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2013年10月4日 (金) 09:30時点における版

493 バイト追加 、 2013年10月4日 (金)
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{| class="wikitable" style="float:right"
{| class="wikitable"
|+ 表1．
|+ 表1．
Classification ­­­Target Year Probe design References
|-
| Small molecule || Calcium || 1997 || 3月2日 || <ref><pubmed>9278050</pubmed></ref>
| Classification||Target ||Year||Probe design ||References
|-
| Small molecule || Calcium || 1997 || 3-2 || <ref><pubmed>9278050</pubmed></ref>
|-
|-
| Small molecule || Cyclic guanosine monophosphate (cGMP) || 2000, 2001, 2006 || 3月1日 || <ref><pubmed>11140757, 11226257, 16369548</pubmed></ref>  
| Small molecule || Cyclic guanosine monophosphate (cGMP) || 2000, 2001, 2006 || 3-1 || <ref><pubmed>111407578</pubmed></ref><ref><pubmed>11226257</pubmed></ref><ref><pubmed>16369548</pubmed></ref>  
|-
|-
| Small molecule || Cyclic adenosine monophosphate (cAMP) || 2000, 2004 || 2, 3-1 || <ref><pubmed>11872839, 15231839</pubmed></ref>  
| Small molecule || Cyclic adenosine monophosphate (cAMP) || 2000,2004 || 2, 3-1 || <ref><pubmed>11872839</pubmed></ref><ref><pubmed> 15231839</pubmed></ref>  
|-
|-
| Small molecule || Inositol trisphosphate (IP3) || 2004, 2005, 2006 || 3月1日 || <ref><pubmed>15272011, 16053285, 16754959</pubmed></ref>  
| Small molecule || Inositol trisphosphate (IP3) || 2004, 2005, 2006 || 3-1 || <ref><pubmed>15272011</pubmed></ref><ref><pubmed> 16053285</pubmed></ref><ref><pubmed> 16754959</pubmed></ref>  
|-
|-
| Small molecule || Nitric oxide (NO) || 2005, 2006 || 3月1日 || <ref><pubmed>16176986, 17165805</pubmed></ref>
| Small molecule || Nitric oxide (NO) || 2005, 2006 || 3-1 || <ref><pubmed>16176986</pubmed></ref><ref><pubmed> 17165805</pubmed></ref>
|-
|-
| Small molecule || Adenosine triphosphate (ATP) || 2012 || 3月1日 || <ref><pubmed>19720993</pubmed></ref>
| Small molecule || Adenosine triphosphate (ATP) || 2012 || 3-1 || <ref><pubmed>19720993</pubmed></ref>
|-
|-
| Small molecule || Estrogen || 2004 || 3月3日 || <ref><pubmed>15080726</pubmed></ref>
| Small molecule || Estrogen || 2004 || 3-3 || <ref><pubmed>15080726</pubmed></ref>
|-
|-
| Small molecule || Androgen || 2006 || 3月3日 || <ref><pubmed>16555356</pubmed></ref>
| Small molecule || Androgen || 2006 || 3-3 || <ref><pubmed>16555356</pubmed></ref>
|-
|-
| Small molecule || Glucocorticoid receptor ligands || 2007 || 3月3日 || <ref><pubmed>17897691</pubmed></ref>
| Small molecule || Glucocorticoid receptor ligands || 2007 || 3-3 || <ref><pubmed>17897691</pubmed></ref>
|-
|-
| Small molecule || Neurotrophic factor || 2008 || 3月3日 || <ref><pubmed>18510313</pubmed></ref>
| Small molecule || Neurotrophic factor || 2008 || 3-3 || <ref><pubmed>18510313</pubmed></ref>
|-
|-
| Small molecule || Nuclear receptor || 2007 || 3月2日 || <ref><pubmed>17387660</pubmed></ref>
| Small molecule || Nuclear receptor || 2007 || 3-2 || <ref><pubmed>17387660</pubmed></ref>
|-
|-
| Small molecule || O-N-acetylglucosamine (O-GlcNAc) || 2006 || 3月3日 || <ref><pubmed>17105262</pubmed></ref>
| Small molecule || O-N-acetylglucosamine (O-GlcNAc) || 2006 || 3-3 || <ref><pubmed>17105262</pubmed></ref>
|-
|-
| Small molecule || Vitamin A (Retinoic acid) || 2013 || 3月1日 || <ref><pubmed>23563268</pubmed></ref>
| Small molecule || Vitamin A (Retinoic acid) || 2013 || 3-1 || <ref><pubmed>23563268</pubmed></ref>
|-
|-
| Small molecule || Molybdate || 2013 || 3月1日 || <ref><pubmed>23472155</pubmed></ref>
| Small molecule || Molybdate || 2013 || 3-1 || <ref><pubmed>23472155</pubmed></ref>
|-
|-
| Small molecule || Glutamate || 2005 || 3月1日 || <ref><pubmed>15939876</pubmed></ref>
| Small molecule || Glutamate || 2005 || 3-1 || <ref><pubmed>15939876</pubmed></ref>
|-
|-
| Small molecule || Zn2+ || 2009 || 2 || <ref><pubmed>19718032</pubmed></ref>
| Small molecule || Zn2+ || 2009 || 2 || <ref><pubmed>19718032</pubmed></ref>
38行目: 40行目:
| Small molecule || pH || 2001 || other || <ref><pubmed>11716495</pubmed></ref>
| Small molecule || pH || 2001 || other || <ref><pubmed>11716495</pubmed></ref>
|-
|-
| Small molecule || Glucose || 2003 || 3月1日 || <ref><pubmed>12649277</pubmed></ref>
| Small molecule || Glucose || 2003 || 3-1 || <ref><pubmed>12649277</pubmed></ref>
|-
|-
| Small molecule || Maltose || 2002 || 3月1日 || <ref><pubmed>12097642</pubmed></ref>
| Small molecule || Maltose || 2002 || 3-1 || <ref><pubmed>12097642</pubmed></ref>
|-
|-
| Small molecule || Ribose || 2003 || 3月1日 || <ref><pubmed>14550551</pubmed></ref>
| Small molecule || Ribose || 2003 || 3-1 || <ref><pubmed>14550551</pubmed></ref>
|-
|-
| Kinase || Calcium/Calmodulin-dependent protein kinase II (CaMKII) || 2005, 2009, 2011, 2013 || 3月1日 || <ref><pubmed>15788767, 19295602, 23602566, 21506563</pubmed></ref>
| Kinase || Calcium/Calmodulin-dependent protein kinase II (CaMKII) || 2005, 2009, 2011, 2013 || 3-1 || <ref><pubmed>15788767</pubmed></ref><ref><pubmed> 19295602</pubmed></ref><ref><pubmed> 23602566</pubmed></ref><ref><pubmed> 21506563</pubmed></ref>
|-
|-
| Kinase || Src || 2005, 2005, 2007 || 3月3日 || <ref><pubmed>11752449, 15846350, 17284441</pubmed></ref>
| Kinase || Src || 2005, 2005, 2007 || 3-3 || <ref><pubmed>11752449</pubmed></ref><ref><pubmed> 15846350</pubmed></ref><ref><pubmed> 17284441</pubmed></ref>
|-
|-
| Kinase || Protein kinase C (PKC) || 2003, 2005 || 3-3, 3-1 || <ref><pubmed>12782683, 15611119</pubmed></ref>
| Kinase || Protein kinase C (PKC) || 2003, 2005 || 3-3, 3-1 || <ref><pubmed>12782683</pubmed></ref><ref><pubmed> 15611119</pubmed></ref>
|-
|-
| Kinase || Protein kinase D (PKD) || 2007 || 3月3日 || <ref><pubmed>17189263</pubmed></ref>
| Kinase || Protein kinase D (PKD) || 2007 || 3-3 || <ref><pubmed>17189263</pubmed></ref>
|-
|-
| Kinase || Protein kinase A (PKA) || 2000, 2001 || 3月3日 || <ref><pubmed>10700148, 11752448</pubmed></ref>
| Kinase || Protein kinase A (PKA) || 2000, 2001 || 3-3 || <ref><pubmed>10700148, 11752448</pubmed></ref>
|- Table 1 A list of genetically encoded FRET probes.
|- Table 1 A list of genetically encoded FRET probes.
| Kinase || Abl || 2001 || 3月3日 || <ref><pubmed>11752449</pubmed></ref>
| Kinase || Abl || 2001 || 3-3 || <ref><pubmed>11752449</pubmed></ref>
|-
|-
| Kinase || Bcr-Abl || 2010 || 3月3日 || <ref><pubmed>20817824</pubmed></ref>
| Kinase || Bcr-Abl || 2010 || 3-3 || <ref><pubmed>20817824</pubmed></ref>
|- The numbers in the Probe Design column correspond to the section number in the “Strategies of probe design” chapter of the main text. See the webpage by Dr. Michiyuki Matsuda http://www.lif.kyoto-u.ac.jp/labs/fret/e-phogemon/unifret.htm for updated information.
|- The numbers in the Probe Design column correspond to the section number in the “Strategies of probe design” chapter of the main text. See the webpage by Dr. Michiyuki Matsuda http://www.lif.kyoto-u.ac.jp/labs/fret/e-phogemon/unifret.htm for updated information.
| Kinase || c-Raf || 2005 || 3月1日 || <ref><pubmed>15711535</pubmed></ref>
| Kinase || c-Raf || 2005 || 3-1 || <ref><pubmed>15711535</pubmed></ref>
|-
|-
| Kinase || PAK1 || 2009 || 3月1日 || <ref><pubmed>19574218</pubmed></ref>
| Kinase || PAK1 || 2009 || 3-1 || <ref><pubmed>19574218</pubmed></ref>
|-
|-
| Kinase || B-raf || 2006 || 3月1日 || <ref><pubmed>16858395</pubmed></ref>
| Kinase || B-raf || 2006 || 3-1 || <ref><pubmed>16858395</pubmed></ref>
|-
|-
| Kinase || ZAP-70 || 2008 || 3月3日 || <ref><pubmed>18231606</pubmed></ref>
| Kinase || ZAP-70 || 2008 || 3-3 || <ref><pubmed>18231606</pubmed></ref>
|-
|-
| Kinase || Akt || 2003, 2005, 2007 || 3月3日 || <ref><pubmed>12773546, 15583002, 17407381</pubmed></ref>
| Kinase || Akt || 2003, 2005, 2007 || 3-3 || <ref><pubmed>12773546</pubmed></ref><ref><pubmed> 15583002</pubmed></ref><ref><pubmed> 17407381</pubmed></ref>
|-
|-
| Kinase || ERK || 2006, 2007, 2008 || 3-1,3-3,3-3 || <ref><pubmed>16418172, 17261026, 19033456</pubmed></ref>
| Kinase || ERK || 2006, 2007, 2008 || 3-1,3-3,3-3 || <ref><pubmed>16418172</pubmed></ref><ref><pubmed> 17261026</pubmed></ref><ref><pubmed> 19033456</pubmed></ref>
|-
|-
| Kinase || Insulin receptor || 2002 || 3月3日 || <ref><pubmed>11875431</pubmed></ref>
| Kinase || Insulin receptor || 2002 || 3-3 || <ref><pubmed>11875431</pubmed></ref>
|-
|-
| Kinase || Epidermal Growth factor receptor (EGFR) || 2001 || 3月3日 || <ref><pubmed>11752449</pubmed></ref>
| Kinase || Epidermal Growth factor receptor (EGFR) || 2001 || 3-3 || <ref><pubmed>11752449</pubmed></ref>
|-
|-
| Kinase || Ataxia telangiectasia mutated (ATM) || 2007 || 3月3日 || <ref><pubmed>17428747</pubmed></ref>
| Kinase || Ataxia telangiectasia mutated (ATM) || 2007 || 3-3 || <ref><pubmed>17428747</pubmed></ref>
|-
|-
| Kinase || Aurora B kinase || 2008 || 3月3日 || <ref><pubmed>18463638</pubmed></ref>
| Kinase || Aurora B kinase || 2008 || 3-3 || <ref><pubmed>18463638</pubmed></ref>
|-
|-
| Kinase || Cyclin B1-CDK1 || 2010 || 3月3日 || <ref><pubmed>20412769</pubmed></ref>
| Kinase || Cyclin B1-CDK1 || 2010 || 3-3 || <ref><pubmed>20412769</pubmed></ref>
|-
|-
| Kinase || Myosine light chain kinase || 2002 || 3月1日 || <ref><pubmed>11815633</pubmed></ref>
| Kinase || Myosine light chain kinase || 2002 || 3-1 || <ref><pubmed>11815633</pubmed></ref>
|-
|-
| Kinase || JNK || 2010, 2011 || 3月3日 || <ref><pubmed>20212108, 21976697</pubmed></ref>
| Kinase || JNK || 2010, 2011 || 3-3 || <ref><pubmed>20212108</pubmed></ref><ref><pubmed> 21976697</pubmed></ref>
|-
|-
| Kinase || RSK || 2011 || 3月3日 || <ref><pubmed>21976697</pubmed></ref>
| Kinase || RSK || 2011 || 3-3 || <ref><pubmed>21976697</pubmed></ref>
|-
|-
| Kinase || S6K || 2011 || 3月3日 || <ref><pubmed>21976697</pubmed></ref>
| Kinase || S6K || 2011 || 3-3 || <ref><pubmed>21976697</pubmed></ref>
|-
|-
| Kinase || Focal Adhesion Kinase (FAK) || 2008, 2009 || 2, 3-1 || <ref><pubmed>17967873, 19208768</pubmed></ref>
| Kinase || Focal Adhesion Kinase (FAK) || 2008, 2009 || 2, 3-1 || <ref><pubmed>17967873</pubmed></ref><ref><pubmed> 19208768</pubmed></ref>
|-
|-
| Kinase || PLK1 || 2008 || 3月3日 || <ref><pubmed>18615013</pubmed></ref>
| Kinase || PLK1 || 2008 || 3-3 || <ref><pubmed>18615013</pubmed></ref>
|-
|-
| Kinase || SAP3K || 2009 || 3月3日 || <ref><pubmed>19737916</pubmed></ref>
| Kinase || SAP3K || 2009 || 3-3 || <ref><pubmed>19737916</pubmed></ref>
|-
|-
| Kinase || DAPK1 || 2011 || 3月1日 || <ref><pubmed>21506563</pubmed></ref>
| Kinase || DAPK1 || 2011 || 3-1 || <ref><pubmed>21506563</pubmed></ref>
|-
|-
| Phosphatase || Calcineurin || 2008, 2013 || 3月1日 || <ref><pubmed>23602566, 18493642</pubmed></ref>
| Phosphatase || Calcineurin || 2008, 2013 || 3-1 || <ref><pubmed>23602566</pubmed></ref><ref><pubmed> 18493642</pubmed></ref>
|-
|-
| Small GTPase || Ras || 2001, 2006 || 3-2,2 || <ref><pubmed>16429133, 11429608</pubmed></ref>
| Small GTPase || Ras || 2001, 2006 || 3-2,2 || <ref><pubmed>16429133</pubmed></ref><ref><pubmed> 11429608</pubmed></ref>
|-
|-
| Small GTPase || Rap || 2001 || 3月2日 || <ref><pubmed>11429608</pubmed></ref>
| Small GTPase || Rap || 2001 || 3-2 || <ref><pubmed>11429608</pubmed></ref>
|-
|-
| Small GTPase || Rac || 2004 || 3月2日 || <ref><pubmed>14570905</pubmed></ref>
| Small GTPase || Rac || 2004 || 3-2 || <ref><pubmed>14570905</pubmed></ref>
|-
|-
| Small GTPase || Rab5 || 2008 || 3月2日 || <ref><pubmed>18385674</pubmed></ref>
| Small GTPase || Rab5 || 2008 || 3-2 || <ref><pubmed>18385674</pubmed></ref>
|-
|-
| Small GTPase || Rho || 2003, 2011 || 3-2, 2 || <ref><pubmed>21423166, 12860967</pubmed></ref>
| Small GTPase || Rho || 2003, 2011 || 3-2, 2 || <ref><pubmed>21423166</pubmed></ref><ref><pubmed> 12860967</pubmed></ref>
|-
|-
| Small GTPase || Cdc42 || 2004, 2011 || 3-2, 2 || <ref><pubmed>14570905, 21423166</pubmed></ref>
| Small GTPase || Cdc42 || 2004, 2011 || 3-2, 2 || <ref><pubmed>14570905</pubmed></ref><ref><pubmed> 21423166</pubmed></ref>
|-
|-
| Small GTPase || Ral || 2004 || 3月3日 || <ref><pubmed>15034142</pubmed></ref>
| Small GTPase || Ral || 2004 || 3-3 || <ref><pubmed>15034142</pubmed></ref>
|-
|-
| Small GTPase || TC10 || 2006 || 3月2日 || <ref><pubmed>16950130</pubmed></ref>
| Small GTPase || TC10 || 2006 || 3-2 || <ref><pubmed>16950130</pubmed></ref>
|-
|-
| Signal transduction || RCC1(GEF of Ran) || 2008 || 3月1日 || <ref><pubmed>18762580</pubmed></ref>
| Signal transduction || RCC1(GEF of Ran) || 2008 || 3-1 || <ref><pubmed>18762580</pubmed></ref>
|-
|-
| Signal transduction || CrkII phosphorylation || 2001 || 3月1日 || <ref><pubmed>11406630</pubmed></ref>
| Signal transduction || CrkII phosphorylation || 2001 || 3-1 || <ref><pubmed>11406630</pubmed></ref>
|-
|-
| Signal transduction || N-WASP || 2004 || 3月1日 || <ref><pubmed>15084285, 14732696</pubmed></ref>
| Signal transduction || N-WASP || 2004 || 3-1 || <ref><pubmed>15084285</pubmed></ref><ref><pubmed> 14732696</pubmed></ref>
|-
|-
| Signal transduction || Adrenergic receptor || 2003 || 3月1日 || <ref><pubmed>12808462</pubmed></ref>
| Signal transduction || Adrenergic receptor || 2003 || 3-1 || <ref><pubmed>12808462</pubmed></ref>
|-
|-
| Signal transduction || Parathyroid hormone receptor || 2003 || 3月1日 || <ref><pubmed>12808462</pubmed></ref>
| Signal transduction || Parathyroid hormone receptor || 2003 || 3-1 || <ref><pubmed>12808462</pubmed></ref>
|-
|-
| Signal transduction || Plasma membrane Calcium pump || 2007 || 3月1日 || <ref><pubmed>17901055</pubmed></ref>
| Signal transduction || Plasma membrane Calcium pump || 2007 || 3-1 || <ref><pubmed>17901055</pubmed></ref>
|-
|-
| Acetylation || Histone acetylation || 2004, 2009 || 3月3日 || <ref><pubmed>15137760, 19805290</pubmed></ref>
| Acetylation || Histone acetylation || 2004, 2009 || 3-3 || <ref><pubmed>15137760</pubmed></ref><ref><pubmed> 19805290</pubmed></ref>
|-
|-
| Lipid || Phosphatidylinositol (3,4,5)-trisphosphate (PIP3) || 2003 || 3月4日 || <ref><pubmed>14528311</pubmed></ref>
| Lipid || Phosphatidylinositol (3,4,5)-trisphosphate (PIP3) || 2003 || 3-4 || <ref><pubmed>14528311</pubmed></ref>
|-
|-
| Lipid || Phosphatidylinositol (4,5)-bisphosphate (PIP2) || 2008 || 3月4日 || <ref><pubmed>18685081</pubmed></ref>
| Lipid || Phosphatidylinositol (4,5)-bisphosphate (PIP2) || 2008 || 3-4 || <ref><pubmed>18685081</pubmed></ref>
|-
|-
| Lipid || Phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P2) || 2008 || 3月4日 || <ref><pubmed>18685081</pubmed></ref>
| Lipid || Phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P2) || 2008 || 3-4 || <ref><pubmed>18685081</pubmed></ref>
|-
|-
| Lipid || Phosphatidylinositol 4-phosphate (PI4P) || 2008 || 3月4日 || <ref><pubmed>18685081</pubmed></ref>
| Lipid || Phosphatidylinositol 4-phosphate (PI4P) || 2008 || 3-4 || <ref><pubmed>18685081</pubmed></ref>
|-
|-
| Lipid || Phosphatidic acid || 2010 || 3月4日 || <ref><pubmed>20826779</pubmed></ref>
| Lipid || Phosphatidic acid || 2010 || 3-4 || <ref><pubmed>20826779</pubmed></ref>
|-
|-
| Lipid || Diacylglycerol (DAG) || 2006, 2008 || 3月4日 || <ref><pubmed>18685081, 16990811</pubmed></ref>
| Lipid || Diacylglycerol (DAG) || 2006, 2008 || 3-4 || <ref><pubmed>18685081</pubmed></ref><ref><pubmed> 16990811</pubmed></ref>
|-
|-
| Protein interaction || Actin || 2004, 2008 || 2 || <ref><pubmed>15361876, 18512154</pubmed></ref>
| Protein interaction || Actin || 2004, 2008 || 2 || <ref><pubmed>15361876</pubmed></ref><ref><pubmed> 18512154</pubmed></ref>
|-
|-
| Protein interaction || PDK1-Akt interaction || 2007 || 2 || <ref><pubmed>17407381</pubmed></ref>
| Protein interaction || PDK1-Akt interaction || 2007 || 2 || <ref><pubmed>17407381</pubmed></ref>
160行目: 162行目:
| Protease || Caspase-7 || 2006 || 1 || <ref><pubmed>17946841</pubmed></ref>
| Protease || Caspase-7 || 2006 || 1 || <ref><pubmed>17946841</pubmed></ref>
|-
|-
| Protease || Matrix Metalloproteinase (MMP) || 2007, 2008 || 1 || <ref><pubmed>17187878, 18441011</pubmed></ref>  
| Protease || Matrix Metalloproteinase (MMP) || 2007, 2008 || 1 || <ref><pubmed>17187878</pubmed></ref><ref><pubmed> 18441011</pubmed></ref>  
|-
|-
| Protease || Protease activity (Factor Xa) || 1996 || 1 || <ref><pubmed>8707050</pubmed></ref>
| Protease || Protease activity (Factor Xa) || 1996 || 1 || <ref><pubmed>8707050</pubmed></ref>
166行目: 168行目:
| Protease || Calpain activity || 2000 || 1 || <ref><pubmed>10688895</pubmed></ref>
| Protease || Calpain activity || 2000 || 1 || <ref><pubmed>10688895</pubmed></ref>
|-
|-
| Protease || Presenilin || 2009 || 3月1日 || <ref><pubmed>19924286</pubmed></ref>
| Protease || Presenilin || 2009 || 3-1 || <ref><pubmed>19924286</pubmed></ref>
|-
|-
| Other || Strain sensor || 2008 || 3月1日 || <ref><pubmed>18479457</pubmed></ref>
| Other || Strain sensor || 2008 || 3-1 || <ref><pubmed>18479457</pubmed></ref>
|-
|-
| Other || Membrane potential || 2001, 2008, 2012 || 3月1日 || <ref><pubmed>11454036, 18622396, 22958819</pubmed></ref>
| Other || Membrane potential || 2001, 2008, 2012 || 3-1 || <ref><pubmed>11454036</pubmed></ref><ref><pubmed> 18622396</pubmed></ref><ref><pubmed> 22958819</pubmed></ref>
|-
|-
| Other || Myosin II || 1998, 2006 || 3月1日 || <ref><pubmed>9845076, 16939200</pubmed></ref>
| Other || Myosin II || 1998, 2006 || 3-1 || <ref><pubmed>9845076</pubmed></ref><ref><pubmed> 16939200</pubmed></ref>
|-
|-
| Other || HIV Rev protein || 2005 || 3月1日 || <ref><pubmed>16013840</pubmed></ref>
| Other || HIV Rev protein || 2005 || 3-1 || <ref><pubmed>16013840</pubmed></ref>
|-
|-
| Other || Redox || 2010, 2011 || 3月1日 || <ref><pubmed>20498274, 21606117</pubmed></ref>
| Other || Redox || 2010, 2011 || 3-1 || <ref><pubmed>20498274</pubmed></ref><ref><pubmed> 21606117</pubmed></ref>
|-
|-
}
}


<references />
<references />
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