テンプレート:PBB/2932のソースを表示

{{GNF_Protein_box
 | Name = Glycogen synthase kinase 3 beta
 | image = Protein_GSK3B_PDB_1gng.png
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gng.
 | PDB = {{PDB2|1GNG}}, {{PDB2|1H8F}}, {{PDB2|1I09}}, {{PDB2|1J1B}}, {{PDB2|1J1C}}, {{PDB2|1O9U}}, {{PDB2|1PYX}}, {{PDB2|1Q3D}}, {{PDB2|1Q3W}}, {{PDB2|1Q41}}, {{PDB2|1Q4L}}, {{PDB2|1Q5K}}, {{PDB2|1R0E}}, {{PDB2|1UV5}}, {{PDB2|2JDO}}, {{PDB2|2JDR}}, {{PDB2|2JLD}}, {{PDB2|2O5K}}, {{PDB2|2OW3}}, {{PDB2|2X39}}, {{PDB2|2XH5}}, {{PDB2|3CQU}}, {{PDB2|3CQW}}, {{PDB2|3DU8}}, {{PDB2|3E87}}, {{PDB2|3E88}}, {{PDB2|3E8D}}, {{PDB2|3F7Z}}, {{PDB2|3F88}}, {{PDB2|3GB2}}, {{PDB2|3I4B}}, {{PDB2|3L1S}}, {{PDB2|3M1S}}, {{PDB2|3PUP}}, {{PDB2|3Q3B}}, {{PDB2|3SAY}}, {{PDB2|3SD0}}, {{PDB2|3ZRK}}, {{PDB2|3ZRL}}, {{PDB2|3ZRM}}, {{PDB2|4ACC}}, {{PDB2|4ACD}}, {{PDB2|4ACG}}, {{PDB2|4ACH}}, {{PDB2|4AFJ}}, {{PDB2|4DIT}}, {{PDB2|4EKK}}
 | HGNCid = 4617
 | MGIid = 1861437
 | Symbol = GSK3B
 | AltSymbols =
 | IUPHAR = 
 | ChEMBL = 262
 | OMIM = 605004
 | ECnumber = 2.7.11.1, 2.7.11.26
 | Homologene = 55629
 | GeneAtlas_image1 = PBB_GE_GSK3B_209945_s_at_tn.png
 | GeneAtlas_image2 = 
 | GeneAtlas_image3 = 
 | Protein_domain_image = 
 | Function = {{GNF_GO|id=GO:0001085 |text = RNA polymerase II transcription factor binding}} {{GNF_GO|id=GO:0002039 |text = p53 binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008013 |text = beta-catenin binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}} {{GNF_GO|id=GO:0031625 |text = ubiquitin protein ligase binding}} {{GNF_GO|id=GO:0034236 |text = protein kinase A catalytic subunit binding}} {{GNF_GO|id=GO:0050321 |text = tau-protein kinase activity}} {{GNF_GO|id=GO:0051059 |text = NF-kappaB binding}}
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005813 |text = centrosome}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0030877 |text = beta-catenin destruction complex}} {{GNF_GO|id=GO:0030877 |text = beta-catenin destruction complex}} {{GNF_GO|id=GO:0034747 |text = Axin-APC-beta-catenin-GSK3B complex}}
 | Process = {{GNF_GO|id=GO:0001837 |text = epithelial to mesenchymal transition}} {{GNF_GO|id=GO:0001954 |text = positive regulation of cell-matrix adhesion}} {{GNF_GO|id=GO:0005977 |text = glycogen metabolic process}} {{GNF_GO|id=GO:0006468 |text = protein phosphorylation}} {{GNF_GO|id=GO:0006983 |text = ER overload response}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0008543 |text = fibroblast growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0016310 |text = phosphorylation}} {{GNF_GO|id=GO:0018105 |text = peptidyl-serine phosphorylation}} {{GNF_GO|id=GO:0021766 |text = hippocampus development}} {{GNF_GO|id=GO:0031333 |text = negative regulation of protein complex assembly}} {{GNF_GO|id=GO:0031334 |text = positive regulation of protein complex assembly}} {{GNF_GO|id=GO:0032091 |text = negative regulation of protein binding}} {{GNF_GO|id=GO:0032855 |text = positive regulation of Rac GTPase activity}} {{GNF_GO|id=GO:0032886 |text = regulation of microtubule-based process}} {{GNF_GO|id=GO:0035556 |text = intracellular signal transduction}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptotic process}} {{GNF_GO|id=GO:0045719 |text = negative regulation of glycogen biosynthetic process}} {{GNF_GO|id=GO:0045732 |text = positive regulation of protein catabolic process}} {{GNF_GO|id=GO:0046827 |text = positive regulation of protein export from nucleus}} {{GNF_GO|id=GO:0048011 |text = nerve growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0048015 |text = phosphatidylinositol-mediated signaling}} {{GNF_GO|id=GO:0051534 |text = negative regulation of NFAT protein import into nucleus}} {{GNF_GO|id=GO:0060070 |text = canonical Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0060070 |text = canonical Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0071109 |text = superior temporal gyrus development}} {{GNF_GO|id=GO:0090090 |text = negative regulation of canonical Wnt receptor signaling pathway}} {{GNF_GO|id=GO:2000077 |text = negative regulation of type B pancreatic cell development}} {{GNF_GO|id=GO:2000466 |text = negative regulation of glycogen (starch) synthase activity}}
 | Hs_EntrezGene = 2932
 | Hs_Ensembl = ENSG00000082701
 | Hs_RefseqmRNA = NM_001146156.1
 | Hs_RefseqProtein = NP_001139628.1
 | Hs_GenLoc_db = hg19
 | Hs_GenLoc_chr = 3
 | Hs_GenLoc_start = 119540170
 | Hs_GenLoc_end = 119813264
 | Hs_Uniprot = P49841
 | Mm_EntrezGene = 56637
 | Mm_Ensembl = ENSMUSG00000022812
 | Mm_RefseqmRNA = NM_019827.6
 | Mm_RefseqProtein = NP_062801.1
 | Mm_GenLoc_db = mm9
 | Mm_GenLoc_chr = 16
 | Mm_GenLoc_start = 38089001
 | Mm_GenLoc_end = 38246084
 | Mm_Uniprot = Q9WV60
 | path = PBB/2932
}}