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{| class="wikitable" |+ 表1. |- | Classification||Target ||Year||Probe design ||References |- | Small molecule || Calcium || 1997 || 3-2 || <ref><pubmed>9278050</pubmed></ref> |- | Small molecule || Cyclic guanosine monophosphate (cGMP) || 2000, 2001, 2006 || 3-1 || <ref><pubmed>111407578</pubmed></ref><ref><pubmed>11226257</pubmed></ref><ref><pubmed>16369548</pubmed></ref> |- | Small molecule || Cyclic adenosine monophosphate (cAMP) || 2000,2004 || 2, 3-1 || <ref><pubmed>11872839</pubmed></ref><ref><pubmed> 15231839</pubmed></ref> |- | Small molecule || Inositol trisphosphate (IP3) || 2004, 2005, 2006 || 3-1 || <ref><pubmed>15272011</pubmed></ref><ref><pubmed> 16053285</pubmed></ref><ref><pubmed> 16754959</pubmed></ref> |- | Small molecule || Nitric oxide (NO) || 2005, 2006 || 3-1 || <ref><pubmed>16176986</pubmed></ref><ref><pubmed> 17165805</pubmed></ref> |- | Small molecule || Adenosine triphosphate (ATP) || 2012 || 3-1 || <ref><pubmed>19720993</pubmed></ref> |- | Small molecule || Estrogen || 2004 || 3-3 || <ref><pubmed>15080726</pubmed></ref> |- | Small molecule || Androgen || 2006 || 3-3 || <ref><pubmed>16555356</pubmed></ref> |- | Small molecule || Glucocorticoid receptor ligands || 2007 || 3-3 || <ref><pubmed>17897691</pubmed></ref> |- | Small molecule || Neurotrophic factor || 2008 || 3-3 || <ref><pubmed>18510313</pubmed></ref> |- | Small molecule || Nuclear receptor || 2007 || 3-2 || <ref><pubmed>17387660</pubmed></ref> |- | Small molecule || O-N-acetylglucosamine (O-GlcNAc) || 2006 || 3-3 || <ref><pubmed>17105262</pubmed></ref> |- | Small molecule || Vitamin A (Retinoic acid) || 2013 || 3-1 || <ref><pubmed>23563268</pubmed></ref> |- | Small molecule || Molybdate || 2013 || 3-1 || <ref><pubmed>23472155</pubmed></ref> |- | Small molecule || Glutamate || 2005 || 3-1 || <ref><pubmed>15939876</pubmed></ref> |- | Small molecule || Zn2+ || 2009 || 2 || <ref><pubmed>19718032</pubmed></ref> |- | Small molecule || Cl- || 2000 || other || <ref><pubmed>11055428</pubmed></ref> |- | Small molecule || pH || 2001 || other || <ref><pubmed>11716495</pubmed></ref> |- | Small molecule || Glucose || 2003 || 3-1 || <ref><pubmed>12649277</pubmed></ref> |- | Small molecule || Maltose || 2002 || 3-1 || <ref><pubmed>12097642</pubmed></ref> |- | Small molecule || Ribose || 2003 || 3-1 || <ref><pubmed>14550551</pubmed></ref> |- | Kinase || Calcium/Calmodulin-dependent protein kinase II (CaMKII) || 2005, 2009, 2011, 2013 || 3-1 || <ref><pubmed>15788767</pubmed></ref><ref><pubmed> 19295602</pubmed></ref><ref><pubmed> 23602566</pubmed></ref><ref><pubmed> 21506563</pubmed></ref> |- | Kinase || Src || 2005, 2005, 2007 || 3-3 || <ref><pubmed>11752449</pubmed></ref><ref><pubmed> 15846350</pubmed></ref><ref><pubmed> 17284441</pubmed></ref> |- | Kinase || Protein kinase C (PKC) || 2003, 2005 || 3-3, 3-1 || <ref><pubmed>12782683</pubmed></ref><ref><pubmed> 15611119</pubmed></ref> |- | Kinase || Protein kinase D (PKD) || 2007 || 3-3 || <ref><pubmed>17189263</pubmed></ref> |- | Kinase || Protein kinase A (PKA) || 2000, 2001 || 3-3 || <ref><pubmed>10700148, 11752448</pubmed></ref> |- Table 1 A list of genetically encoded FRET probes. | Kinase || Abl || 2001 || 3-3 || <ref><pubmed>11752449</pubmed></ref> |- | Kinase || Bcr-Abl || 2010 || 3-3 || <ref><pubmed>20817824</pubmed></ref> |- The numbers in the Probe Design column correspond to the section number in the “Strategies of probe design” chapter of the main text. See the webpage by Dr. Michiyuki Matsuda http://www.lif.kyoto-u.ac.jp/labs/fret/e-phogemon/unifret.htm for updated information. | Kinase || c-Raf || 2005 || 3-1 || <ref><pubmed>15711535</pubmed></ref> |- | Kinase || PAK1 || 2009 || 3-1 || <ref><pubmed>19574218</pubmed></ref> |- | Kinase || B-raf || 2006 || 3-1 || <ref><pubmed>16858395</pubmed></ref> |- | Kinase || ZAP-70 || 2008 || 3-3 || <ref><pubmed>18231606</pubmed></ref> |- | Kinase || Akt || 2003, 2005, 2007 || 3-3 || <ref><pubmed>12773546</pubmed></ref><ref><pubmed> 15583002</pubmed></ref><ref><pubmed> 17407381</pubmed></ref> |- | Kinase || ERK || 2006, 2007, 2008 || 3-1,3-3,3-3 || <ref><pubmed>16418172</pubmed></ref><ref><pubmed> 17261026</pubmed></ref><ref><pubmed> 19033456</pubmed></ref> |- | Kinase || Insulin receptor || 2002 || 3-3 || <ref><pubmed>11875431</pubmed></ref> |- | Kinase || Epidermal Growth factor receptor (EGFR) || 2001 || 3-3 || <ref><pubmed>11752449</pubmed></ref> |- | Kinase || Ataxia telangiectasia mutated (ATM) || 2007 || 3-3 || <ref><pubmed>17428747</pubmed></ref> |- | Kinase || Aurora B kinase || 2008 || 3-3 || <ref><pubmed>18463638</pubmed></ref> |- | Kinase || Cyclin B1-CDK1 || 2010 || 3-3 || <ref><pubmed>20412769</pubmed></ref> |- | Kinase || Myosine light chain kinase || 2002 || 3-1 || <ref><pubmed>11815633</pubmed></ref> |- | Kinase || JNK || 2010, 2011 || 3-3 || <ref><pubmed>20212108</pubmed></ref><ref><pubmed> 21976697</pubmed></ref> |- | Kinase || RSK || 2011 || 3-3 || <ref><pubmed>21976697</pubmed></ref> |- | Kinase || S6K || 2011 || 3-3 || <ref><pubmed>21976697</pubmed></ref> |- | Kinase || Focal Adhesion Kinase (FAK) || 2008, 2009 || 2, 3-1 || <ref><pubmed>17967873</pubmed></ref><ref><pubmed> 19208768</pubmed></ref> |- | Kinase || PLK1 || 2008 || 3-3 || <ref><pubmed>18615013</pubmed></ref> |- | Kinase || SAP3K || 2009 || 3-3 || <ref><pubmed>19737916</pubmed></ref> |- | Kinase || DAPK1 || 2011 || 3-1 || <ref><pubmed>21506563</pubmed></ref> |- | Phosphatase || Calcineurin || 2008, 2013 || 3-1 || <ref><pubmed>23602566</pubmed></ref><ref><pubmed> 18493642</pubmed></ref> |- | Small GTPase || Ras || 2001, 2006 || 3-2,2 || <ref><pubmed>16429133</pubmed></ref><ref><pubmed> 11429608</pubmed></ref> |- | Small GTPase || Rap || 2001 || 3-2 || <ref><pubmed>11429608</pubmed></ref> |- | Small GTPase || Rac || 2004 || 3-2 || <ref><pubmed>14570905</pubmed></ref> |- | Small GTPase || Rab5 || 2008 || 3-2 || <ref><pubmed>18385674</pubmed></ref> |- | Small GTPase || Rho || 2003, 2011 || 3-2, 2 || <ref><pubmed>21423166</pubmed></ref><ref><pubmed> 12860967</pubmed></ref> |- | Small GTPase || Cdc42 || 2004, 2011 || 3-2, 2 || <ref><pubmed>14570905</pubmed></ref><ref><pubmed> 21423166</pubmed></ref> |- | Small GTPase || Ral || 2004 || 3-3 || <ref><pubmed>15034142</pubmed></ref> |- | Small GTPase || TC10 || 2006 || 3-2 || <ref><pubmed>16950130</pubmed></ref> |- | Signal transduction || RCC1(GEF of Ran) || 2008 || 3-1 || <ref><pubmed>18762580</pubmed></ref> |- | Signal transduction || CrkII phosphorylation || 2001 || 3-1 || <ref><pubmed>11406630</pubmed></ref> |- | Signal transduction || N-WASP || 2004 || 3-1 || <ref><pubmed>15084285</pubmed></ref><ref><pubmed> 14732696</pubmed></ref> |- | Signal transduction || Adrenergic receptor || 2003 || 3-1 || <ref><pubmed>12808462</pubmed></ref> |- | Signal transduction || Parathyroid hormone receptor || 2003 || 3-1 || <ref><pubmed>12808462</pubmed></ref> |- | Signal transduction || Plasma membrane Calcium pump || 2007 || 3-1 || <ref><pubmed>17901055</pubmed></ref> |- | Acetylation || Histone acetylation || 2004, 2009 || 3-3 || <ref><pubmed>15137760</pubmed></ref><ref><pubmed> 19805290</pubmed></ref> |- | Lipid || Phosphatidylinositol (3,4,5)-trisphosphate (PIP3) || 2003 || 3-4 || <ref><pubmed>14528311</pubmed></ref> |- | Lipid || Phosphatidylinositol (4,5)-bisphosphate (PIP2) || 2008 || 3-4 || <ref><pubmed>18685081</pubmed></ref> |- | Lipid || Phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P2) || 2008 || 3-4 || <ref><pubmed>18685081</pubmed></ref> |- | Lipid || Phosphatidylinositol 4-phosphate (PI4P) || 2008 || 3-4 || <ref><pubmed>18685081</pubmed></ref> |- | Lipid || Phosphatidic acid || 2010 || 3-4 || <ref><pubmed>20826779</pubmed></ref> |- | Lipid || Diacylglycerol (DAG) || 2006, 2008 || 3-4 || <ref><pubmed>18685081</pubmed></ref><ref><pubmed> 16990811</pubmed></ref> |- | Protein interaction || Actin || 2004, 2008 || 2 || <ref><pubmed>15361876</pubmed></ref><ref><pubmed> 18512154</pubmed></ref> |- | Protein interaction || PDK1-Akt interaction || 2007 || 2 || <ref><pubmed>17407381</pubmed></ref> |- | Protein interaction || Protein tyrosine phosphatase 1B-receptor tyrosine kinases (PTP 1B-RTKs) interaction || 2002 || 2 || <ref><pubmed>11872838</pubmed></ref> |- | Protein interaction || Breast cancer resistance protein/ATP-binding cassette sub-family G member) BCRP/ABCG || 2010 || 2 || <ref><pubmed>20622991</pubmed></ref> |- | Protein interaction || Cofiin-actin interaction || 2008 || 2 || <ref><pubmed>17993279</pubmed></ref> |- | Protein interaction || PTEN-Myosin V interaction || 2009 || 2 || <ref><pubmed>19767745</pubmed></ref> |- | Protease || Caspase-3 || 1998 || 1 || <ref><pubmed>9518501</pubmed></ref> |- | Protease || Caspase-8 || 2002 || 1 || <ref><pubmed>12409609</pubmed></ref> |- | Protease || Caspase-9 || 2011 || 1 || <ref><pubmed>21637712</pubmed></ref> |- | Protease || Caspase-7 || 2006 || 1 || <ref><pubmed>17946841</pubmed></ref> |- | Protease || Matrix Metalloproteinase (MMP) || 2007, 2008 || 1 || <ref><pubmed>17187878</pubmed></ref><ref><pubmed> 18441011</pubmed></ref> |- | Protease || Protease activity (Factor Xa) || 1996 || 1 || <ref><pubmed>8707050</pubmed></ref> |- | Protease || Calpain activity || 2000 || 1 || <ref><pubmed>10688895</pubmed></ref> |- | Protease || Presenilin || 2009 || 3-1 || <ref><pubmed>19924286</pubmed></ref> |- | Other || Strain sensor || 2008 || 3-1 || <ref><pubmed>18479457</pubmed></ref> |- | Other || Membrane potential || 2001, 2008, 2012 || 3-1 || <ref><pubmed>11454036</pubmed></ref><ref><pubmed> 18622396</pubmed></ref><ref><pubmed> 22958819</pubmed></ref> |- | Other || Myosin II || 1998, 2006 || 3-1 || <ref><pubmed>9845076</pubmed></ref><ref><pubmed> 16939200</pubmed></ref> |- | Other || HIV Rev protein || 2005 || 3-1 || <ref><pubmed>16013840</pubmed></ref> |- | Other || Redox || 2010, 2011 || 3-1 || <ref><pubmed>20498274</pubmed></ref><ref><pubmed> 21606117</pubmed></ref> |- } <references />
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