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コーニション (ソースを閲覧)

2016年2月2日 (火) 13:17時点における版

7,603 バイト追加 、 2016年2月2日 (火)
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　コーニションは酵母から哺乳類まで保存されているタンパク質ファミリーである<ref name=ref1><pubmed>16396907</pubmed></ref>。その一部は、イオンチャネル型のグルタミン酸受容体と特異的に結合し、補助サブユニットとしてチャネル活性や細胞膜発現を制御すると考えられている。哺乳類CNIH2/3はAMPA型グルタミン酸受容体と結合しチャネル活性を制御することが<ref name=ref2><pubmed>    19265014</pubmed></ref> <ref name=ref3><pubmed>23522044</pubmed></ref>、線虫ホモログのCNI-1は グルタミン酸受容体GLR-1の局在を調整することが報告されている<ref name=ref4><pubmed>24094107</pubmed></ref>。
　コーニションは酵母から哺乳類まで保存されているタンパク質ファミリーである<ref name=ref1><pubmed>16396907</pubmed></ref>。その一部は、イオンチャネル型のグルタミン酸受容体と特異的に結合し、補助サブユニットとしてチャネル活性や細胞膜発現を制御すると考えられている。哺乳類CNIH2/3はAMPA型グルタミン酸受容体と結合しチャネル活性を制御することが<ref name=ref2><pubmed>    19265014</pubmed></ref> <ref name=ref3><pubmed>23522044</pubmed></ref>、線虫ホモログのCNI-1は グルタミン酸受容体GLR-1の局在を調整することが報告されている<ref name=ref4><pubmed>24094107</pubmed></ref>。
}}
{{GNF_Protein_box
| Name = Cornichon family AMPA receptor auxiliary protein 3
| image =
| image_source =
| PDB =
| HGNCid = 26802
| MGIid =
| Symbol = CNIH3
| AltSymbols =; CNIH-3
| IUPHAR =
| ChEMBL =
| OMIM = None
| ECnumber =
| Homologene =
| GeneAtlas_image1 =
| GeneAtlas_image2 =
| GeneAtlas_image3 =
| Protein_domain_image =
| Function = {{GNF_GO|id=GO:0016247 |text = channel regulator activity}}
| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0005789 |text = endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0012507 |text = ER to Golgi transport vesicle membrane}} {{GNF_GO|id=GO:0030054 |text = cell junction}} {{GNF_GO|id=GO:0032281 |text = AMPA glutamate receptor complex}} {{GNF_GO|id=GO:0033116 |text = endoplasmic reticulum-Golgi intermediate compartment membrane}} {{GNF_GO|id=GO:0043198 |text = dendritic shaft}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0018279 |text = protein N-linked glycosylation via asparagine}} {{GNF_GO|id=GO:0035249 |text = synaptic transmission, glutamatergic}} {{GNF_GO|id=GO:0035556 |text = intracellular signal transduction}} {{GNF_GO|id=GO:0042391 |text = regulation of membrane potential}} {{GNF_GO|id=GO:0043687 |text = post-translational protein modification}} {{GNF_GO|id=GO:0044267 |text = cellular protein metabolic process}} {{GNF_GO|id=GO:0048208 |text = COPII vesicle coating}} {{GNF_GO|id=GO:0061024 |text = membrane organization}} {{GNF_GO|id=GO:2000311 |text = regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity}}
| Hs_EntrezGene = 149111
| Hs_Ensembl = ENSG00000143786
| Hs_RefseqmRNA = NM_152495
| Hs_RefseqProtein = NP_689708
| Hs_GenLoc_db = hg38
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 224434660
| Hs_GenLoc_end = 224740549
| Hs_Uniprot = Q8TBE1
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
| path = PBB/149111
}}
{{GNF_Protein_box
| Name = Cornichon family AMPA receptor auxiliary protein 1
| image =
| image_source =
| PDB =
| HGNCid = 19431
| MGIid = 1277202
| Symbol = CNIH1
| AltSymbols =; CNIH; CNIH-1; CNIL; TGAM77
| IUPHAR =
| ChEMBL =
| OMIM = 611287
| ECnumber =
| Homologene = 4219
| GeneAtlas_image1 = PBB_GE_CNIH_201653_at_tn.png
| GeneAtlas_image2 =
| GeneAtlas_image3 =
| Protein_domain_image =
| Function =
| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0005789 |text = endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0016021 |text = integral component of membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}} {{GNF_GO|id=GO:0035556 |text = intracellular signal transduction}}
| Hs_EntrezGene = 10175
| Hs_Ensembl = ENSG00000100528
| Hs_RefseqmRNA = NM_001009551
| Hs_RefseqProtein = NP_005767
| Hs_GenLoc_db = hg38
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 54423560
| Hs_GenLoc_end = 54441431
| Hs_Uniprot = O95406
| Mm_EntrezGene = 12793
| Mm_Ensembl = ENSMUSG00000015759
| Mm_RefseqmRNA = NM_009919
| Mm_RefseqProtein = NP_034049
| Mm_GenLoc_db = mm10
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 46775582
| Mm_GenLoc_end = 46788411
| Mm_Uniprot = O35372
| path = PBB/10175
}}
{{GNF_Protein_box
| Name = Cornichon family AMPA receptor auxiliary protein 2
| image =
| image_source =
| PDB =
| HGNCid = 28744
| MGIid =
| Symbol = CNIH2
| AltSymbols =; CNIH-2; Cnil
| IUPHAR =
| ChEMBL =
| OMIM = 611288
| ECnumber =
| Homologene =
| GeneAtlas_image1 =
| GeneAtlas_image2 =
| GeneAtlas_image3 =
| Protein_domain_image =
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0005789 |text = endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0012507 |text = ER to Golgi transport vesicle membrane}} {{GNF_GO|id=GO:0014069 |text = postsynaptic density}} {{GNF_GO|id=GO:0030054 |text = cell junction}} {{GNF_GO|id=GO:0030425 |text = dendrite}} {{GNF_GO|id=GO:0032281 |text = AMPA glutamate receptor complex}} {{GNF_GO|id=GO:0033116 |text = endoplasmic reticulum-Golgi intermediate compartment membrane}} {{GNF_GO|id=GO:0043197 |text = dendritic spine}} {{GNF_GO|id=GO:0043198 |text = dendritic shaft}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0018279 |text = protein N-linked glycosylation via asparagine}} {{GNF_GO|id=GO:0035249 |text = synaptic transmission, glutamatergic}} {{GNF_GO|id=GO:0035556 |text = intracellular signal transduction}} {{GNF_GO|id=GO:0042391 |text = regulation of membrane potential}} {{GNF_GO|id=GO:0043687 |text = post-translational protein modification}} {{GNF_GO|id=GO:0044267 |text = cellular protein metabolic process}} {{GNF_GO|id=GO:0048208 |text = COPII vesicle coating}} {{GNF_GO|id=GO:0061024 |text = membrane organization}} {{GNF_GO|id=GO:1902684 |text = negative regulation of receptor localization to synapse}} {{GNF_GO|id=GO:1903743 |text = negative regulation of anterograde synaptic vesicle transport}} {{GNF_GO|id=GO:2000310 |text = regulation of N-methyl-D-aspartate selective glutamate receptor activity}} {{GNF_GO|id=GO:2000311 |text = regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity}}
| Hs_EntrezGene = 254263
| Hs_Ensembl = ENSG00000174871
| Hs_RefseqmRNA = NM_182553
| Hs_RefseqProtein = NP_872359
| Hs_GenLoc_db = hg38
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 66278190
| Hs_GenLoc_end = 66285301
| Hs_Uniprot = Q6PI25
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
| path = PBB/254263
}}
{{GNF_Protein_box
| Name = Cornichon family AMPA receptor auxiliary protein 4
| image =
| image_source =
| PDB =
| HGNCid = 25013
| MGIid = 1925828
| Symbol = CNIH4
| AltSymbols =; CNIH-4; HSPC163
| IUPHAR =
| ChEMBL =
| OMIM =
| ECnumber =
| Homologene = 5932
| GeneAtlas_image1 = PBB_GE_CNIH4_218728_s_at_tn.png
| GeneAtlas_image2 =
| GeneAtlas_image3 =
| Protein_domain_image =
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0031730 |text = CCR5 chemokine receptor binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005793 |text = endoplasmic reticulum-Golgi intermediate compartment}} {{GNF_GO|id=GO:0016021 |text = integral component of membrane}}
| Process = {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0035556 |text = intracellular signal transduction}}
| Hs_EntrezGene = 29097
| Hs_Ensembl = ENSG00000143771
| Hs_RefseqmRNA = NM_001277197
| Hs_RefseqProtein = NP_001264126
| Hs_GenLoc_db = hg38
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 224356850
| Hs_GenLoc_end = 224379459
| Hs_Uniprot = Q9P003
| Mm_EntrezGene = 98417
| Mm_Ensembl = ENSMUSG00000062169
| Mm_RefseqmRNA = NM_030131
| Mm_RefseqProtein = NP_084407
| Mm_GenLoc_db = mm10
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 181144693
| Mm_GenLoc_end = 181168994
| Mm_Uniprot = Q9CX13
| path = PBB/29097
}}
}}


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