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….1.1| doi-access = free }}</ref> [[CYP1A2]] and [[CYP3A4]] are the major [[enzyme]]s catalyzing the 2-hydroxylation of estradiol.<ref name="pmid9472688" />… …ylated]] and 2-[[methoxy]]lated derivatives showed only weak or negligible inhibition.<ref name="pmid447670" /> Moreover, 2-hydroxyestradiol has been found to bi …

…name="KingGhosh2006">{{cite journal | first1=Roberta | last1=King | title=Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti …9952 | doi-access = free | pmid = 9039952 | s2cid = 22112485 }}</ref> an [[enzyme]] that contributes to the inactivation of estradiol via conversion of it in …

…ology)|tissue]]s via 2-[[hydroxylation]] mediated by [[cytochrome P450]] [[enzyme]]s, mainly the [[CYP3A]] and [[CYP1A]] subfamilies.<ref name="OettelSchilli …e="pmid3013588">{{cite journal | vauthors = Okatani Y, Fishman J | title = Inhibition of the preovulatory prolactin surge in the rat by catechol estrogens: funct …

…y stimulated CYP3A4 (by 83%) and ethinylestradiol moderately inhibited the enzyme (by 45%).<ref name="pmid18464023" /><ref name="pmid18464025" /> These findi …s of [[hot flash]] relief, [[antigonadotropic]] effects, and [[ovulation]] inhibition).<ref name="pmid18464023" /><ref name="pmid26056044" /> It has comparable… …

…hese enzymes are involved in the biosynthesis of [[steroid]] hormones, and inhibition of these enzymes results in the interference with hormone [[metabolism]].<r …

…]]; TIP60: [[K(lysine) acetyltransferase5]]; UBC9: [[ubiquitin-conjugating enzyme E2I]] …により大きく影響を受ける。HDACは転写因子[[Yin Yang1]]（[[YY1]]）と強調してオリゴデンドロサイトの発現を抑制する転写調節因子[[inhibition of differentiation 4]]（[[Id4]]）および[[T-cell factor]]（[[TCF]]）を抑制することでオリゴデンドロ …

…= 10.3389/fphar.2017.00103 | doi-access = free }}</ref> For this reason, [[enzyme inhibitor]]s of steroid sulfatase and 17β-hydroxysteroid dehydrogenase and …Potter BV | title = Steroid sulfatase: molecular biology, regulation, and inhibition | journal = Endocr. Rev. | volume = 26 | issue = 2 | pages = 171–202 | date …

* inhibition of several [[tyrosine kinase]]s * inhibition of [[topoisomerase]] …

…ay in which norethisterone may be acting to reduce endometrial pain is via inhibition of [[ovulation]]. Endometriosis pain and discomfort is worse during ovulati …| doi = 10.1210/jcem.87.2.8218 | doi-access = free }}</ref> These [[liver enzyme]]s included [[lactate dehydrogenase]] and [[glutamate pyruvate transaminase …

…of recurrence, due to their lack of competitive metabolism for the CYP2D6 enzyme.<ref>{{Cite news |last=Staff Reports |date=Summer 2009 |title=ASCO Updates: …ism Predicts Tamoxifen Response: PAX2 gene implicated in tamoxifen-induced inhibition of ERBB2/HER2-mediated tumor growth |url=http://www.modernmedicine.com/mode …

…ne interaction with the estrogen receptor. II. Estriol and estrone-induced inhibition of the cooperative binding of [3H]estradiol to the estrogen receptor | jour …on of [[luteinizing hormone]] and [[follicle-stimulating hormone]] levels, inhibition of [[bone resorption]], and relief of [[menopausal symptoms]] such as [[hot …

Resveratrol is produced in plants via the enzyme [[resveratrol synthase]] ([[stilbene synthase]]).<ref name=":0">{{cite jour …ion of mulberroside A from Morus alba results in enhancement of tyrosinase inhibition | journal = Journal of Industrial Microbiology & Biotechnology | volume =… …

…2014">{{cite journal | vauthors = Girgert R, Emons G, Gründker C | title = Inhibition of GPR30 by estriol prevents growth stimulation of triple-negative breast… …(HDL) [[cholesterol]].<ref name="pmid16112947" /> A study of [[ovulation]] inhibition by estrogens in women found that prevention of ovulation occurred with 5&nb …

…erone [[enzyme inducer|induce]]s several [[hepatic]] [[cytochrome P450]] [[enzyme]]s,<ref name="Meanwell2014">{{cite book|vauthors=Meanwell NA|title=Tactics …s. The testes then produce testosterone, which is converted to DHT via the enzyme [[5α-Reductase|5α-reductase]]. DHT is a potent androgen that is responsible …

…lisher=Saunders|isbn=978-0-7216-3575-0|quote=Estrogen excess in men causes inhibition of gonadotropin secretion and secondary hypogonadism. Estrogen excess may… …e journal | vauthors = Schubert W, Cullberg G, Edgar B, Hedner T | title = Inhibition of 17 beta-estradiol metabolism by grapefruit juice in ovariectomized women …

…educed Pituitary Luteinizing Hormone Secretion and Decreased Steroidogenic Enzyme Gene Expression in Rat Leydig Cells |journal=Endocrinology |date=1 February …