テンプレート:PBB/2932

Glycogen synthase kinase 3 beta
PDB rendering based on 1gng.
Available structures PDB 1GNG​, 1H8F​, 1I09​, 1J1B​, 1J1C​, 1O9U​, 1PYX​, 1Q3D​, 1Q3W​, 1Q41​, 1Q4L​, 1Q5K​, 1R0E​, 1UV5​, 2JDO​, 2JDR​, 2JLD​, 2O5K​, 2OW3​, 2X39​, 2XH5​, 3CQU​, 3CQW​, 3DU8​, 3E87​, 3E88​, 3E8D​, 3F7Z​, 3F88​, 3GB2​, 3I4B​, 3L1S​, 3M1S​, 3PUP​, 3Q3B​, 3SAY​, 3SD0​, 3ZRK​, 3ZRL​, 3ZRM​, 4ACC​, 4ACD​, 4ACG​, 4ACH​, 4AFJ​, 4DIT​, 4EKK​
Identifiers
Symbol	GSK3B
External IDs	OMIM: 605004 MGI: 1861437 HomoloGene: 55629 GeneCards: GSK3B Gene
EC number	2.7.11.26 2.7.11.1, 2.7.11.26
Gene Ontology Molecular function • RNA polymerase II transcription factor binding • p53 binding • protein serine/threonine kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • beta-catenin binding • kinase activity • kinase activity • protein kinase binding • ubiquitin protein ligase binding • protein kinase A catalytic subunit binding • tau-protein kinase activity • NF-kappaB binding Cellular component • nucleus • nucleolus • cytoplasm • centrosome • cytosol • plasma membrane • beta-catenin destruction complex • beta-catenin destruction complex • Axin-APC-beta-catenin-GSK3B complex Biological process • epithelial to mesenchymal transition • positive regulation of cell-matrix adhesion • glycogen metabolic process • protein phosphorylation • ER overload response • epidermal growth factor receptor signaling pathway • axon guidance • fibroblast growth factor receptor signaling pathway • phosphorylation • peptidyl-serine phosphorylation • hippocampus development • negative regulation of protein complex assembly • positive regulation of protein complex assembly • negative regulation of protein binding • positive regulation of Rac GTPase activity • regulation of microtubule-based process • intracellular signal transduction • negative regulation of apoptotic process • negative regulation of glycogen biosynthetic process • positive regulation of protein catabolic process • positive regulation of protein export from nucleus • nerve growth factor receptor signaling pathway • phosphatidylinositol-mediated signaling • negative regulation of NFAT protein import into nucleus • canonical Wnt receptor signaling pathway • canonical Wnt receptor signaling pathway • superior temporal gyrus development • negative regulation of canonical Wnt receptor signaling pathway • negative regulation of type B pancreatic cell development • negative regulation of glycogen (starch) synthase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2932	56637
Ensembl	ENSG00000082701	ENSMUSG00000022812
UniProt	P49841	Q9WV60
RefSeq (mRNA)	NM_001146156.1	NM_019827.6
RefSeq (protein)	NP_001139628.1	NP_062801.1
Location (UCSC)	Chr 3: 119.54 – 119.81 Mb	Chr 16: 38.09 – 38.25 Mb
PubMed search	[1]	[2]