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2012年1月22日 (日) 17:54時点における版

1,032 バイト追加 、 2012年1月22日 (日)
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{| style="width: 619px; height: 1446px" border="1" cellspacing="1" cellpadding="1"
|+ 表1 主なS-パルミトイル化タンパク質<br>  
|+ 表1 主なS-パルミトイル化タンパク質<br>
{| style="width: 587px; height: 457px;" border="1" cellspacing="1" cellpadding="1"
{| style="width: 587px; height: 457px" border="1" cellspacing="1" cellpadding="1"
|-
|-
| ファミリー<br>  
| ファミリー<br>
| 主な例<br>
| 主な例<br>
|-
|-
| '''Signalling protein'''<br>　Small GTPase<br>　Gα subunit<br>　Src family<br>　Others<br>  
| '''Signalling protein'''<br>　Small GTPase<br>　Gα subunit<br>　Src family<br>　Others<br>
| <br>H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10<br>Gαs, Gαq, Gαi2<br>Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk<br>GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2<br>
| <br>H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10<br>Gαs, Gαq, Gαi2<br>Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk<br>GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2<br>
|-
|-
|  
|  
'''Transmembrane'''<br>　Ion channel<br>　GPCR<br>　Cell adhesion molecule<br>　Transporter<br>　Matrix metalloproteinase<br>　Myelin associated<br>　Secretase<br>　Cell death signalling<br>  
'''Transmembrane'''<br>　Ion channel<br>　GPCR<br>　Cell adhesion molecule<br>　Transporter<br>　Matrix metalloproteinase<br>　Myelin associated<br>　Secretase<br>　Cell death signalling<br>


| GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1<br>Rhodopsin, β2-adrenergic receptor, <br>Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC<br>EAAT1, EAAT3<br>MT1-MMP<br>PLP, GPM6A<br>β-secretase, Nicastrin<br>Fas, NGFR
| GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1<br>Rhodopsin, β2-adrenergic receptor, <br>Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC<br>EAAT1, EAAT3<br>MT1-MMP<br>PLP, GPM6A<br>β-secretase, Nicastrin<br>Fas, NGFR
|-
|-
| '''Adaptor, Scaffold'''<br>  
| '''Adaptor, Scaffold'''<br>
| PSD95, PSD93α/β, GRIP1/2, Delphilin<br>
| PSD95, PSD93α/β, GRIP1/2, Delphilin<br>
|-
|-
| '''Viral protein'''<br>  
| '''Viral protein'''<br>
| Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160<br>
| Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160<br>
|-
|-
| '''N-palmitoylated protein'''<br>  
| '''N-palmitoylated protein'''<br>
| Sonic Hedgehog, Wnt, Ghrelin <br>
| Sonic Hedgehog, Wnt, Ghrelin <br>
|}
|}


<br>  
<br>


<br>  
<br>


表２ パルミチルトランスフェラーゼ  
表２ パルミチルトランスフェラーゼ  
<br>




41行目: 43行目:
| DHHC1  
| DHHC1  
| ZDHHC1  
| ZDHHC1  
| <br>  
| <br>
| ER  
| ER  
| <br>
| <br>
47行目: 49行目:
| DHHC2  
| DHHC2  
| ZDHHC2  
| ZDHHC2  
| PSD95, SNAP25, eNOS, Nde1, CD151, ABC transporter A1<br>  
| PSD95, SNAP25, eNOS, Nde1, CD151, ABC transporter A1<br>
| ER/ゴルジ体<br>  
| ER/ゴルジ体<br>
| 癌<br>
| 癌<br>
|-
|-
| DHHC3<br>  
| DHHC3<br>
|  
|  
ZDHHC3  
ZDHHC3  


GODZ<br>  
GODZ<br>


| PSD95, SNAP25, Gαs, GABAAγ2, eNOS,<br>  
| PSD95, SNAP25, Gαs, GABAAγ2, eNOS,<br>
| ゴルジ体<br>  
| ゴルジ体<br>
| <br>
| <br>
|-
|-
| DHHC4<br>  
| DHHC4<br>
| ZDHHC4<br>  
| ZDHHC4<br>
| BACE1<br>  
| BACE1<br>
| ゴルジ体<br>  
| ゴルジ体<br>
| <br>
| <br>
|-
|-
| DHHC5<br>  
| DHHC5<br>
| ZDHHC5<br>  
| ZDHHC5<br>
| STREX<br>  
| STREX<br>
| <br>  
| <br>
| <br>
| <br>
|-
|-
| DHHC6<br>  
| DHHC6<br>
| ZDHHC6<br>  
| ZDHHC6<br>
| <br>  
| <br>
| <br>  
| <br>
| <br>
| <br>
|-
|-
| DHHC7<br>  
| DHHC7<br>
| ZDHHC7<br>  
| ZDHHC7<br>
| PSD95, SNAP25, Gαs, GAP43, GABAAγ2, eNOS<br>  
| PSD95, SNAP25, Gαs, GAP43, GABAAγ2, eNOS<br>
| ゴルジ体<br>  
| ゴルジ体<br>
| <br>
| <br>
|-
|-
| DHHC8<br>  
| DHHC8<br>
| ZDHHC8<br>  
| ZDHHC8<br>
| PSD95, SNAP25, eNOS, paralemmin-1<br>  
| PSD95, SNAP25, eNOS, paralemmin-1<br>
| ゴルジ体<br>  
| ゴルジ体<br>
| 統合失調症<br>
| 統合失調症<br>
|-
|-
| DHHC9'''<br>'''  
| DHHC9'''<br>'''
| ZDHHC9<br>  
| ZDHHC9<br>
| H-RAS, N-Ras<br>  
| H-RAS, N-Ras<br>
| ER/ゴルジ体<br>  
| ER/ゴルジ体<br>
| 癌、X連鎖神経遅滞<br>
| 癌、X連鎖神経遅滞<br>
|-
|-
| DHHC10<br>  
| DHHC10<br>
| ZDHHC11<br>  
| ZDHHC11<br>
| <br>  
| <br>
| ER<br>  
| ER<br>
| <br>
| <br>
|-
|-
| DHHC11<br>  
| DHHC11<br>
| ZDHHC23<br>NIDD<br>  
| ZDHHC23<br>NIDD<br>
| <br>  
| <br>
| ER<br>  
| ER<br>
| 癌<br>
| 癌<br>
|-
|-
| DHHC12<br>  
| DHHC12<br>
| ZDHHC12<br>  
| ZDHHC12<br>
| ABC transporter A1<br>  
| ABC transporter A1<br>
| ER/ゴルジ体<br>  
| ER/ゴルジ体<br>
| <br>
| <br>
|-
|-
| DHHC13<br>  
| DHHC13<br>
| ZDHHC24<br>  
| ZDHHC24<br>
| huntingtin<br>  
| huntingtin<br>
| ER<br>  
| ER<br>
| <br>
| <br>
|-
|-
| DHHC14<br>  
| DHHC14<br>
| ZDHHC14<br>  
| ZDHHC14<br>
| <br>  
| <br>
| ER<br>  
| ER<br>
| <br>
| <br>
|-
|-
| DHHC15<br>  
| DHHC15<br>
| ZDHHC15<br>  
| ZDHHC15<br>
| PSD95, GAP43, GABAAγ2, BACE1, CD151<br>  
| PSD95, GAP43, GABAAγ2, BACE1, CD151<br>
| ゴルジ体<br>  
| ゴルジ体<br>
| X連鎖神経遅滞<br>
| X連鎖神経遅滞<br>
|-
|-
| DHHC16<br>  
| DHHC16<br>
| ZDHHC16<br>  
| ZDHHC16<br>
| <br>  
| <br>
| ER<br>  
| ER<br>
| <br>
| <br>
|-
|-
| DHHC17<br>  
| DHHC17<br>
|  
|  
ZDHHC17  
ZDHHC17  


HIP14<br>  
HIP14<br>


| SNAP25, huntingtin, <br>  
| SNAP25, huntingtin, <br>
| ゴルジ体<br>  
| ゴルジ体<br>
| ハンチントン病、癌<br>
| ハンチントン病、癌<br>
|-
|-
| DHHC18<br>  
| DHHC18<br>
| ZDHHC18<br>  
| ZDHHC18<br>
| <br>  
| <br>
| ゴルジ体<br>  
| ゴルジ体<br>
| <br>
| <br>
|-
|-
| DHHC19<br>  
| DHHC19<br>
| ZDHHC19<br>  
| ZDHHC19<br>
| R-Ras<br>  
| R-Ras<br>
| ER<br>  
| ER<br>
| <br>
| <br>
|-
|-
| DHHC20<br>  
| DHHC20<br>
| ZDHHC20<br>  
| ZDHHC20<br>
| BACE1, ABC transporter 1<br>  
| BACE1, ABC transporter 1<br>
| 細胞膜<br>  
| 細胞膜<br>
| <br>
| <br>
|-
|-
| DHHC21<br>  
| DHHC21<br>
| ZDHHC21<br>  
| ZDHHC21<br>
| eNOS, Lck, Fyn, ABC transporter 1<br>  
| eNOS, Lck, Fyn, ABC transporter 1<br>
| 細胞膜<br>  
| 細胞膜<br>
| <br>
| <br>
|-
|-
| DHHC22<br>  
| DHHC22<br>
| ZDHHC13<br>  
| ZDHHC13<br>
| <br>  
| <br>
| ER/ゴルジ体<br>  
| ER/ゴルジ体<br>
| <br>
| <br>
|-
|-
| DHHC23<br>  
| DHHC23<br>
| ZDHHC25<br>  
| ZDHHC25<br>
| <br>  
| <br>
| <br>  
| <br>
| <br>
| <br>
|-
|-
| <br>  
| <br>
| ZDHHC22<br>  
| ZDHHC22<br>
| <br>  
| <br>
| <br>  
| <br>
| <br>
| <br>
|}
|}


&nbsp; <br>
&nbsp; <br>
{| style="width: 618px; height: 1074px" border="1" cellspacing="1" cellpadding="1" width="618"
|-
| Category
| Family
| N-Myristoylated protein
|-
| Kinase/Phosphatase
| Src family kinase
| Src, Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk, Blk
|-
|
| Abl tyrosine kinase
| c-Abl, Arg
|-
| <br>
| Ser/Thr kinase
| cAMP-dependent protein kinase, AKAP18
|-
| <br>
| phosphatase
| Calcineurin B
|-
| GTP-binding protein
| Gα
| Gα i1, Gαo, Gαt, Gαx
|-
|
| ADP-ribosylation factor
| Arf-1, Arf-3, Arf-5, Arf-6
|-
| Ca2+ binding /<br>EF hand protein
|
| Recoverin, Neurocalcin, Aplycalcin, P22, NAP-22,<br>Hippocalcin, GCAP1, GCAP2, S-Modulin, Rem-1
|-
| Membrane/cytoskeletal-<br>bound protein
|
| MARCKS, Annexin　XIII, <br>Rapsyn, Pallidin, Hisactophilin 2
|-
| Viral protein
| Gag protein
| HIV-1, Moloney murine, sarcoma virus, Friend murine,<br>leukemia virus
|-
|
| Others
| HIV-1 Nef, Duck hepatitis B virus, Rhinovirus 16,<br>Herpes simplex virus
|-
| Others
|
| eNOS
|-
| Caspase-cleavage <br>post-translational<br>N-myristoylated protein
|
| β-actin, BID, Gelsolin, PAK2, p28 Bap31, CD-IC2A, GCL,<br>MST3, PKC,
|}
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