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105 バイト追加 、 2012年1月22日 (日)
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{| style="width: 619px; height: 1446px;" border="1" cellspacing="1" cellpadding="1"
|+ 表1 主なS-パルミトイル化タンパク質<br>
|+ 表1 主なS-パルミトイル化タンパク質<br>  
{| style="width: 689px; height: 451px" border="1" cellspacing="1" cellpadding="1"
{| style="width: 587px; height: 457px;" border="1" cellspacing="1" cellpadding="1"
|-
|-
| ファミリー<br>
| ファミリー<br>  
| 主な例<br>
| 主な例<br>
|-
|-
| '''Signalling protein'''<br> Small GTPase<br> Gα subunit<br> Src family<br> Others<br>
| '''Signalling protein'''<br> Small GTPase<br> Gα subunit<br> Src family<br> Others<br>  
| <br>H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10<br>Gαs, Gαq, Gαi2<br>Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk<br>GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2<br>
| <br>H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10<br>Gαs, Gαq, Gαi2<br>Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk<br>GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2<br>
|-
|-
|  
|  
'''Transmembrane'''<br> Ion channel<br> GPCR<br> Cell adhesion molecule<br> Transporter<br> Matrix metalloproteinase<br> Myelin associated<br> Secretase<br> Cell death signalling<br>
'''Transmembrane'''<br> Ion channel<br> GPCR<br> Cell adhesion molecule<br> Transporter<br> Matrix metalloproteinase<br> Myelin associated<br> Secretase<br> Cell death signalling<br>  


| GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1<br>Rhodopsin, β2-adrenergic receptor, <br>Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC<br>EAAT1, EAAT3<br>MT1-MMP<br>PLP, GPM6A<br>β-secretase, Nicastrin<br>Fas, NGFR
| GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1<br>Rhodopsin, β2-adrenergic receptor, <br>Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC<br>EAAT1, EAAT3<br>MT1-MMP<br>PLP, GPM6A<br>β-secretase, Nicastrin<br>Fas, NGFR
|-
|-
| '''Adaptor, Scaffold'''<br>
| '''Adaptor, Scaffold'''<br>  
| PSD95, PSD93α/β, GRIP1/2, Delphilin<br>
| PSD95, PSD93α/β, GRIP1/2, Delphilin<br>
|-
|-
| '''Viral protein'''<br>
| '''Viral protein'''<br>  
| Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160<br>
| Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160<br>
|-
|-
| '''N-palmitoylated protein'''<br>
| '''N-palmitoylated protein'''<br>  
| Sonic Hedgehog, Wnt, Ghrelin <br>
| Sonic Hedgehog, Wnt, Ghrelin <br>
|}
|}


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<br>  
 
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表2 パルミチルトランスフェラーゼ


<br>


表2 パルミチルトランスフェラーゼ


|-
|-
39行目: 41行目:
| DHHC1  
| DHHC1  
| ZDHHC1  
| ZDHHC1  
| <br>
| <br>  
| ER  
| ER  
| <br>
| <br>
45行目: 47行目:
| DHHC2  
| DHHC2  
| ZDHHC2  
| ZDHHC2  
| PSD95, SNAP25, eNOS, Nde1, CD151, ABC transporter A1<br>
| PSD95, SNAP25, eNOS, Nde1, CD151, ABC transporter A1<br>  
| ER/ゴルジ体<br>
| ER/ゴルジ体<br>  
| 癌<br>
| 癌<br>
|-
|-
| DHHC3<br>
| DHHC3<br>  
|  
|  
ZDHHC3  
ZDHHC3  


GODZ<br>
GODZ<br>  


| PSD95, SNAP25, Gαs, GABAAγ2, eNOS,<br>
| PSD95, SNAP25, Gαs, GABAAγ2, eNOS,<br>  
| ゴルジ体<br>
| ゴルジ体<br>  
| <br>
| <br>
|-
|-
| DHHC4<br>
| DHHC4<br>  
| ZDHHC4<br>
| ZDHHC4<br>  
| BACE1<br>
| BACE1<br>  
| ゴルジ体<br>
| ゴルジ体<br>  
| <br>
| <br>
|-
|-
| DHHC5<br>
| DHHC5<br>  
| ZDHHC5<br>
| ZDHHC5<br>  
| STREX<br>
| STREX<br>  
| <br>
| <br>  
| <br>
| <br>
|-
|-
| DHHC6<br>
| DHHC6<br>  
| ZDHHC6<br>
| ZDHHC6<br>  
| <br>
| <br>  
| <br>
| <br>  
| <br>
| <br>
|-
|-
| DHHC7<br>
| DHHC7<br>  
| ZDHHC7<br>
| ZDHHC7<br>  
| PSD95, SNAP25, Gαs, GAP43, GABAAγ2, eNOS<br>
| PSD95, SNAP25, Gαs, GAP43, GABAAγ2, eNOS<br>  
| ゴルジ体<br>
| ゴルジ体<br>  
| <br>
| <br>
|-
|-
| DHHC8<br>
| DHHC8<br>  
| ZDHHC8<br>
| ZDHHC8<br>  
| PSD95, SNAP25, eNOS, paralemmin-1<br>
| PSD95, SNAP25, eNOS, paralemmin-1<br>  
| ゴルジ体<br>
| ゴルジ体<br>  
| 統合失調症<br>
| 統合失調症<br>
|-
|-
| DHHC9'''<br>'''
| DHHC9'''<br>'''  
| ZDHHC9<br>
| ZDHHC9<br>  
| H-RAS, N-Ras<br>
| H-RAS, N-Ras<br>  
| ER/ゴルジ体<br>
| ER/ゴルジ体<br>  
| 癌、X連鎖神経遅滞<br>
| 癌、X連鎖神経遅滞<br>
|-
|-
| DHHC10<br>
| DHHC10<br>  
| ZDHHC11<br>
| ZDHHC11<br>  
| <br>
| <br>  
| ER<br>
| ER<br>  
| <br>
| <br>
|-
|-
| DHHC11<br>
| DHHC11<br>  
| ZDHHC23<br>NIDD<br>
| ZDHHC23<br>NIDD<br>  
| <br>
| <br>  
| ER<br>
| ER<br>  
| 癌<br>
| 癌<br>
|-
|-
| DHHC12<br>
| DHHC12<br>  
| ZDHHC12<br>
| ZDHHC12<br>  
| ABC transporter A1<br>
| ABC transporter A1<br>  
| ER/ゴルジ体<br>
| ER/ゴルジ体<br>  
| <br>
| <br>
|-
|-
| DHHC13<br>
| DHHC13<br>  
| ZDHHC24<br>
| ZDHHC24<br>  
| huntingtin<br>
| huntingtin<br>  
| ER<br>
| ER<br>  
| <br>
| <br>
|-
|-
| DHHC14<br>
| DHHC14<br>  
| ZDHHC14<br>
| ZDHHC14<br>  
| <br>
| <br>  
| ER<br>
| ER<br>  
| <br>
| <br>
|-
|-
| DHHC15<br>
| DHHC15<br>  
| ZDHHC15<br>
| ZDHHC15<br>  
| PSD95, GAP43, GABAAγ2, BACE1, CD151<br>
| PSD95, GAP43, GABAAγ2, BACE1, CD151<br>  
| ゴルジ体<br>
| ゴルジ体<br>  
| X連鎖神経遅滞<br>
| X連鎖神経遅滞<br>
|-
|-
| DHHC16<br>
| DHHC16<br>  
| ZDHHC16<br>
| ZDHHC16<br>  
| <br>
| <br>  
| ER<br>
| ER<br>  
| <br>
| <br>
|-
|-
| DHHC17<br>
| DHHC17<br>  
|  
|  
ZDHHC17  
ZDHHC17  


HIP14<br>
HIP14<br>  


| SNAP25, huntingtin, <br>
| SNAP25, huntingtin, <br>  
| ゴルジ体<br>
| ゴルジ体<br>  
| ハンチントン病、癌<br>
| ハンチントン病、癌<br>
|-
|-
| DHHC18<br>
| DHHC18<br>  
| ZDHHC18<br>
| ZDHHC18<br>  
| <br>
| <br>  
| ゴルジ体<br>
| ゴルジ体<br>  
| <br>
| <br>
|-
|-
| DHHC19<br>
| DHHC19<br>  
| ZDHHC19<br>
| ZDHHC19<br>  
| R-Ras<br>
| R-Ras<br>  
| ER<br>
| ER<br>  
| <br>
| <br>
|-
|-
| DHHC20<br>
| DHHC20<br>  
| ZDHHC20<br>
| ZDHHC20<br>  
| BACE1, ABC transporter 1<br>
| BACE1, ABC transporter 1<br>  
| 細胞膜<br>
| 細胞膜<br>  
| <br>
| <br>
|-
|-
| DHHC21<br>
| DHHC21<br>  
| ZDHHC21<br>
| ZDHHC21<br>  
| eNOS, Lck, Fyn, ABC transporter 1<br>
| eNOS, Lck, Fyn, ABC transporter 1<br>  
| 細胞膜<br>
| 細胞膜<br>  
| <br>
| <br>
|-
|-
| DHHC22<br>
| DHHC22<br>  
| ZDHHC13<br>
| ZDHHC13<br>  
| <br>
| <br>  
| ER/ゴルジ体<br>
| ER/ゴルジ体<br>  
| <br>
| <br>
|-
|-
| DHHC23<br>
| DHHC23<br>  
| ZDHHC25<br>
| ZDHHC25<br>  
| <br>
| <br>  
| <br>
| <br>  
| <br>
| <br>
|-
|-
| <br>
| <br>  
| ZDHHC22<br>
| ZDHHC22<br>  
| <br>
| <br>  
| <br>
| <br>  
| <br>
| <br>
|}
|}


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