ligand]], with a [[nuclear retention]] of greater than 48&nbsp;hours.<ref …