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表1.
Classification Target Year Probe design References
Small molecule Calcium 1997 3-2 [1]
Small molecule Cyclic guanosine monophosphate (cGMP) 2000, 2001, 2006 3-1 [2][3][4]
Small molecule Cyclic adenosine monophosphate (cAMP) 2000,2004 2, 3-1 [5][6]
Small molecule Inositol trisphosphate (IP3) 2004, 2005, 2006 3-1 [7][8][9]
Small molecule Nitric oxide (NO) 2005, 2006 3-1 [10][11]
Small molecule Adenosine triphosphate (ATP) 2012 3-1 [12]
Small molecule Estrogen 2004 3-3 [13]
Small molecule Androgen 2006 3-3 [14]
Small molecule Glucocorticoid receptor ligands 2007 3-3 [15]
Small molecule Neurotrophic factor 2008 3-3 [16]
Small molecule Nuclear receptor 2007 3-2 [17]
Small molecule O-N-acetylglucosamine (O-GlcNAc) 2006 3-3 [18]
Small molecule Vitamin A (Retinoic acid) 2013 3-1 [19]
Small molecule Molybdate 2013 3-1 [20]
Small molecule Glutamate 2005 3-1 [21]
Small molecule Zn2+ 2009 2 [22]
Small molecule Cl- 2000 other [23]
Small molecule pH 2001 other [24]
Small molecule Glucose 2003 3-1 [25]
Small molecule Maltose 2002 3-1 [26]
Small molecule Ribose 2003 3-1 [27]
Kinase Calcium/Calmodulin-dependent protein kinase II (CaMKII) 2005, 2009, 2011, 2013 3-1 [28][29][30][31]
Kinase Src 2005, 2005, 2007 3-3 [32][33][34]
Kinase Protein kinase C (PKC) 2003, 2005 3-3, 3-1 [35][36]
Kinase Protein kinase D (PKD) 2007 3-3 [37]
Kinase Protein kinase A (PKA) 2000, 2001 3-3 [38]
Kinase Abl 2001 3-3 [39]
Kinase Bcr-Abl 2010 3-3 [40]
Kinase c-Raf 2005 3-1 [41]
Kinase PAK1 2009 3-1 [42]
Kinase B-raf 2006 3-1 [43]
Kinase ZAP-70 2008 3-3 [44]
Kinase Akt 2003, 2005, 2007 3-3 [45][46][47]
Kinase ERK 2006, 2007, 2008 3-1,3-3,3-3 [48][49][50]
Kinase Insulin receptor 2002 3-3 [51]
Kinase Epidermal Growth factor receptor (EGFR) 2001 3-3 [52]
Kinase Ataxia telangiectasia mutated (ATM) 2007 3-3 [53]
Kinase Aurora B kinase 2008 3-3 [54]
Kinase Cyclin B1-CDK1 2010 3-3 [55]
Kinase Myosine light chain kinase 2002 3-1 [56]
Kinase JNK 2010, 2011 3-3 [57][58]
Kinase RSK 2011 3-3 [59]
Kinase S6K 2011 3-3 [60]
Kinase Focal Adhesion Kinase (FAK) 2008, 2009 2, 3-1 [61][62]
Kinase PLK1 2008 3-3 [63]
Kinase SAP3K 2009 3-3 [64]
Kinase DAPK1 2011 3-1 [65]
Phosphatase Calcineurin 2008, 2013 3-1 [66][67]
Small GTPase Ras 2001, 2006 3-2,2 [68][69]
Small GTPase Rap 2001 3-2 [70]
Small GTPase Rac 2004 3-2 [71]
Small GTPase Rab5 2008 3-2 [72]
Small GTPase Rho 2003, 2011 3-2, 2 [73][74]
Small GTPase Cdc42 2004, 2011 3-2, 2 [75][76]
Small GTPase Ral 2004 3-3 [77]
Small GTPase TC10 2006 3-2 [78]
Signal transduction RCC1(GEF of Ran) 2008 3-1 [79]
Signal transduction CrkII phosphorylation 2001 3-1 [80]
Signal transduction N-WASP 2004 3-1 [81][82]
Signal transduction Adrenergic receptor 2003 3-1 [83]
Signal transduction Parathyroid hormone receptor 2003 3-1 [84]
Signal transduction Plasma membrane Calcium pump 2007 3-1 [85]
Acetylation Histone acetylation 2004, 2009 3-3 [86][87]
Lipid Phosphatidylinositol (3,4,5)-trisphosphate (PIP3) 2003 3-4 [88]
Lipid Phosphatidylinositol (4,5)-bisphosphate (PIP2) 2008 3-4 [89]
Lipid Phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P2) 2008 3-4 [90]
Lipid Phosphatidylinositol 4-phosphate (PI4P) 2008 3-4 [91]
Lipid Phosphatidic acid 2010 3-4 [92]
Lipid Diacylglycerol (DAG) 2006, 2008 3-4 [93][94]
Protein interaction Actin 2004, 2008 2 [95][96]
Protein interaction PDK1-Akt interaction 2007 2 [97]
Protein interaction Protein tyrosine phosphatase 1B-receptor tyrosine kinases (PTP 1B-RTKs) interaction 2002 2 [98]
Protein interaction Breast cancer resistance protein/ATP-binding cassette sub-family G member) BCRP/ABCG 2010 2 [99]
Protein interaction Cofiin-actin interaction 2008 2 [100]
Protein interaction PTEN-Myosin V interaction 2009 2 [101]
Protease Caspase-3 1998 1 [102]
Protease Caspase-8 2002 1 [103]
Protease Caspase-9 2011 1 [104]
Protease Caspase-7 2006 1 [105]
Protease Matrix Metalloproteinase (MMP) 2007, 2008 1 [106][107]
Protease Protease activity (Factor Xa) 1996 1 [108]
Protease Calpain activity 2000 1 [109]
Protease Presenilin 2009 3-1 [110]
Other Strain sensor 2008 3-1 [111]
Other Membrane potential 2001, 2008, 2012 3-1 [112][113][114]
Other Myosin II 1998, 2006 3-1 [115][116]
Other HIV Rev protein 2005 3-1 [117]
Other Redox 2010, 2011 3-1 [118][119]