テンプレート:PBB/1270

Ciliary neurotrophic factor
PDB rendering based on 1cnt.
Available structures PDB 1CNT​
Identifiers
Symbols	CNTF; HCNTF
External IDs	OMIM: 118945 MGI: 88439 HomoloGene: 8288 GeneCards: CNTF Gene
Gene Ontology Molecular function • cytokine activity • ciliary neurotrophic factor receptor binding • interleukin-6 receptor binding • growth factor activity Cellular component • extracellular space • nucleus • cytoplasm • cytosol • axon • cell projection cytoplasm • neuronal cell body • intracellular membrane-bounded organelle Biological process • signal transduction • multicellular organismal development • nervous system development • positive regulation of cell proliferation • positive regulation of phosphatidylinositol 3-kinase cascade • cell differentiation • positive regulation of cell growth • growth • positive regulation of tyrosine phosphorylation of Stat3 protein • positive regulation of MAPK cascade • negative regulation of neuron apoptosis • neuroprotection • positive regulation of JAK-STAT cascade • negative regulation of photoreceptor cell differentiation • regulation of retinal cell programmed cell death • positive regulation of hormone secretion • astrocyte activation • muscle organ morphogenesis • neuron development • positive regulation of axon regeneration • regulation of resting membrane potential • membrane hyperpolarization • ciliary neurotrophic factor-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1270	12803
Ensembl	ENSG00000242689	ENSMUSG00000079415
UniProt	P26441	P51642
RefSeq (mRNA)	NM_000614.3	NM_053007.2
RefSeq (protein)	NP_000605.1	NP_740756.1
Location (UCSC)	Chr 11: 58.39 – 58.39 Mb	Chr 19: 12.84 – 12.84 Mb
PubMed search	[1]	[2]