テンプレート:PBB/6722

Serum response factor (c-fos serum response element-binding transcription factor)
PDB rendering based on 1SRS. Protein Data Bank Japanwebページより出典
Available structures PDB 1HBX​, 1K6O​, 1SRS​
Identifiers
Symbols	SRF; MCM1
External IDs	OMIM: 600589 MGI: 106658 HomoloGene: 31135 GeneCards: SRF Gene
Gene Ontology Molecular function • RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity • RNA polymerase II transcription factor binding transcription factor activity • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription • chromatin binding • sequence-specific DNA binding transcription factor activity • sequence-specific distal enhancer binding RNA polymerase II transcription factor activity • protein binding • transcription factor binding • serum response element binding • protein homodimerization activity • sequence-specific DNA binding Cellular component • nuclear chromatin • nucleus • nucleolus • cytoplasm • cytoplasm • endoplasmic reticulum Biological process • patterning of blood vessels • in utero embryonic development • mesoderm formation • neuron migration • trophectodermal cell differentiation • heart looping • morphogenesis of an epithelial sheet • cell migration involved in sprouting angiogenesis • leukocyte differentiation • transcription from RNA polymerase II promoter • actin filament organization • cell-matrix adhesion • multicellular organismal development • gastrulation • heart development • long-term memory • negative regulation of cell proliferation • associative learning • response to toxin • response to hormone stimulus • epithelial structure maintenance • positive regulation of transcription via serum response element binding • hippocampus development • tangential migration from the subventricular zone to the olfactory bulb • contractile actin filament bundle assembly • regulation of cell adhesion • platelet activation • platelet formation • negative regulation of cell migration • neuron projection development • regulation of water loss via skin • response to cytokine stimulus • response to cytokine stimulus • megakaryocyte development • dorsal aorta morphogenesis • stress fiber assembly • skin morphogenesis • positive thymic T cell selection • sarcomere organization • positive regulation of cell differentiation • positive regulation of transcription from RNA polymerase II promoter • positive regulation of smooth muscle contraction • muscle cell homeostasis • developmental growth • neuron development • erythrocyte development • regulation of smooth muscle cell differentiation • positive regulation of filopodium assembly • cardiac myofibril assembly • angiogenesis involved in wound healing • hemopoietic stem cell differentiation • positive regulation of transcription initiation from RNA polymerase II promoter • long term synaptic depression • heart trabecula formation • cardiac vascular smooth muscle cell differentiation • eyelid development in camera-type eye • tight junction assembly • primitive streak formation • epithelial cell-cell adhesion • cellular senescence Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6722	20807
Ensembl	ENSG00000112658	ENSMUSG00000015605
UniProt	P11831	Q9JM73
RefSeq (mRNA)	NM_003131.2	NM_020493.2
RefSeq (protein)	NP_003122.1	NP_065239.1
Location (UCSC)	Chr 6: 43.14 – 43.15 Mb	Chr 17: 46.68 – 46.69 Mb
PubMed search	[1]	[2]