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[[wj:酵素#発見|test]]
{| class="wikitable" style="float:right"
|+ 表1．
Classification ­­­Target Year Probe design References
| Small molecule || Calcium || 1997 || 3月2日 || <ref><pubmed>9278050</pubmed></ref>
|-
| Small molecule || Cyclic guanosine monophosphate (cGMP) || 2000, 2001, 2006 || 3月1日 || <ref><pubmed>11140757, 11226257, 16369548</pubmed></ref>
|-
| Small molecule || Cyclic adenosine monophosphate (cAMP) || 2000, 2004 || 2, 3-1 || <ref><pubmed>11872839, 15231839</pubmed></ref>
|-
| Small molecule || Inositol trisphosphate (IP3) || 2004, 2005, 2006 || 3月1日 || <ref><pubmed>15272011, 16053285, 16754959</pubmed></ref>
|-
| Small molecule || Nitric oxide (NO) || 2005, 2006 || 3月1日 || <ref><pubmed>16176986, 17165805</pubmed></ref>
|-
| Small molecule || Adenosine triphosphate (ATP) || 2012 || 3月1日 || <ref><pubmed>19720993</pubmed></ref>
|-
| Small molecule || Estrogen || 2004 || 3月3日 || <ref><pubmed>15080726</pubmed></ref>
|-
| Small molecule || Androgen || 2006 || 3月3日 || <ref><pubmed>16555356</pubmed></ref>
|-
| Small molecule || Glucocorticoid receptor ligands || 2007 || 3月3日 || <ref><pubmed>17897691</pubmed></ref>
|-
| Small molecule || Neurotrophic factor || 2008 || 3月3日 || <ref><pubmed>18510313</pubmed></ref>
|-
| Small molecule || Nuclear receptor || 2007 || 3月2日 || <ref><pubmed>17387660</pubmed></ref>
|-
| Small molecule || O-N-acetylglucosamine (O-GlcNAc) || 2006 || 3月3日 || <ref><pubmed>17105262</pubmed></ref>
|-
| Small molecule || Vitamin A (Retinoic acid) || 2013 || 3月1日 || <ref><pubmed>23563268</pubmed></ref>
|-
| Small molecule || Molybdate || 2013 || 3月1日 || <ref><pubmed>23472155</pubmed></ref>
|-
| Small molecule || Glutamate || 2005 || 3月1日 || <ref><pubmed>15939876</pubmed></ref>
|-
| Small molecule || Zn2+ || 2009 || 2 || <ref><pubmed>19718032</pubmed></ref>
|-
| Small molecule || Cl- || 2000 || other || <ref><pubmed>11055428</pubmed></ref>
|-
| Small molecule || pH || 2001 || other || <ref><pubmed>11716495</pubmed></ref>
|-
| Small molecule || Glucose || 2003 || 3月1日 || <ref><pubmed>12649277</pubmed></ref>
|-
| Small molecule || Maltose || 2002 || 3月1日 || <ref><pubmed>12097642</pubmed></ref>
|-
| Small molecule || Ribose || 2003 || 3月1日 || <ref><pubmed>14550551</pubmed></ref>
|-
| Kinase || Calcium/Calmodulin-dependent protein kinase II (CaMKII) || 2005, 2009, 2011, 2013 || 3月1日 || <ref><pubmed>15788767, 19295602, 23602566, 21506563</pubmed></ref>
|-
| Kinase || Src || 2005, 2005, 2007 || 3月3日 || <ref><pubmed>11752449, 15846350, 17284441</pubmed></ref>
|-
| Kinase || Protein kinase C (PKC) || 2003, 2005 || 3-3, 3-1 || <ref><pubmed>12782683, 15611119</pubmed></ref>
|-
| Kinase || Protein kinase D (PKD) || 2007 || 3月3日 || <ref><pubmed>17189263</pubmed></ref>
|-
| Kinase || Protein kinase A (PKA) || 2000, 2001 || 3月3日 || <ref><pubmed>10700148, 11752448</pubmed></ref>
|- Table 1 A list of genetically encoded FRET probes.
| Kinase || Abl || 2001 || 3月3日 || <ref><pubmed>11752449</pubmed></ref>
|-
| Kinase || Bcr-Abl || 2010 || 3月3日 || <ref><pubmed>20817824</pubmed></ref>
|- The numbers in the Probe Design column correspond to the section number in the “Strategies of probe design” chapter of the main text. See the webpage by Dr. Michiyuki Matsuda http://www.lif.kyoto-u.ac.jp/labs/fret/e-phogemon/unifret.htm for updated information.
| Kinase || c-Raf || 2005 || 3月1日 || <ref><pubmed>15711535</pubmed></ref>
|-
| Kinase || PAK1 || 2009 || 3月1日 || <ref><pubmed>19574218</pubmed></ref>
|-
| Kinase || B-raf || 2006 || 3月1日 || <ref><pubmed>16858395</pubmed></ref>
|-
| Kinase || ZAP-70 || 2008 || 3月3日 || <ref><pubmed>18231606</pubmed></ref>
|-
| Kinase || Akt || 2003, 2005, 2007 || 3月3日 || <ref><pubmed>12773546, 15583002, 17407381</pubmed></ref>
|-
| Kinase || ERK || 2006, 2007, 2008 || 3-1,3-3,3-3 || <ref><pubmed>16418172, 17261026, 19033456</pubmed></ref>
|-
| Kinase || Insulin receptor || 2002 || 3月3日 || <ref><pubmed>11875431</pubmed></ref>
|-
| Kinase || Epidermal Growth factor receptor (EGFR) || 2001 || 3月3日 || <ref><pubmed>11752449</pubmed></ref>
|-
| Kinase || Ataxia telangiectasia mutated (ATM) || 2007 || 3月3日 || <ref><pubmed>17428747</pubmed></ref>
|-
| Kinase || Aurora B kinase || 2008 || 3月3日 || <ref><pubmed>18463638</pubmed></ref>
|-
| Kinase || Cyclin B1-CDK1 || 2010 || 3月3日 || <ref><pubmed>20412769</pubmed></ref>
|-
| Kinase || Myosine light chain kinase || 2002 || 3月1日 || <ref><pubmed>11815633</pubmed></ref>
|-
| Kinase || JNK || 2010, 2011 || 3月3日 || <ref><pubmed>20212108, 21976697</pubmed></ref>
|-
| Kinase || RSK || 2011 || 3月3日 || <ref><pubmed>21976697</pubmed></ref>
|-
| Kinase || S6K || 2011 || 3月3日 || <ref><pubmed>21976697</pubmed></ref>
|-
| Kinase || Focal Adhesion Kinase (FAK) || 2008, 2009 || 2, 3-1 || <ref><pubmed>17967873, 19208768</pubmed></ref>
|-
| Kinase || PLK1 || 2008 || 3月3日 || <ref><pubmed>18615013</pubmed></ref>
|-
| Kinase || SAP3K || 2009 || 3月3日 || <ref><pubmed>19737916</pubmed></ref>
|-
| Kinase || DAPK1 || 2011 || 3月1日 || <ref><pubmed>21506563</pubmed></ref>
|-
| Phosphatase || Calcineurin || 2008, 2013 || 3月1日 || <ref><pubmed>23602566, 18493642</pubmed></ref>
|-
| Small GTPase || Ras || 2001, 2006 || 3-2,2 || <ref><pubmed>16429133, 11429608</pubmed></ref>
|-
| Small GTPase || Rap || 2001 || 3月2日 || <ref><pubmed>11429608</pubmed></ref>
|-
| Small GTPase || Rac || 2004 || 3月2日 || <ref><pubmed>14570905</pubmed></ref>
|-
| Small GTPase || Rab5 || 2008 || 3月2日 || <ref><pubmed>18385674</pubmed></ref>
|-
| Small GTPase || Rho || 2003, 2011 || 3-2, 2 || <ref><pubmed>21423166, 12860967</pubmed></ref>
|-
| Small GTPase || Cdc42 || 2004, 2011 || 3-2, 2 || <ref><pubmed>14570905, 21423166</pubmed></ref>
|-
| Small GTPase || Ral || 2004 || 3月3日 || <ref><pubmed>15034142</pubmed></ref>
|-
| Small GTPase || TC10 || 2006 || 3月2日 || <ref><pubmed>16950130</pubmed></ref>
|-
| Signal transduction || RCC1(GEF of Ran) || 2008 || 3月1日 || <ref><pubmed>18762580</pubmed></ref>
|-
| Signal transduction || CrkII phosphorylation || 2001 || 3月1日 || <ref><pubmed>11406630</pubmed></ref>
|-
| Signal transduction || N-WASP || 2004 || 3月1日 || <ref><pubmed>15084285, 14732696</pubmed></ref>
|-
| Signal transduction || Adrenergic receptor || 2003 || 3月1日 || <ref><pubmed>12808462</pubmed></ref>
|-
| Signal transduction || Parathyroid hormone receptor || 2003 || 3月1日 || <ref><pubmed>12808462</pubmed></ref>
|-
| Signal transduction || Plasma membrane Calcium pump || 2007 || 3月1日 || <ref><pubmed>17901055</pubmed></ref>
|-
| Acetylation || Histone acetylation || 2004, 2009 || 3月3日 || <ref><pubmed>15137760, 19805290</pubmed></ref>
|-
| Lipid || Phosphatidylinositol (3,4,5)-trisphosphate (PIP3) || 2003 || 3月4日 || <ref><pubmed>14528311</pubmed></ref>
|-
| Lipid || Phosphatidylinositol (4,5)-bisphosphate (PIP2) || 2008 || 3月4日 || <ref><pubmed>18685081</pubmed></ref>
|-
| Lipid || Phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P2) || 2008 || 3月4日 || <ref><pubmed>18685081</pubmed></ref>
|-
| Lipid || Phosphatidylinositol 4-phosphate (PI4P) || 2008 || 3月4日 || <ref><pubmed>18685081</pubmed></ref>
|-
| Lipid || Phosphatidic acid || 2010 || 3月4日 || <ref><pubmed>20826779</pubmed></ref>
|-
| Lipid || Diacylglycerol (DAG) || 2006, 2008 || 3月4日 || <ref><pubmed>18685081, 16990811</pubmed></ref>
|-
| Protein interaction || Actin || 2004, 2008 || 2 || <ref><pubmed>15361876, 18512154</pubmed></ref>
|-
| Protein interaction || PDK1-Akt interaction || 2007 || 2 || <ref><pubmed>17407381</pubmed></ref>
|-
| Protein interaction || Protein tyrosine phosphatase 1B-receptor tyrosine kinases (PTP 1B-RTKs) interaction || 2002 || 2 || <ref><pubmed>11872838</pubmed></ref>
|-
| Protein interaction || Breast cancer resistance protein/ATP-binding cassette sub-family G member) BCRP/ABCG || 2010 || 2 || <ref><pubmed>20622991</pubmed></ref>
|-
| Protein interaction || Cofiin-actin interaction || 2008 || 2 || <ref><pubmed>17993279</pubmed></ref>
|-
| Protein interaction || PTEN-Myosin V interaction || 2009 || 2 || <ref><pubmed>19767745</pubmed></ref>
|-
| Protease || Caspase-3 || 1998 || 1 || <ref><pubmed>9518501</pubmed></ref>
|-
| Protease || Caspase-8 || 2002 || 1 || <ref><pubmed>12409609</pubmed></ref>
|-
| Protease || Caspase-9 || 2011 || 1 || <ref><pubmed>21637712</pubmed></ref>
|-
| Protease || Caspase-7 || 2006 || 1 || <ref><pubmed>17946841</pubmed></ref>
|-
| Protease || Matrix Metalloproteinase (MMP) || 2007, 2008 || 1 || <ref><pubmed>17187878, 18441011</pubmed></ref>
|-
| Protease || Protease activity (Factor Xa) || 1996 || 1 || <ref><pubmed>8707050</pubmed></ref>
|-
| Protease || Calpain activity || 2000 || 1 || <ref><pubmed>10688895</pubmed></ref>
|-
| Protease || Presenilin || 2009 || 3月1日 || <ref><pubmed>19924286</pubmed></ref>
|-
| Other || Strain sensor || 2008 || 3月1日 || <ref><pubmed>18479457</pubmed></ref>
|-
| Other || Membrane potential || 2001, 2008, 2012 || 3月1日 || <ref><pubmed>11454036, 18622396, 22958819</pubmed></ref>
|-
| Other || Myosin II || 1998, 2006 || 3月1日 || <ref><pubmed>9845076, 16939200</pubmed></ref>
|-
| Other || HIV Rev protein || 2005 || 3月1日 || <ref><pubmed>16013840</pubmed></ref>
|-
| Other || Redox || 2010, 2011 || 3月1日 || <ref><pubmed>20498274, 21606117</pubmed></ref>
|-
}


== PDBHandler Test ==
<references />
<nowiki>[[</nowiki>File:2A07.pdb]]
 
[[File:2A07.pdb]]
 
<nowiki>[[</nowiki>File:1BL8.pdb|200px|thumb|right|1BL8]]
[[File:1BL8.pdb|200px|thumb|right|1BL8]]
 
<nowiki><gallery></nowiki>
File:2A07.pdb|PDB Id: 2A07
File:1BL8.pdb|PDB Id: 1BL8
File:1RUZ.pdb|PDB Id: 1RUZ
File:7ICG.pdb|PDB Id: 7ICG
<nowiki></gallery></nowiki>
 
<gallery>
File:2A07.pdb|PDB Id: 2A07
File:1BL8.pdb|PDB Id: 1BL8
File:1RUZ.pdb|PDB Id: 1RUZ
File:7ICG.pdb|PDB Id: 7ICG
</gallery>

2013年10月3日 (木) 10:16時点における版

}
  1. ↑ Miyawaki, A., Llopis, J., Heim, R., McCaffery, J.M., Adams, J.A., Ikura, M., & Tsien, R.Y. (1997).
    Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin. Nature, 388(6645), 882-7. [PubMed:9278050] [WorldCat] [DOI]
  2. ↑ Sato, M., Hida, N., Ozawa, T., & Umezawa, Y. (2000).
    Fluorescent indicators for cyclic GMP based on cyclic GMP-dependent protein kinase Ialpha and green fluorescent proteins. Analytical chemistry, 72(24), 5918-24. [PubMed:11140757] [WorldCat] [DOI]
    Honda, A., Adams, S.R., Sawyer, C.L., Lev-Ram, V., Tsien, R.Y., & Dostmann, W.R. (2001).
    Spatiotemporal dynamics of guanosine 3',5'-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator. Proceedings of the National Academy of Sciences of the United States of America, 98(5), 2437-42. [PubMed:11226257] [PMC] [WorldCat] [DOI]
    Nikolaev, V.O., Gambaryan, S., & Lohse, M.J. (2006).
    Fluorescent sensors for rapid monitoring of intracellular cGMP. Nature methods, 3(1), 23-5. [PubMed:16369548] [WorldCat] [DOI]
  3. ↑ Zaccolo, M., & Pozzan, T. (2002).
    Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science (New York, N.Y.), 295(5560), 1711-5. [PubMed:11872839] [WorldCat] [DOI]
    Nikolaev, V.O., Bünemann, M., Hein, L., Hannawacker, A., & Lohse, M.J. (2004).
    Novel single chain cAMP sensors for receptor-induced signal propagation. The Journal of biological chemistry, 279(36), 37215-8. [PubMed:15231839] [WorldCat] [DOI]
  4. ↑ Tanimura, A., Nezu, A., Morita, T., Turner, R.J., & Tojyo, Y. (2004).
    Fluorescent biosensor for quantitative real-time measurements of inositol 1,4,5-trisphosphate in single living cells. The Journal of biological chemistry, 279(37), 38095-8. [PubMed:15272011] [WorldCat] [DOI]
    Sato, M., Ueda, Y., Shibuya, M., & Umezawa, Y. (2005).
    Locating inositol 1,4,5-trisphosphate in the nucleus and neuronal dendrites with genetically encoded fluorescent indicators. Analytical chemistry, 77(15), 4751-8. [PubMed:16053285] [WorldCat] [DOI]
    Matsu-ura, T., Michikawa, T., Inoue, T., Miyawaki, A., Yoshida, M., & Mikoshiba, K. (2006).
    Cytosolic inositol 1,4,5-trisphosphate dynamics during intracellular calcium oscillations in living cells. The Journal of cell biology, 173(5), 755-65. [PubMed:16754959] [PMC] [WorldCat] [DOI]
  5. ↑ Sato, M., Hida, N., & Umezawa, Y. (2005).
    Imaging the nanomolar range of nitric oxide with an amplifier-coupled fluorescent indicator in living cells. Proceedings of the National Academy of Sciences of the United States of America, 102(41), 14515-20. [PubMed:16176986] [PMC] [WorldCat] [DOI]
    Sato, M., Nakajima, T., Goto, M., & Umezawa, Y. (2006).
    Cell-based indicator to visualize picomolar dynamics of nitric oxide release from living cells. Analytical chemistry, 78(24), 8175-82. [PubMed:17165805] [WorldCat] [DOI]
  6. ↑ Imamura, H., Nhat, K.P., Togawa, H., Saito, K., Iino, R., Kato-Yamada, Y., ..., & Noji, H. (2009).
    Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators. Proceedings of the National Academy of Sciences of the United States of America, 106(37), 15651-6. [PubMed:19720993] [PMC] [WorldCat] [DOI]
  7. ↑ Awais, M., Sato, M., Sasaki, K., & Umezawa, Y. (2004).
    A genetically encoded fluorescent indicator capable of discriminating estrogen agonists from antagonists in living cells. Analytical chemistry, 76(8), 2181-6. [PubMed:15080726] [WorldCat] [DOI]
  8. ↑ Awais, M., Sato, M., Lee, X., & Umezawa, Y. (2006).
    A fluorescent indicator to visualize activities of the androgen receptor ligands in single living cells. Angewandte Chemie (International ed. in English), 45(17), 2707-12. [PubMed:16555356] [WorldCat] [DOI]
  9. ↑ Awais, M., Sato, M., & Umezawa, Y. (2007).
    Optical probes to identify the glucocorticoid receptor ligands in living cells. Steroids, 72(14), 949-54. [PubMed:17897691] [WorldCat] [DOI]
  10. ↑ Nakajima, T., Sato, M., Akaza, N., & Umezawa, Y. (2008).
    Cell-based fluorescent indicator to visualize brain-derived neurotrophic factor secreted from living neurons. ACS chemical biology, 3(6), 352-8. [PubMed:18510313] [WorldCat] [DOI]
  11. ↑ Awais, M., Sato, M., & Umezawa, Y. (2007).
    Imaging of selective nuclear receptor modulator-induced conformational changes in the nuclear receptor to allow interaction with coactivator and corepressor proteins in living cells. Chembiochem : a European journal of chemical biology, 8(7), 737-43. [PubMed:17387660] [WorldCat] [DOI]
  12. ↑ Carrillo, L.D., Krishnamoorthy, L., & Mahal, L.K. (2006).
    A cellular FRET-based sensor for beta-O-GlcNAc, a dynamic carbohydrate modification involved in signaling. Journal of the American Chemical Society, 128(46), 14768-9. [PubMed:17105262] [WorldCat] [DOI]
  13. ↑ Shimozono, S., Iimura, T., Kitaguchi, T., Higashijima, S., & Miyawaki, A. (2013).
    Visualization of an endogenous retinoic acid gradient across embryonic development. Nature, 496(7445), 363-6. [PubMed:23563268] [WorldCat] [DOI]
  14. ↑ Nakanishi, Y., Iida, S., Ueoka-Nakanishi, H., Niimi, T., Tomioka, R., & Maeshima, M. (2013).
    Exploring dynamics of molybdate in living animal cells by a genetically encoded FRET nanosensor. PloS one, 8(3), e58175. [PubMed:23472155] [PMC] [WorldCat] [DOI]
  15. ↑ Okumoto, S., Looger, L.L., Micheva, K.D., Reimer, R.J., Smith, S.J., & Frommer, W.B. (2005).
    Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors. Proceedings of the National Academy of Sciences of the United States of America, 102(24), 8740-5. [PubMed:15939876] [PMC] [WorldCat] [DOI]
  16. ↑ Vinkenborg, J.L., Nicolson, T.J., Bellomo, E.A., Koay, M.S., Rutter, G.A., & Merkx, M. (2009).
    Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis. Nature methods, 6(10), 737-40. [PubMed:19718032] [PMC] [WorldCat] [DOI]
  17. ↑ Kuner, T., & Augustine, G.J. (2000).
    A genetically encoded ratiometric indicator for chloride: capturing chloride transients in cultured hippocampal neurons. Neuron, 27(3), 447-59. [PubMed:11055428] [WorldCat] [DOI]
  18. ↑ Awaji, T., Hirasawa, A., Shirakawa, H., Tsujimoto, G., & Miyazaki, S. (2001).
    Novel green fluorescent protein-based ratiometric indicators for monitoring pH in defined intracellular microdomains. Biochemical and biophysical research communications, 289(2), 457-62. [PubMed:11716495] [WorldCat] [DOI]
  19. ↑ Fehr, M., Lalonde, S., Lager, I., Wolff, M.W., & Frommer, W.B. (2003).
    In vivo imaging of the dynamics of glucose uptake in the cytosol of COS-7 cells by fluorescent nanosensors. The Journal of biological chemistry, 278(21), 19127-33. [PubMed:12649277] [WorldCat] [DOI]
  20. ↑ Fehr, M., Frommer, W.B., & Lalonde, S. (2002).
    Visualization of maltose uptake in living yeast cells by fluorescent nanosensors. Proceedings of the National Academy of Sciences of the United States of America, 99(15), 9846-51. [PubMed:12097642] [PMC] [WorldCat] [DOI]
  21. ↑ Lager, I., Fehr, M., Frommer, W.B., & Lalonde, S. (2003).
    Development of a fluorescent nanosensor for ribose. FEBS letters, 553(1-2), 85-9. [PubMed:14550551] [WorldCat] [DOI]
  22. ↑ Takao, K., Okamoto, K., Nakagawa, T., Neve, R.L., Nagai, T., Miyawaki, A., ..., & Hayashi, Y. (2005).
    Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(12), 3107-12. [PubMed:15788767] [PMC] [WorldCat] [DOI]
    Lee, S.J., Escobedo-Lozoya, Y., Szatmari, E.M., & Yasuda, R. (2009).
    Activation of CaMKII in single dendritic spines during long-term potentiation. Nature, 458(7236), 299-304. [PubMed:19295602] [PMC] [WorldCat] [DOI]
    Fujii, H., Inoue, M., Okuno, H., Sano, Y., Takemoto-Kimura, S., Kitamura, K., ..., & Bito, H. (2013).
    Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. Cell reports, 3(4), 978-87. [PubMed:23602566] [WorldCat] [DOI]
    Piljić, A., de Diego, I., Wilmanns, M., & Schultz, C. (2011).
    Rapid development of genetically encoded FRET reporters. ACS chemical biology, 6(7), 685-91. [PubMed:21506563] [WorldCat] [DOI]
  23. ↑ Ting, A.Y., Kain, K.H., Klemke, R.L., & Tsien, R.Y. (2001).
    Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proceedings of the National Academy of Sciences of the United States of America, 98(26), 15003-8. [PubMed:11752449] [PMC] [WorldCat] [DOI]
    Wang, Y., Botvinick, E.L., Zhao, Y., Berns, M.W., Usami, S., Tsien, R.Y., & Chien, S. (2005).
    Visualizing the mechanical activation of Src. Nature, 434(7036), 1040-5. [PubMed:15846350] [WorldCat] [DOI]
    Hitosugi, T., Sasaki, K., Sato, M., Suzuki, Y., & Umezawa, Y. (2007).
    Epidermal growth factor directs sex-specific steroid signaling through Src activation. The Journal of biological chemistry, 282(14), 10697-706. [PubMed:17284441] [WorldCat] [DOI]
  24. ↑ Violin, J.D., Zhang, J., Tsien, R.Y., & Newton, A.C. (2003).
    A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. The Journal of cell biology, 161(5), 899-909. [PubMed:12782683] [PMC] [WorldCat] [DOI]
    Braun, D.C., Garfield, S.H., & Blumberg, P.M. (2005).
    Analysis by fluorescence resonance energy transfer of the interaction between ligands and protein kinase Cdelta in the intact cell. The Journal of biological chemistry, 280(9), 8164-71. [PubMed:15611119] [WorldCat] [DOI]
  25. ↑ Kunkel, M.T., Toker, A., Tsien, R.Y., & Newton, A.C. (2007).
    Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. The Journal of biological chemistry, 282(9), 6733-42. [PubMed:17189263] [PMC] [WorldCat] [DOI]
  26. ↑ Nagai, Y., Miyazaki, M., Aoki, R., Zama, T., Inouye, S., Hirose, K., ..., & Hagiwara, M. (2000).
    A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo. Nature biotechnology, 18(3), 313-6. [PubMed:10700148] [WorldCat] [DOI]
    Zhang, J., Ma, Y., Taylor, S.S., & Tsien, R.Y. (2001).
    Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proceedings of the National Academy of Sciences of the United States of America, 98(26), 14997-5002. [PubMed:11752448] [PMC] [WorldCat] [DOI]
  27. ↑ Ting, A.Y., Kain, K.H., Klemke, R.L., & Tsien, R.Y. (2001).
    Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proceedings of the National Academy of Sciences of the United States of America, 98(26), 15003-8. [PubMed:11752449] [PMC] [WorldCat] [DOI]
  28. ↑ Tunceroglu, A., Matsuda, M., & Birge, R.B. (2010).
    Real-time fluorescent resonance energy transfer analysis to monitor drug resistance in chronic myelogenous leukemia. Molecular cancer therapeutics, 9(11), 3065-73. [PubMed:20817824] [PMC] [WorldCat] [DOI]
  29. ↑ Terai, K., & Matsuda, M. (2005).
    Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase. EMBO reports, 6(3), 251-5. [PubMed:15711535] [PMC] [WorldCat] [DOI]
  30. ↑ Parrini, M.C., Camonis, J., Matsuda, M., & de Gunzburg, J. (2009).
    Dissecting activation of the PAK1 kinase at protrusions in living cells. The Journal of biological chemistry, 284(36), 24133-43. [PubMed:19574218] [PMC] [WorldCat] [DOI]
  31. ↑ Terai, K., & Matsuda, M. (2006).
    The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf. The EMBO journal, 25(15), 3556-64. [PubMed:16858395] [PMC] [WorldCat] [DOI]
  32. ↑ Randriamampita, C., Mouchacca, P., Malissen, B., Marguet, D., Trautmann, A., & Lellouch, A.C. (2008).
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表1． Classification ­­­Target Year Probe design References
Small molecule Calcium 1997 3月2日 [1]
Small molecule Cyclic guanosine monophosphate (cGMP) 2000, 2001, 2006 3月1日 [2]
Small molecule Cyclic adenosine monophosphate (cAMP) 2000, 2004 2, 3-1 [3]
Small molecule Inositol trisphosphate (IP3) 2004, 2005, 2006 3月1日 [4]
Small molecule Nitric oxide (NO) 2005, 2006 3月1日 [5]
Small molecule Adenosine triphosphate (ATP) 2012 3月1日 [6]
Small molecule Estrogen 2004 3月3日 [7]
Small molecule Androgen 2006 3月3日 [8]
Small molecule Glucocorticoid receptor ligands 2007 3月3日 [9]
Small molecule Neurotrophic factor 2008 3月3日 [10]
Small molecule Nuclear receptor 2007 3月2日 [11]
Small molecule O-N-acetylglucosamine (O-GlcNAc) 2006 3月3日 [12]
Small molecule Vitamin A (Retinoic acid) 2013 3月1日 [13]
Small molecule Molybdate 2013 3月1日 [14]
Small molecule Glutamate 2005 3月1日 [15]
Small molecule Zn2+ 2009 2 [16]
Small molecule Cl- 2000 other [17]
Small molecule pH 2001 other [18]
Small molecule Glucose 2003 3月1日 [19]
Small molecule Maltose 2002 3月1日 [20]
Small molecule Ribose 2003 3月1日 [21]
Kinase Calcium/Calmodulin-dependent protein kinase II (CaMKII) 2005, 2009, 2011, 2013 3月1日 [22]
Kinase Src 2005, 2005, 2007 3月3日 [23]
Kinase Protein kinase C (PKC) 2003, 2005 3-3, 3-1 [24]
Kinase Protein kinase D (PKD) 2007 3月3日 [25]
Kinase Protein kinase A (PKA) 2000, 2001 3月3日 [26]
Kinase Abl 2001 3月3日 [27]
Kinase Bcr-Abl 2010 3月3日 [28]
Kinase c-Raf 2005 3月1日 [29]
Kinase PAK1 2009 3月1日 [30]
Kinase B-raf 2006 3月1日 [31]
Kinase ZAP-70 2008 3月3日 [32]
Kinase Akt 2003, 2005, 2007 3月3日 [33]
Kinase ERK 2006, 2007, 2008 3-1,3-3,3-3 [34]
Kinase Insulin receptor 2002 3月3日 [35]
Kinase Epidermal Growth factor receptor (EGFR) 2001 3月3日 [36]
Kinase Ataxia telangiectasia mutated (ATM) 2007 3月3日 [37]
Kinase Aurora B kinase 2008 3月3日 [38]
Kinase Cyclin B1-CDK1 2010 3月3日 [39]
Kinase Myosine light chain kinase 2002 3月1日 [40]
Kinase JNK 2010, 2011 3月3日 [41]
Kinase RSK 2011 3月3日 [42]
Kinase S6K 2011 3月3日 [43]
Kinase Focal Adhesion Kinase (FAK) 2008, 2009 2, 3-1 [44]
Kinase PLK1 2008 3月3日 [45]
Kinase SAP3K 2009 3月3日 [46]
Kinase DAPK1 2011 3月1日 [47]
Phosphatase Calcineurin 2008, 2013 3月1日 [48]
Small GTPase Ras 2001, 2006 3-2,2 [49]
Small GTPase Rap 2001 3月2日 [50]
Small GTPase Rac 2004 3月2日 [51]
Small GTPase Rab5 2008 3月2日 [52]
Small GTPase Rho 2003, 2011 3-2, 2 [53]
Small GTPase Cdc42 2004, 2011 3-2, 2 [54]
Small GTPase Ral 2004 3月3日 [55]
Small GTPase TC10 2006 3月2日 [56]
Signal transduction RCC1(GEF of Ran) 2008 3月1日 [57]
Signal transduction CrkII phosphorylation 2001 3月1日 [58]
Signal transduction N-WASP 2004 3月1日 [59]
Signal transduction Adrenergic receptor 2003 3月1日 [60]
Signal transduction Parathyroid hormone receptor 2003 3月1日 [61]
Signal transduction Plasma membrane Calcium pump 2007 3月1日 [62]
Acetylation Histone acetylation 2004, 2009 3月3日 [63]
Lipid Phosphatidylinositol (3,4,5)-trisphosphate (PIP3) 2003 3月4日 [64]
Lipid Phosphatidylinositol (4,5)-bisphosphate (PIP2) 2008 3月4日 [65]
Lipid Phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P2) 2008 3月4日 [66]
Lipid Phosphatidylinositol 4-phosphate (PI4P) 2008 3月4日 [67]
Lipid Phosphatidic acid 2010 3月4日 [68]
Lipid Diacylglycerol (DAG) 2006, 2008 3月4日 [69]
Protein interaction Actin 2004, 2008 2 [70]
Protein interaction PDK1-Akt interaction 2007 2 [71]
Protein interaction Protein tyrosine phosphatase 1B-receptor tyrosine kinases (PTP 1B-RTKs) interaction 2002 2 [72]
Protein interaction Breast cancer resistance protein/ATP-binding cassette sub-family G member) BCRP/ABCG 2010 2 [73]
Protein interaction Cofiin-actin interaction 2008 2 [74]
Protein interaction PTEN-Myosin V interaction 2009 2 [75]
Protease Caspase-3 1998 1 [76]
Protease Caspase-8 2002 1 [77]
Protease Caspase-9 2011 1 [78]
Protease Caspase-7 2006 1 [79]
Protease Matrix Metalloproteinase (MMP) 2007, 2008 1 [80]
Protease Protease activity (Factor Xa) 1996 1 [81]
Protease Calpain activity 2000 1 [82]
Protease Presenilin 2009 3月1日 [83]
Other Strain sensor 2008 3月1日 [84]
Other Membrane potential 2001, 2008, 2012 3月1日 [85]
Other Myosin II 1998, 2006 3月1日 [86]
Other HIV Rev protein 2005 3月1日 [87]
Other Redox 2010, 2011 3月1日 [88]
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