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- μ-Opioid receptor agonists (opioids) (e.g., morphine, heroin, hydrocodone, oxycodone, opium, kratom)
- α2δ subunit-containing voltage-dependent calcium channels blockers (gabapentinoids) (e.g., gabapentin, pregabalin, phenibut)
- AMPA receptor antagonists (e.g., perampanel)
- CB1 receptor agonists (cannabinoids) (e.g., THC, cannabis)
- Dopamine receptor agonists (e.g., levodopa)
- Dopamine releasing agents (e.g., amphetamine, methamphetamine, MDMA, mephedrone)
- Dopamine reuptake inhibitors (e.g., cocaine, methylphenidate)
- GABAA receptor positive allosteric modulators (e.g., barbiturates, benzodiazepines, carbamates, ethanol (alcohol) (alcoholic drink), inhalants, nonbenzodiazepines, quinazolinones)
- GHB (sodium oxybate) and analogues
- Glucocorticoids (corticosteroids) (e.g., dexamethasone, prednisone)
- nACh receptor agonists (e.g., nicotine, tobacco, arecoline, areca nut)
- Nitric oxide prodrugs (e.g., alkyl nitrites (poppers))
- NMDA receptor antagonists (e.g., DXM, ketamine, methoxetamine, nitrous oxide, phencyclidine, inhalants)
- Orexin receptor antagonists (e.g., suvorexant)
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