「Propylpyrazoletriol」の版間の差分
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bsd>JWBE (removed Category:Phenols; added Category:4-Hydroxyphenyl compounds using HotCat) |
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2025年3月18日 (火) 19:33時点における最新版
| ファイル:Propylpyrazoletriol.svg | |
|---|---|
| Systematic (IUPAC) name | |
| 4-[2,3-bis(4-hydroxyphenyl)-4-propyl-1H-pyrazol-5-ylidene]cyclohexa-2,5-dien-1-one | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 263717-53-9 |
| ATC code | ? |
| PubChem | CID 6095481 |
| ChemSpider | 16142497 |
| UNII | 0T83Y6JZPF 
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| Chemical data | |
| Formula | C24H22N2O3 |
| SMILES | eMolecules & PubChem |
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Propylpyrazoletriol (PPT) is a synthetic, nonsteroidal agonist of ERα with 400-fold selectivity over ERβ[1] that is used widely in scientific research to study the function of ERα.[2][3][4] Though originally thought to be highly selective for ERα, PPT has subsequently been found to also act as an agonist of the GPER (GPR30).[5]
See also
References
- ↑ Weatherman RV (8 September 2008). "Untangling the Estrogen Receptor Web: Tools to Selectively Study Estrogen‐Binding Receptors". In Ottow E, Weinmann H (eds.). Nuclear Receptors as Drug Targets. Methods and Principles in Medicinal Chemistry. John Wiley & Sons. pp. 47–64 (50). doi:10.1002/9783527623297.ch3. ISBN 978-3-527-62330-3.
- ↑ Pfaus JG, Jones SL, Flanagan-Cato LM, Blaustein JD (15 November 2014). "Female sexual behavior: Hormonal Priming and Control". In Plant TM, Zeleznik AJ (eds.). Knobil and Neill's Physiology of Reproduction: Two-Volume Set. Vol. 2. Academic Press. pp. 2287-2370 (2311). ISBN 978-0-12-397769-4.
- ↑ Aguirre C, Jayaraman A, Pike C, Baudry M (December 2010). "Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-β". Journal of Neurochemistry. 115 (5): 1277–87. doi:10.1111/j.1471-4159.2010.07038.x. PMC 3010223. PMID 20977477.
- ↑ Mann MK (2008). Synthesis of Non-steroidal Estrogen Receptor Proteolysis Targeting Chimeric Molecules (PROTACS) (Ph.D. thesis). University of Illinois at Urbana-Champaign. pp. 11–.
- ↑ Prossnitz ER, Barton M (May 2014). "Estrogen biology: new insights into GPER function and clinical opportunities". Molecular and Cellular Endocrinology. 389 (1–2): 71–83. doi:10.1016/j.mce.2014.02.002. PMC 4040308. PMID 24530924.
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