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    Spatiotemporal dynamics of guanosine 3',5'-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator. Proceedings of the National Academy of Sciences of the United States of America, 98(5), 2437-42. [PubMed:11226257] [PMC] [WorldCat] [DOI]
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    Fluorescent sensors for rapid monitoring of intracellular cGMP. Nature methods, 3(1), 23-5. [PubMed:16369548] [WorldCat] [DOI]
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    Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science (New York, N.Y.), 295(5560), 1711-5. [PubMed:11872839] [WorldCat] [DOI]
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    Novel single chain cAMP sensors for receptor-induced signal propagation. The Journal of biological chemistry, 279(36), 37215-8. [PubMed:15231839] [WorldCat] [DOI]
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    Fluorescent biosensor for quantitative real-time measurements of inositol 1,4,5-trisphosphate in single living cells. The Journal of biological chemistry, 279(37), 38095-8. [PubMed:15272011] [WorldCat] [DOI]
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    Locating inositol 1,4,5-trisphosphate in the nucleus and neuronal dendrites with genetically encoded fluorescent indicators. Analytical chemistry, 77(15), 4751-8. [PubMed:16053285] [WorldCat] [DOI]
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    Cytosolic inositol 1,4,5-trisphosphate dynamics during intracellular calcium oscillations in living cells. The Journal of cell biology, 173(5), 755-65. [PubMed:16754959] [PMC] [WorldCat] [DOI]
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    Imaging the nanomolar range of nitric oxide with an amplifier-coupled fluorescent indicator in living cells. Proceedings of the National Academy of Sciences of the United States of America, 102(41), 14515-20. [PubMed:16176986] [PMC] [WorldCat] [DOI]
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    Cell-based indicator to visualize picomolar dynamics of nitric oxide release from living cells. Analytical chemistry, 78(24), 8175-82. [PubMed:17165805] [WorldCat] [DOI]
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    A genetically encoded fluorescent indicator capable of discriminating estrogen agonists from antagonists in living cells. Analytical chemistry, 76(8), 2181-6. [PubMed:15080726] [WorldCat] [DOI]
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    Imaging of selective nuclear receptor modulator-induced conformational changes in the nuclear receptor to allow interaction with coactivator and corepressor proteins in living cells. Chembiochem : a European journal of chemical biology, 8(7), 737-43. [PubMed:17387660] [WorldCat] [DOI]
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    A cellular FRET-based sensor for beta-O-GlcNAc, a dynamic carbohydrate modification involved in signaling. Journal of the American Chemical Society, 128(46), 14768-9. [PubMed:17105262] [WorldCat] [DOI]
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    Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors. Proceedings of the National Academy of Sciences of the United States of America, 102(24), 8740-5. [PubMed:15939876] [PMC] [WorldCat] [DOI]
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    Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis. Nature methods, 6(10), 737-40. [PubMed:19718032] [PMC] [WorldCat] [DOI]
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    A genetically encoded ratiometric indicator for chloride: capturing chloride transients in cultured hippocampal neurons. Neuron, 27(3), 447-59. [PubMed:11055428] [WorldCat] [DOI]
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    In vivo imaging of the dynamics of glucose uptake in the cytosol of COS-7 cells by fluorescent nanosensors. The Journal of biological chemistry, 278(21), 19127-33. [PubMed:12649277] [WorldCat] [DOI]
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    Visualization of maltose uptake in living yeast cells by fluorescent nanosensors. Proceedings of the National Academy of Sciences of the United States of America, 99(15), 9846-51. [PubMed:12097642] [PMC] [WorldCat] [DOI]
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    Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. Cell reports, 3(4), 978-87. [PubMed:23602566] [WorldCat] [DOI]
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    Rapid development of genetically encoded FRET reporters. ACS chemical biology, 6(7), 685-91. [PubMed:21506563] [WorldCat] [DOI]
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    Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proceedings of the National Academy of Sciences of the United States of America, 98(26), 15003-8. [PubMed:11752449] [PMC] [WorldCat] [DOI]
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    Visualizing the mechanical activation of Src. Nature, 434(7036), 1040-5. [PubMed:15846350] [WorldCat] [DOI]
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    Epidermal growth factor directs sex-specific steroid signaling through Src activation. The Journal of biological chemistry, 282(14), 10697-706. [PubMed:17284441] [WorldCat] [DOI]
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    A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. The Journal of cell biology, 161(5), 899-909. [PubMed:12782683] [PMC] [WorldCat] [DOI]
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    Analysis by fluorescence resonance energy transfer of the interaction between ligands and protein kinase Cdelta in the intact cell. The Journal of biological chemistry, 280(9), 8164-71. [PubMed:15611119] [WorldCat] [DOI]
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    Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. The Journal of biological chemistry, 282(9), 6733-42. [PubMed:17189263] [PMC] [WorldCat] [DOI]
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    Zhang, J., Ma, Y., Taylor, S.S., & Tsien, R.Y. (2001).
    Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proceedings of the National Academy of Sciences of the United States of America, 98(26), 14997-5002. [PubMed:11752448] [PMC] [WorldCat] [DOI]
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    Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proceedings of the National Academy of Sciences of the United States of America, 98(26), 15003-8. [PubMed:11752449] [PMC] [WorldCat] [DOI]
  40. ↑ Tunceroglu, A., Matsuda, M., & Birge, R.B. (2010).
    Real-time fluorescent resonance energy transfer analysis to monitor drug resistance in chronic myelogenous leukemia. Molecular cancer therapeutics, 9(11), 3065-73. [PubMed:20817824] [PMC] [WorldCat] [DOI]
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    Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase. EMBO reports, 6(3), 251-5. [PubMed:15711535] [PMC] [WorldCat] [DOI]
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    Dissecting activation of the PAK1 kinase at protrusions in living cells. The Journal of biological chemistry, 284(36), 24133-43. [PubMed:19574218] [PMC] [WorldCat] [DOI]
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    The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf. The EMBO journal, 25(15), 3556-64. [PubMed:16858395] [PMC] [WorldCat] [DOI]
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    A novel ZAP-70 dependent FRET based biosensor reveals kinase activity at both the immunological synapse and the antisynapse. PloS one, 3(1), e1521. [PubMed:18231606] [PMC] [WorldCat] [DOI]
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    Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells. The Journal of biological chemistry, 278(33), 30945-51. [PubMed:12773546] [WorldCat] [DOI]
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    Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. The Journal of biological chemistry, 280(7), 5581-7. [PubMed:15583002] [PMC] [WorldCat] [DOI]
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    Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS biology, 5(4), e95. [PubMed:17407381] [PMC] [WorldCat] [DOI]
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    Genetically encoded fluorescent indicators to visualize protein phosphorylation by extracellular signal-regulated kinase in single living cells. Analytical chemistry, 79(6), 2570-5. [PubMed:17261026] [WorldCat] [DOI]
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    A genetically encoded fluorescent sensor of ERK activity. Proceedings of the National Academy of Sciences of the United States of America, 105(49), 19264-9. [PubMed:19033456] [PMC] [WorldCat] [DOI]
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    Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proceedings of the National Academy of Sciences of the United States of America, 98(26), 15003-8. [PubMed:11752449] [PMC] [WorldCat] [DOI]
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    Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient. Nature, 453(7198), 1132-6. [PubMed:18463638] [PMC] [WorldCat] [DOI]
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    Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis. Developmental cell, 18(4), 533-43. [PubMed:20412769] [PMC] [WorldCat] [DOI]
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    Development of an optimized backbone of FRET biosensors for kinases and GTPases. Molecular biology of the cell, 22(23), 4647-56. [PubMed:21976697] [PMC] [WorldCat] [DOI]
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    Development of an optimized backbone of FRET biosensors for kinases and GTPases. Molecular biology of the cell, 22(23), 4647-56. [PubMed:21976697] [PMC] [WorldCat] [DOI]
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    Dynamic conformational changes in the FERM domain of FAK are involved in focal-adhesion behavior during cell spreading and motility. Journal of cell science, 122(Pt 5), 656-66. [PubMed:19208768] [WorldCat] [DOI]
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    Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature, 455(7209), 119-23. [PubMed:18615013] [WorldCat] [DOI]
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    Stimulus-specific distinctions in spatial and temporal dynamics of stress-activated protein kinase kinase kinases revealed by a fluorescence resonance energy transfer biosensor. Molecular and cellular biology, 29(22), 6117-27. [PubMed:19737916] [PMC] [WorldCat] [DOI]
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    Rapid development of genetically encoded FRET reporters. ACS chemical biology, 6(7), 685-91. [PubMed:21506563] [WorldCat] [DOI]
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    Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. Cell reports, 3(4), 978-87. [PubMed:23602566] [WorldCat] [DOI]
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    Visualization of phosphatase activity in living cells with a FRET-based calcineurin activity sensor. Molecular bioSystems, 4(6), 496-501. [PubMed:18493642] [WorldCat] [DOI]
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    Spatio-temporal images of growth-factor-induced activation of Ras and Rap1. Nature, 411(6841), 1065-8. [PubMed:11429608] [WorldCat] [DOI]
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  90. ↑ Nishioka, T., Aoki, K., Hikake, K., Yoshizaki, H., Kiyokawa, E., & Matsuda, M. (2008).
    Rapid turnover rate of phosphoinositides at the front of migrating MDCK cells. Molecular biology of the cell, 19(10), 4213-23. [PubMed:18685081] [PMC] [WorldCat] [DOI]
  91. ↑ Nishioka, T., Aoki, K., Hikake, K., Yoshizaki, H., Kiyokawa, E., & Matsuda, M. (2008).
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  92. ↑ Nishioka, T., Frohman, M.A., Matsuda, M., & Kiyokawa, E. (2010).
    Heterogeneity of phosphatidic acid levels and distribution at the plasma membrane in living cells as visualized by a Föster resonance energy transfer (FRET) biosensor. The Journal of biological chemistry, 285(46), 35979-87. [PubMed:20826779] [PMC] [WorldCat] [DOI]
  93. ↑ Nishioka, T., Aoki, K., Hikake, K., Yoshizaki, H., Kiyokawa, E., & Matsuda, M. (2008).
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  94. ↑ Sato, M., Ueda, Y., & Umezawa, Y. (2006).
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  96. ↑ Murakoshi, H., Lee, S.J., & Yasuda, R. (2008).
    Highly sensitive and quantitative FRET-FLIM imaging in single dendritic spines using improved non-radiative YFP. Brain cell biology, 36(1-4), 31-42. [PubMed:18512154] [PMC] [WorldCat] [DOI]
  97. ↑ Calleja, V., Alcor, D., Laguerre, M., Park, J., Vojnovic, B., Hemmings, B.A., ..., & Larijani, B. (2007).
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  98. ↑ Haj, F.G., Verveer, P.J., Squire, A., Neel, B.G., & Bastiaens, P.I. (2002).
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  99. ↑ Ni, Z., Mark, M.E., Cai, X., & Mao, Q. (2010).
    Fluorescence resonance energy transfer (FRET) analysis demonstrates dimer/oligomer formation of the human breast cancer resistance protein (BCRP/ABCG2) in intact cells. International journal of biochemistry and molecular biology, 1(1), 1-11. [PubMed:20622991] [PMC] [WorldCat]
  100. ↑ Homma, K., Niino, Y., Hotta, K., & Oka, K. (2008).
    Ca(2+) influx through P2X receptors induces actin cytoskeleton reorganization by the formation of cofilin rods in neurites. Molecular and cellular neurosciences, 37(2), 261-70. [PubMed:17993279] [WorldCat] [DOI]
  101. ↑ van Diepen, M.T., Parsons, M., Downes, C.P., Leslie, N.R., Hindges, R., & Eickholt, B.J. (2009).
    MyosinV controls PTEN function and neuronal cell size. Nature cell biology, 11(10), 1191-6. [PubMed:19767745] [PMC] [WorldCat] [DOI]
  102. ↑ Xu, X., Gerard, A.L., Huang, B.C., Anderson, D.C., Payan, D.G., & Luo, Y. (1998).
    Detection of programmed cell death using fluorescence energy transfer. Nucleic acids research, 26(8), 2034-5. [PubMed:9518501] [PMC] [WorldCat] [DOI]
  103. ↑ Onuki, R., Nagasaki, A., Kawasaki, H., Baba, T., Uyeda, T.Q., & Taira, K. (2002).
    Confirmation by FRET in individual living cells of the absence of significant amyloid beta -mediated caspase 8 activation. Proceedings of the National Academy of Sciences of the United States of America, 99(23), 14716-21. [PubMed:12409609] [PMC] [WorldCat] [DOI]
  104. ↑ Joseph, J., Seervi, M., Sobhan, P.K., & Retnabai, S.T. (2011).
    High throughput ratio imaging to profile caspase activity: potential application in multiparameter high content apoptosis analysis and drug screening. PloS one, 6(5), e20114. [PubMed:21637712] [PMC] [WorldCat] [DOI]
  105. ↑ Li, I.T., Chiang, J.J., & Truong, K. (2006).
    FRET evidence that an isoform of caspase-7 binds but does not cleave its substrate. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 1, 531-4. [PubMed:17946841] [WorldCat] [DOI]
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    Detection of MMP activity in living cells by a genetically encoded surface-displayed FRET sensor. Biochimica et biophysica acta, 1773(3), 400-7. [PubMed:17187878] [WorldCat] [DOI]
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表1．
Classification Target Year Probe design References
Small molecule Calcium 1997 3-2 [1]
Small molecule Cyclic guanosine monophosphate (cGMP) 2000, 2001, 2006 3-1 [2][3][4]
Small molecule Cyclic adenosine monophosphate (cAMP) 2000,2004 2, 3-1 [5][6]
Small molecule Inositol trisphosphate (IP3) 2004, 2005, 2006 3-1 [7][8][9]
Small molecule Nitric oxide (NO) 2005, 2006 3-1 [10][11]
Small molecule Adenosine triphosphate (ATP) 2012 3-1 [12]
Small molecule Estrogen 2004 3-3 [13]
Small molecule Androgen 2006 3-3 [14]
Small molecule Glucocorticoid receptor ligands 2007 3-3 [15]
Small molecule Neurotrophic factor 2008 3-3 [16]
Small molecule Nuclear receptor 2007 3-2 [17]
Small molecule O-N-acetylglucosamine (O-GlcNAc) 2006 3-3 [18]
Small molecule Vitamin A (Retinoic acid) 2013 3-1 [19]
Small molecule Molybdate 2013 3-1 [20]
Small molecule Glutamate 2005 3-1 [21]
Small molecule Zn2+ 2009 2 [22]
Small molecule Cl- 2000 other [23]
Small molecule pH 2001 other [24]
Small molecule Glucose 2003 3-1 [25]
Small molecule Maltose 2002 3-1 [26]
Small molecule Ribose 2003 3-1 [27]
Kinase Calcium/Calmodulin-dependent protein kinase II (CaMKII) 2005, 2009, 2011, 2013 3-1 [28][29][30][31]
Kinase Src 2005, 2005, 2007 3-3 [32][33][34]
Kinase Protein kinase C (PKC) 2003, 2005 3-3, 3-1 [35][36]
Kinase Protein kinase D (PKD) 2007 3-3 [37]
Kinase Protein kinase A (PKA) 2000, 2001 3-3 [38]
Kinase Abl 2001 3-3 [39]
Kinase Bcr-Abl 2010 3-3 [40]
Kinase c-Raf 2005 3-1 [41]
Kinase PAK1 2009 3-1 [42]
Kinase B-raf 2006 3-1 [43]
Kinase ZAP-70 2008 3-3 [44]
Kinase Akt 2003, 2005, 2007 3-3 [45][46][47]
Kinase ERK 2006, 2007, 2008 3-1,3-3,3-3 [48][49][50]
Kinase Insulin receptor 2002 3-3 [51]
Kinase Epidermal Growth factor receptor (EGFR) 2001 3-3 [52]
Kinase Ataxia telangiectasia mutated (ATM) 2007 3-3 [53]
Kinase Aurora B kinase 2008 3-3 [54]
Kinase Cyclin B1-CDK1 2010 3-3 [55]
Kinase Myosine light chain kinase 2002 3-1 [56]
Kinase JNK 2010, 2011 3-3 [57][58]
Kinase RSK 2011 3-3 [59]
Kinase S6K 2011 3-3 [60]
Kinase Focal Adhesion Kinase (FAK) 2008, 2009 2, 3-1 [61][62]
Kinase PLK1 2008 3-3 [63]
Kinase SAP3K 2009 3-3 [64]
Kinase DAPK1 2011 3-1 [65]
Phosphatase Calcineurin 2008, 2013 3-1 [66][67]
Small GTPase Ras 2001, 2006 3-2,2 [68][69]
Small GTPase Rap 2001 3-2 [70]
Small GTPase Rac 2004 3-2 [71]
Small GTPase Rab5 2008 3-2 [72]
Small GTPase Rho 2003, 2011 3-2, 2 [73][74]
Small GTPase Cdc42 2004, 2011 3-2, 2 [75][76]
Small GTPase Ral 2004 3-3 [77]
Small GTPase TC10 2006 3-2 [78]
Signal transduction RCC1(GEF of Ran) 2008 3-1 [79]
Signal transduction CrkII phosphorylation 2001 3-1 [80]
Signal transduction N-WASP 2004 3-1 [81][82]
Signal transduction Adrenergic receptor 2003 3-1 [83]
Signal transduction Parathyroid hormone receptor 2003 3-1 [84]
Signal transduction Plasma membrane Calcium pump 2007 3-1 [85]
Acetylation Histone acetylation 2004, 2009 3-3 [86][87]
Lipid Phosphatidylinositol (3,4,5)-trisphosphate (PIP3) 2003 3-4 [88]
Lipid Phosphatidylinositol (4,5)-bisphosphate (PIP2) 2008 3-4 [89]
Lipid Phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P2) 2008 3-4 [90]
Lipid Phosphatidylinositol 4-phosphate (PI4P) 2008 3-4 [91]
Lipid Phosphatidic acid 2010 3-4 [92]
Lipid Diacylglycerol (DAG) 2006, 2008 3-4 [93][94]
Protein interaction Actin 2004, 2008 2 [95][96]
Protein interaction PDK1-Akt interaction 2007 2 [97]
Protein interaction Protein tyrosine phosphatase 1B-receptor tyrosine kinases (PTP 1B-RTKs) interaction 2002 2 [98]
Protein interaction Breast cancer resistance protein/ATP-binding cassette sub-family G member) BCRP/ABCG 2010 2 [99]
Protein interaction Cofiin-actin interaction 2008 2 [100]
Protein interaction PTEN-Myosin V interaction 2009 2 [101]
Protease Caspase-3 1998 1 [102]
Protease Caspase-8 2002 1 [103]
Protease Caspase-9 2011 1 [104]
Protease Caspase-7 2006 1 [105]
Protease Matrix Metalloproteinase (MMP) 2007, 2008 1 [106][107]
Protease Protease activity (Factor Xa) 1996 1 [108]
Protease Calpain activity 2000 1 [109]
Protease Presenilin 2009 3-1 [110]
Other Strain sensor 2008 3-1 [111]
Other Membrane potential 2001, 2008, 2012 3-1 [112][113][114]
Other Myosin II 1998, 2006 3-1 [115][116]
Other HIV Rev protein 2005 3-1 [117]
Other Redox 2010, 2011 3-1 [118][119]
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