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{{GNF_Protein_box | |||
| Name = Hypocretin (orexin) neuropeptide precursor | |||
| image = | |||
| image_source = | |||
| PDB = {{PDB2|1CQ0}}, {{PDB2|1R02}}, {{PDB2|1UVQ}}, {{PDB2|1WSO}} | |||
| HGNCid = 4847 | |||
| MGIid = | |||
| Symbol = HCRT | |||
| AltSymbols =; NRCLP1; OX; PPOX | |||
| IUPHAR = | |||
| ChEMBL = | |||
| OMIM = 602358 | |||
| ECnumber = | |||
| Homologene = 1166 | |||
| GeneAtlas_image1 = | |||
| GeneAtlas_image2 = | |||
| GeneAtlas_image3 = | |||
| Protein_domain_image = | |||
| Function = {{GNF_GO|id=GO:0005184 |text = neuropeptide hormone activity}} {{GNF_GO|id=GO:0031771 |text = type 1 hypocretin receptor binding}} {{GNF_GO|id=GO:0031772 |text = type 2 hypocretin receptor binding}} | |||
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005791 |text = rough endoplasmic reticulum}} {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}} {{GNF_GO|id=GO:0030054 |text = cell junction}} {{GNF_GO|id=GO:0030141 |text = secretory granule}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}} | |||
| Process = {{GNF_GO|id=GO:0007200 |text = phospholipase C-activating G-protein coupled receptor signaling pathway}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0007205 |text = protein kinase C-activating G-protein coupled receptor signaling pathway}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0008156 |text = negative regulation of DNA replication}} {{GNF_GO|id=GO:0042755 |text = eating behavior}} {{GNF_GO|id=GO:0043267 |text = negative regulation of potassium ion transport}} {{GNF_GO|id=GO:0046928 |text = regulation of neurotransmitter secretion}} {{GNF_GO|id=GO:0051928 |text = positive regulation of calcium ion transport}} {{GNF_GO|id=GO:0051970 |text = negative regulation of transmission of nerve impulse}} {{GNF_GO|id=GO:0051971 |text = positive regulation of transmission of nerve impulse}} {{GNF_GO|id=GO:0060079 |text = regulation of excitatory postsynaptic membrane potential}} | |||
| Hs_EntrezGene = 3060 | |||
| Hs_Ensembl = ENSG00000161610 | |||
| Hs_RefseqmRNA = NM_001524 | |||
| Hs_RefseqProtein = NP_001515 | |||
| Hs_GenLoc_db = hg19 | |||
| Hs_GenLoc_chr = 17 | |||
| Hs_GenLoc_start = 40336078 | |||
| Hs_GenLoc_end = 40337470 | |||
| Hs_Uniprot = O43612 | |||
| Mm_EntrezGene = 15171 | |||
| Mm_Ensembl = ENSMUSG00000045471 | |||
| Mm_RefseqmRNA = NM_010410 | |||
| Mm_RefseqProtein = NP_034540 | |||
| Mm_GenLoc_db = mm9 | |||
| Mm_GenLoc_chr = 11 | |||
| Mm_GenLoc_start = 100761069 | |||
| Mm_GenLoc_end = 100762931 | |||
| Mm_Uniprot = O55241 | |||
| path = PBB/3060 | |||
}} | |||
英語名：orexin A, orexin B | 英語名：orexin A, orexin B | ||