テンプレート:PBB/9353

Slit guidance ligand 2
ファイル:Protein SLIT2 PDB 2V70.png Rendering based on PDB 2V70​.
Available structures PDB 2V70​, 2V9S​, 2V9T​, 2WFH​
Identifiers
Symbols	SLIT2; SLIL3; Slit-2
External IDs	OMIM: 603746 MGI: 1315205 HomoloGene: 3516 GeneCards: SLIT2 Gene
Gene Ontology Molecular function • GTPase inhibitor activity • calcium ion binding • protein binding • heparin binding • identical protein binding • protein homodimerization activity • laminin-1 binding • proteoglycan binding • heparan sulfate proteoglycan binding • chemorepellent activity • Roundabout binding Cellular component • extracellular region • extracellular space • cytoplasm • plasma membrane • cell surface • membrane • extracellular exosome Biological process • metanephros development • ureteric bud development • in utero embryonic development • negative regulation of protein phosphorylation • cell migration involved in sprouting angiogenesis • negative regulation of leukocyte chemotaxis • axon guidance • motor neuron axon guidance • negative regulation of cell proliferation • negative regulation of lamellipodium assembly • negative regulation of endothelial cell migration • negative regulation of gene expression • negative regulation of smooth muscle cell migration • single organismal cell-cell adhesion • spinal cord development • chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration • chemorepulsion involved in postnatal olfactory bulb interneuron migration • corticospinal neuron axon guidance through spinal cord • negative regulation of cell growth • negative regulation of cell migration • negative regulation of axon extension • negative regulation of actin filament polymerization • retinal ganglion cell axon guidance • response to nutrient levels • cellular response to hormone stimulus • dorsal/ventral axon guidance • negative regulation of GTPase activity • Roundabout signaling pathway • positive regulation of apoptotic process • negative regulation of vascular permeability • branching morphogenesis of an epithelial tube • axon extension involved in axon guidance • negative regulation of inflammatory response • positive regulation of axonogenesis • negative chemotaxis • induction of negative chemotaxis • negative regulation of small GTPase mediated signal transduction • response to cortisol • mammary duct terminal end bud growth • apoptotic process involved in luteolysis • negative regulation of chemokine-mediated signaling pathway • cellular response to heparin • negative regulation of smooth muscle cell chemotaxis • negative regulation of mononuclear cell migration • negative regulation of neutrophil chemotaxis • negative regulation of monocyte chemotaxis • negative regulation of retinal ganglion cell axon guidance • negative regulation of cellular response to growth factor stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9353	20563
Ensembl	ENSG00000145147	ENSMUSG00000031558
UniProt	O94813	Q9R1B9
RefSeq (mRNA)	NM_001289135	NM_001291227
RefSeq (protein)	NP_001276064	NP_001278156
Location (UCSC)	Chr 4: 20.25 – 20.62 Mb	Chr 5: 47.98 – 48.31 Mb
PubMed search	[1]	[2]