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…as the [[placenta]], and may similarly be mediated by [[cytochrome P450]] enzymes.<ref name="pmid9472688" /> Although estradiol is extensively converted into …

…the hydroxylation process in [[Estradiol|17β-E2]] also occurs in cerebral enzymes.<ref name=":3" /> …s due to SIRT1-mediated deacetylation of p53. Further examination of brain enzymes revealed that converting estrogens into their hydroxylated forms is a key… …

…ecular weight and stable structure, and they are able to interact with the enzymes and receptors of cells.<ref name=ososki>{{cite journal|last1=Ososki|first1= …olved in the biosynthesis of [[steroid]] hormones, and inhibition of these enzymes results in the interference with hormone [[metabolism]].<ref name="Amin">{{ …

…= Steroid 5alpha-reductases and 3alpha-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism | journal = Best Pract. Res. Clin. Endocrinol. Metab …

…> In addition, estetrol undergoes minimal phase I [[metabolism]] by CYP450 enzymes, but is conjugated via [[glucuronidation]] and to a lesser extent [[sulfati …

…then undergoes three iterations of [[malonyl-CoA]] resulting in (B), which enzymes [[chalcone synthase]] (CHS) and chalcone reductase (CHR) modify to obtain… …

…ation on EC 3.2.1.66 - quercitrinase">{{cite web | url = http://www.brenda-enzymes.org/php/result_flat.php4?ecno=3.2.1.66 | title = Information on EC 3.2.1.66 …cetin is one of the most effective inducers of the phase II detoxification enzymes.<ref name="pmid21277359">{{cite journal | vauthors=Procházková D, Boušová… …

…ular heartbeat]], [[cataract]]s, [[visual disturbance]]s, [[elevated liver enzymes]], [[endometrial hyperplasia]], and [[endometrial cancer]].<ref name="Rosen …pairment|vision changes]], and [[elevated transaminases|elevation of liver enzymes]] have been reported.<ref name="RosenthalBurchum2017" /><ref name="SchiffAr …

…aving no clinical relevance,<ref name="pmid11836281" /> the elevated liver enzymes associated with norethisterone acetate may have precluded its further devel …Laine K, Pelkonen O | title = Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone …

| metabolism = 75% by [[Cytochrome P450|CYP]] enzymes …

…>'''H Van Belle'''<br>R 24 571: A potent inhibitor of calmodulin-activated enzymes.<br>''Cell Calcium 2, 483-494'':1981</ref>など、さまざまな物質がカルモジュリン阻害剤として働くことが見出され …

…ngia vestita'' (Fabaceae): Alteration in the activities of some glycolytic enzymes in the cestode, ''Raillietina echinobothrida'' |journal=Parasitology Resear …

…outes appear to be more important. It does not inhibit any cytochrome P450 enzymes. Elimination is almost all via feces.<ref name=UKlabel2016/> …

…the backdoor pathway. In the absence of adequate levels of [[steroidogenic enzymes]] during fetal development, the [[Androgen backdoor pathway#Dihydrotestoste …in neurons, a common consequence of brain injury. It does so by inhibiting enzymes involved in the apoptosis pathway specifically concerning the mitochondria, …

…rone can sometimes cause [[hepatotoxicity]], for instance [[elevated liver enzymes]], [[cholestatic jaundice]], [[peliosis hepatis]], [[hepatoma]]s, and [[hep …

…M, Flockhart DA |date=September 2013 |title=Inhibition of cytochrome p450 enzymes by the e- and z-isomers of norendoxifen |journal=Drug Metabolism and Dispos …strogen receptor and the impact of genetic polymorphisms of phase I and II enzymes on their concentration levels in plasma |journal=Clinical Pharmacology and …

…ducts of [[Drug metabolism#Phase II – conjugation|phase II]] (conjugation) enzymes,<ref name="pmid30893846">{{cite journal | vauthors = Chimento A, De Amicis …

…]]s, and can also be [[hydroxylation|hydroxylated]] by [[cytochrome P450]] enzymes into [[catechol estrogen]]s such as [[2-hydroxyestrone]] and [[4-hydroxyest …