Testのソースを表示

{| class="wikitable"
|+ 表1．
|-
|	分類||対象||プローブ名||年||プローブデザイン||参考文献
|-
|rowspan="21" | 生体内小分子||	[[カルシウム]]	||Cameleon||	1997	||	3-2	||	<ref><pubmed>9278050</pubmed></ref>
|-									
|[[サイクリックGMP]] ([[cGMP]])	||CGY, Cygnet, pGES-DE2, cGi||	2000, 2001, 2006	||	3-1	||	<ref><pubmed>11140757</pubmed></ref><ref><pubmed>11226257</pubmed></ref><ref><pubmed>16369548</pubmed></ref> 
|-									
|[[サイクリックAMP]] ([[cAMP]])	||Epac||	2000,2004	||	2, 3-1	||	<ref><pubmed>11872839</pubmed></ref><ref><pubmed> 15231839</pubmed></ref> 
|-									
|[[イノシトール3リン酸]] ([[IP3|IP<sub>3</sub>]])	||LIBRA, Fretino, FIRE||	2004, 2005, 2006	||	3-1	||	<ref><pubmed>15272011</pubmed></ref><ref><pubmed> 16053285</pubmed></ref><ref><pubmed> 16754959</pubmed></ref> 
|-									
|[[一酸化窒素]] ([[NO]])	||NOA-1, Piccell||	2005, 2006	||	3-1	||	<ref><pubmed>16176986</pubmed></ref><ref><pubmed> 17165805</pubmed></ref>
|-									
|[[アデノシン3リン酸]] ([[ATP]])	||A Team 1.03-nD/nA||	2012	||	3-1	||	<ref><pubmed>19720993</pubmed></ref>
|-									
|[[エストロゲン]]	||SCCoR||	2004	||	3-3	||	<ref><pubmed>15080726</pubmed></ref>
|-									
|[[アンドロゲン]]	||Ficaro||	2006	||	3-3	||	<ref><pubmed>16555356</pubmed></ref>
|-									
|[[グルココルチコイド受容体]]リガンド	||GLUCOCOR||	2007	||	3-3	||	<ref><pubmed>17897691</pubmed></ref>
|-									
|[[神経成長因子]]	||ECaus||	2008	||	3-3	||	<ref><pubmed>18510313</pubmed></ref>
|-									
|[[核内受容体]]	||conpro||	2007	||	3-2	||	<ref><pubmed>17387660</pubmed></ref>
|-									
|[[O-N-アセチルグルコサミン]] ([[O-GlcNAc]])	|| ||	2006	||	3-3	||	<ref><pubmed>17105262</pubmed></ref>
|-									
|[[ビタミンA]] ([[レチノイン酸]])	||GEPRAS||	2013	||	3-1	||	<ref><pubmed>23563268</pubmed></ref>
|-									
|[[wj:モリブデン酸|モリブデン酸]]	||MolyProbe||	2013	||	3-1	||	<ref><pubmed>23472155</pubmed></ref>
|-									
|[[グルタミン酸]]	||FLIPE||	2005	||	3-1	||	<ref><pubmed>15939876</pubmed></ref>
|-									
|[[wj:亜鉛|Zn<sup>2+</sup>]]	||eCALWY-1||	2009	||	2	||	<ref><pubmed>19718032</pubmed></ref>
|-									
|[[wj:塩素|Cl<sup>-</sup>]]	||Clomeleon||	2000	||	other	||	<ref><pubmed>11055428</pubmed></ref>
|-									
|[[wj:水素イオン濃度|水素イオン濃度]] (pH)	||GFpH, YFpH||	2001	||	other	||	<ref><pubmed>11716495</pubmed></ref>
|-									
|[[wj:グルコース|グルコース]]	||FLIPglu||	2003	||	3-1	||	<ref><pubmed>12649277</pubmed></ref>
|-									
|[[wj:マルトース|マルトース]]||FLIPmal||	2002	||	3-1	||	<ref><pubmed>12097642</pubmed></ref>
|-									
|[[wj:リボース|リボース]]||FLIPrib||	2003	||	3-1	||	<ref><pubmed>14550551</pubmed></ref>
|-									
|rowspan="26" | 	Kinase	||	[[カルシウム/カルモジュリン依存製タンパク質キナーゼII]] ([[CaMKII]])	||Camui α, green-Camui α, Camk2a reporter||	2005, 2009, 2011, 2013	||	3-1	||	<ref><pubmed>15788767</pubmed></ref><ref><pubmed> 19295602</pubmed></ref><ref><pubmed> 23602566</pubmed></ref><ref><pubmed> 21506563</pubmed></ref>
|-									
|	[[Src]]	||Srcus||	2005, 2005, 2007	||	3-3	||	<ref><pubmed>11752449</pubmed></ref><ref><pubmed> 15846350</pubmed></ref><ref><pubmed> 17284441</pubmed></ref>
|-									
|	Protein kinase C (PKC)	||CKAR, CY-PKCdelta||	2003, 2005	||	3-3, 3-1	||	<ref><pubmed>12782683</pubmed></ref><ref><pubmed> 15611119</pubmed></ref>
|-									
|	Protein kinase D (PKD)	||DKAR||	2007	||	3-3	||	<ref><pubmed>17189263</pubmed></ref>
|-									
|	Protein kinase A (PKA)	||ART, AKAR||	2000, 2001	||	3-3	||	<ref><pubmed>10700148</pubmed></ref><ref><pubmed>11752448</pubmed></ref>
|-	Table 1 A list of genetically encoded FRET probes.								
|	Abl	||Picchu||	2001	||	3-3	||	<ref><pubmed>11752449</pubmed></ref>
|-	 								
|	Bcr-Abl	||Bcr-Abl activity sensor||2010	||	3-3	||	<ref><pubmed>20817824</pubmed></ref>
|-				
|	c-Raf	||Prin-cRaf||	2005	||	3-1	||	<ref><pubmed>15711535</pubmed></ref>
|-									
|	PAK1	||Pakabi||	2009	||	3-1	||	<ref><pubmed>19574218</pubmed></ref>
|-									
|	B-raf	||Prin-Braf||	2006	||	3-1	||	<ref><pubmed>16858395</pubmed></ref>
|-									
|	ZAP-70	||ROZA||	2008	||	3-3	||	<ref><pubmed>18231606</pubmed></ref>
|-									
|	Akt	||Aktus, BKAR, Akind||	2003, 2005, 2007	||	3-3	||	<ref><pubmed>12773546</pubmed></ref><ref><pubmed> 15583002</pubmed></ref><ref><pubmed> 17407381</pubmed></ref>
|-									
|	ERK	||Miu2, Erkus, EKAR||	2006, 2007, 2008	||	3-1,3-3,3-3	||	<ref><pubmed>16418172</pubmed></ref><ref><pubmed> 17261026</pubmed></ref><ref><pubmed> 19033456</pubmed></ref>
|-									
|	Insulin receptor	||Phocus||	2002	||	3-3	||	<ref><pubmed>11875431</pubmed></ref>
|-									
|	Epidermal Growth factor receptor (EGFR) 	||	||2001	||	3-3	||	<ref><pubmed>11752449</pubmed></ref>
|-									
|	Ataxia telangiectasia mutated (ATM)	||	||	2007	||	3-3	||	<ref><pubmed>17428747</pubmed></ref>
|-									
|	Aurora B kinase	||	||	2008	||	3-3	||	<ref><pubmed>18463638</pubmed></ref>
|-									
|	Cyclin B1-CDK1	||	||	2010	||	3-3	||	<ref><pubmed>20412769</pubmed></ref>
|-									
|	Myosine light chain kinase	||MLCK-FIP	||	2002	||	3-1	||	<ref><pubmed>11815633</pubmed></ref>
|-									
|	JNK	||JNKAR1, JUNKAR1EV	||	2010, 2011	||	3-3	||	<ref><pubmed>20212108</pubmed></ref><ref name=ref21976697><pubmed> 21976697</pubmed></ref>
|-									
|	RSK	||Eevee-RSK||	2011	||	3-3	||	<ref name=ref21976697></ref>
|-									
|	S6K	||Eevee-S6K||	2011	||	3-3	||	<ref name=ref21976697></ref>
|-									
|	Focal Adhesion Kinase (FAK)	||CYFAK413, FERM-sensor||	2008, 2009	||	2, 3-1	||	<ref><pubmed>17967873</pubmed></ref><ref><pubmed> 19208768</pubmed></ref>
|-									
|	PLK1	|| ||	2008	||	3-3	||	<ref><pubmed>18615013</pubmed></ref>
|-									
|	SAP3K	|| ||	2009	||	3-3	||	<ref><pubmed>19737916</pubmed></ref>
|-									
|	DAPK1	||DAPK1(334)-F40||	2011	||	3-1	||	<ref><pubmed>21506563</pubmed></ref>
|-									
|	Phosphatase	||	Calcineurin	||CaNAR1||	2008, 2013	||	3-1	||	<ref><pubmed>23602566</pubmed></ref><ref><pubmed> 18493642</pubmed></ref>
|-									
|	Small GTPase	||	Ras	||Raichu-Ras, Fras||	2001, 2006	||	3-2,2	||	<ref><pubmed>16429133</pubmed></ref><ref name=ref11429608><pubmed> 11429608</pubmed></ref>
|-									
|	Small GTPase	||	Rap	||Raichu-Rap||	2001	||	3-2	||	<ref name=ref11429608></ref>
|-									
|	Small GTPase	||	Rac	||Raichu-Rac1||	2004	||	3-2	||	<ref><pubmed>14570905</pubmed></ref>
|-									
|	Small GTPase	||	Rab5	||Raichu-Rab5||	2008	||	3-2	||	<ref><pubmed>18385674</pubmed></ref>
|-									
|	Small GTPase	||	Rho	||Raichu-RhoA||	2003, 2011	||	3-2, 2	||	<ref><pubmed>21423166</pubmed></ref><ref><pubmed> 12860967</pubmed></ref>
|-									
|	Small GTPase	||	Cdc42	||Raichu-cdc42||	2004, 2011	||	3-2, 2	||	<ref><pubmed>14570905</pubmed></ref><ref><pubmed> 21423166</pubmed></ref>
|-									
|	Small GTPase	||	Ral	||Raichu-Ral||	2004	||	3-3	||	<ref><pubmed>15034142</pubmed></ref>
|-									
|	Small GTPase	||	TC10	||Raichu-TC10||	2006	||	3-2	||	<ref><pubmed>16950130</pubmed></ref>
|-									
|	Signal transduction	||	RCC1(GEF of Ran)	||CFP-RCC1-YFP||	2008	||	3-1	||	<ref><pubmed>18762580</pubmed></ref>
|-									
|	Signal transduction	||	CrkII phosphorylation	||Picchu||	2001	||	3-1	||	<ref><pubmed>11406630</pubmed></ref>
|-									
|	Signal transduction	||	N-WASP	||Stinger||	2004	||	3-1	||	<ref><pubmed>15084285</pubmed></ref><ref><pubmed> 14732696</pubmed></ref>
|-									
|	Signal transduction	||	Adrenergic receptor	||α<sub>2A</sub>AR-cam||	2003	||	3-1	||	<ref name=ref12808462><pubmed>12808462</pubmed></ref>
|-									
|	Signal transduction	||	Parathyroid hormone receptor	||PTHR-cam||	2003	||	3-1	||	<ref name=ref12808462></ref>
|-									
|	Signal transduction	||	Plasma membrane Calcium pump	||BFP-PMCA-GFP||	2007	||	3-1	||	<ref><pubmed>17901055</pubmed></ref>
|-									
|	Acetylation	||	Histone acetylation	||Histac||	2004, 2009	||	3-3	||	<ref><pubmed>15137760</pubmed></ref><ref><pubmed> 19805290</pubmed></ref>
|-									
|	Lipid	||	Phosphatidylinositol (3,4,5)-trisphosphate (PIP3)	||Fllip, FLIMPA||	2003	||	3-4	||	<ref><pubmed>14528311</pubmed></ref>
|-									
|	Lipid	||	Phosphatidylinositol (4,5)-bisphosphate (PIP2)	||Pippi-PI(4,5)P<sub>2</sub>||	2008	||	3-4	||	<ref name=ref18685081><pubmed>18685081</pubmed></ref>
|-									
|	Lipid	||	Phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P2) 	||Pippi-PI(3,4)P<sub>2</sub>||	2008	||	3-4	||	<ref name=ref18685081></ref>
|-									
|	 Lipid	||	Phosphatidylinositol 4-phosphate (PI4P)	||Pippi-PI(4)P||	2008	||	3-4	||	<ref name=ref18685081></ref>
|-									
|	Lipid	||	Phosphatidic acid	||Pii||	2010	||	3-4	||	<ref><pubmed>20826779</pubmed></ref>
|-									
|	Lipid	||	Diacylglycerol (DAG)	||Daglas, DIGDA||	2006, 2008	||	3-4	||	<ref><pubmed>18685081</pubmed></ref><ref><pubmed> 16990811</pubmed></ref>
|-									
|	Protein interaction	||	Actin	||	||2004, 2008	||	2	||	<ref><pubmed>15361876</pubmed></ref><ref><pubmed> 18512154</pubmed></ref>
|-									
|	Protein interaction	||	PDK1-Akt interaction	||	||2007	||	2	||	<ref><pubmed>17407381</pubmed></ref>
|-									
|	Protein interaction	||	Protein tyrosine phosphatase 1B-receptor tyrosine kinases (PTP 1B-RTKs) interaction	|| ||	2002	||	2	||	<ref><pubmed>11872838</pubmed></ref>
|-									
|	Protein interaction	||	Breast cancer resistance protein/ATP-binding cassette sub-family G member) BCRP/ABCG	||	||2010	||	2	||	<ref><pubmed>20622991</pubmed></ref>
|-									
|	Protein interaction	||	Cofiin-actin interaction	||	||2008	||	2	||	<ref><pubmed>17993279</pubmed></ref>
|-									
|	Protein interaction	||	PTEN-Myosin V interaction	||	||2009	||	2	||	<ref><pubmed>19767745</pubmed></ref>
|-									
|	Protease	||	Caspase-3	||EGFP-DEVD-EBFP||	1998	||	1	||	<ref><pubmed>9518501</pubmed></ref>
|-									
|	Protease	||	Caspase-8	||CFP-c3-YFP-c6-mRFP||	2002	||	1	||	<ref><pubmed>12409609</pubmed></ref>
|-									
|	Protease	||	Caspase-9	||SCAT9||	2011	||	1	||	<ref><pubmed>21637712</pubmed></ref>
|-									
|	Protease	||	Caspase-7	||VDEVDc||	2006	||	1	||	<ref><pubmed>17946841</pubmed></ref>
|-									
|	Protease	||	Matrix Metalloproteinase (MMP)	||YFP-MSS-CFP<sup>display</sup>, MTI-MMP-FRET biosensor||	2007, 2008	||	1	||	<ref><pubmed>17187878</pubmed></ref><ref><pubmed> 18441011</pubmed></ref> 
|-									
|	Protease	||	Protease activity (Factor Xa)	||	||1996	||	1	||	<ref><pubmed>8707050</pubmed></ref>
|-									
|	Protease	||	Calpain activity	||pYSCS||	2000	||	1	||	<ref><pubmed>10688895</pubmed></ref>
|-									
|	Protease	||	Presenilin	||GFP-PSI-RFP||	2009	||	3-1	||	<ref><pubmed>19924286</pubmed></ref>
|-									
|	Other	||	Strain sensor	||stFRET||	2008	||	3-1	||	<ref><pubmed>18479457</pubmed></ref>
|-									
|	Other	||	Membrane potential	||VSFP, Mermaid, ArcLight, VSFP-Butterfly||	2001, 2008, 2012	||	3-1	||	<ref><pubmed>11454036</pubmed></ref><ref><pubmed> 18622396</pubmed></ref><ref><pubmed> 22958819</pubmed></ref>
|-									
|	Other	||	Myosin II	||GSldCB||	1998, 2006	||	3-1	||	<ref><pubmed>9845076</pubmed></ref><ref><pubmed> 16939200</pubmed></ref>
|-									
|	Other	||	HIV Rev protein	||YRGnC-11ad||	2005	||	3-1	||	<ref><pubmed>16013840</pubmed></ref>
|-									
|	Other	||	Redox	||Redoxfluor, Gaskins||	2010, 2011	||	3-1	||	<ref><pubmed>20498274</pubmed></ref><ref><pubmed> 21606117</pubmed></ref>
|}

The numbers in the Probe Design column correspond to the section number in the “Strategies of probe design” chapter of the main text. See the webpage by Dr. Michiyuki Matsuda http://www.lif.kyoto-u.ac.jp/labs/fret/e-phogemon/unifret.htm for updated information. 				

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