テンプレート:PBB/9353のソースを表示

{{GNF_Protein_box
 | Name = Slit guidance ligand 2
 | image =2v70.pdb
 | image_source = [[Protein_Data_Bank | PDB]] {{PDB2|2V70}}.による。
 | PDB = {{PDB2|2V70}}, {{PDB2|2V9S}}, {{PDB2|2V9T}}, {{PDB2|2WFH}}
 | HGNCid = 11086
 | MGIid = 1315205
 | Symbol = SLIT2
 | AltSymbols =; SLIL3; Slit-2
 | IUPHAR = 
 | ChEMBL = 
 | OMIM = 603746
 | ECnumber = 
 | Homologene = 3516
 | GeneAtlas_image1 = PBB_GE_SLIT2_209897_s_at_tn.png
 | GeneAtlas_image2 = 
 | GeneAtlas_image3 = 
 | Protein_domain_image = 
 | Function = {{GNF_GO|id=GO:0005095 |text = GTPase inhibitor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008201 |text = heparin binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0043237 |text = laminin-1 binding}} {{GNF_GO|id=GO:0043394 |text = proteoglycan binding}} {{GNF_GO|id=GO:0043395 |text = heparan sulfate proteoglycan binding}} {{GNF_GO|id=GO:0045499 |text = chemorepellent activity}} {{GNF_GO|id=GO:0048495 |text = Roundabout binding}}
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0070062 |text = extracellular exosome}}
 | Process = {{GNF_GO|id=GO:0001656 |text = metanephros development}} {{GNF_GO|id=GO:0001657 |text = ureteric bud development}} {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0001933 |text = negative regulation of protein phosphorylation}} {{GNF_GO|id=GO:0002042 |text = cell migration involved in sprouting angiogenesis}} {{GNF_GO|id=GO:0002689 |text = negative regulation of leukocyte chemotaxis}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0008045 |text = motor neuron axon guidance}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0010593 |text = negative regulation of lamellipodium assembly}} {{GNF_GO|id=GO:0010596 |text = negative regulation of endothelial cell migration}} {{GNF_GO|id=GO:0010629 |text = negative regulation of gene expression}} {{GNF_GO|id=GO:0014912 |text = negative regulation of smooth muscle cell migration}} {{GNF_GO|id=GO:0016337 |text = single organismal cell-cell adhesion}} {{GNF_GO|id=GO:0021510 |text = spinal cord development}} {{GNF_GO|id=GO:0021834 |text = chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration}} {{GNF_GO|id=GO:0021836 |text = chemorepulsion involved in postnatal olfactory bulb interneuron migration}} {{GNF_GO|id=GO:0021972 |text = corticospinal neuron axon guidance through spinal cord}} {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}} {{GNF_GO|id=GO:0030336 |text = negative regulation of cell migration}} {{GNF_GO|id=GO:0030517 |text = negative regulation of axon extension}} {{GNF_GO|id=GO:0030837 |text = negative regulation of actin filament polymerization}} {{GNF_GO|id=GO:0031290 |text = retinal ganglion cell axon guidance}} {{GNF_GO|id=GO:0031667 |text = response to nutrient levels}} {{GNF_GO|id=GO:0032870 |text = cellular response to hormone stimulus}} {{GNF_GO|id=GO:0033563 |text = dorsal/ventral axon guidance}} {{GNF_GO|id=GO:0034260 |text = negative regulation of GTPase activity}} {{GNF_GO|id=GO:0035385 |text = Roundabout signaling pathway}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptotic process}} {{GNF_GO|id=GO:0043116 |text = negative regulation of vascular permeability}} {{GNF_GO|id=GO:0048754 |text = branching morphogenesis of an epithelial tube}} {{GNF_GO|id=GO:0048846 |text = axon extension involved in axon guidance}} {{GNF_GO|id=GO:0050728 |text = negative regulation of inflammatory response}} {{GNF_GO|id=GO:0050772 |text = positive regulation of axonogenesis}} {{GNF_GO|id=GO:0050919 |text = negative chemotaxis}} {{GNF_GO|id=GO:0050929 |text = induction of negative chemotaxis}} {{GNF_GO|id=GO:0051058 |text = negative regulation of small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0051414 |text = response to cortisol}} {{GNF_GO|id=GO:0060763 |text = mammary duct terminal end bud growth}} {{GNF_GO|id=GO:0061364 |text = apoptotic process involved in luteolysis}} {{GNF_GO|id=GO:0070100 |text = negative regulation of chemokine-mediated signaling pathway}} {{GNF_GO|id=GO:0071504 |text = cellular response to heparin}} {{GNF_GO|id=GO:0071672 |text = negative regulation of smooth muscle cell chemotaxis}} {{GNF_GO|id=GO:0071676 |text = negative regulation of mononuclear cell migration}} {{GNF_GO|id=GO:0090024 |text = negative regulation of neutrophil chemotaxis}} {{GNF_GO|id=GO:0090027 |text = negative regulation of monocyte chemotaxis}} {{GNF_GO|id=GO:0090260 |text = negative regulation of retinal ganglion cell axon guidance}} {{GNF_GO|id=GO:0090288 |text = negative regulation of cellular response to growth factor stimulus}}
 | Hs_EntrezGene = 9353
 | Hs_Ensembl = ENSG00000145147
 | Hs_RefseqmRNA = NM_001289135
 | Hs_RefseqProtein = NP_001276064
 | Hs_GenLoc_db = hg38
 | Hs_GenLoc_chr = 4
 | Hs_GenLoc_start = 20253260
 | Hs_GenLoc_end = 20620561
 | Hs_Uniprot = O94813
 | Mm_EntrezGene = 20563
 | Mm_Ensembl = ENSMUSG00000031558
 | Mm_RefseqmRNA = NM_001291227
 | Mm_RefseqProtein = NP_001278156
 | Mm_GenLoc_db = mm10
 | Mm_GenLoc_chr = 5
 | Mm_GenLoc_start = 47983138
 | Mm_GenLoc_end = 48307733
 | Mm_Uniprot = Q9R1B9
 | path = PBB/9353
}}