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2013年10月3日 (木) 10:16時点における版

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[[wj:酵素#発見|test]]
{| class="wikitable" style="float:right"
|+ 表1．
Classification ­­­Target Year Probe design References
| Small molecule || Calcium || 1997 || 3月2日 || <ref><pubmed>9278050</pubmed></ref>
|-
| Small molecule || Cyclic guanosine monophosphate (cGMP) || 2000, 2001, 2006 || 3月1日 || <ref><pubmed>11140757, 11226257, 16369548</pubmed></ref>
|-
| Small molecule || Cyclic adenosine monophosphate (cAMP) || 2000, 2004 || 2, 3-1 || <ref><pubmed>11872839, 15231839</pubmed></ref>
|-
| Small molecule || Inositol trisphosphate (IP3) || 2004, 2005, 2006 || 3月1日 || <ref><pubmed>15272011, 16053285, 16754959</pubmed></ref>
|-
| Small molecule || Nitric oxide (NO) || 2005, 2006 || 3月1日 || <ref><pubmed>16176986, 17165805</pubmed></ref>
|-
| Small molecule || Adenosine triphosphate (ATP) || 2012 || 3月1日 || <ref><pubmed>19720993</pubmed></ref>
|-
| Small molecule || Estrogen || 2004 || 3月3日 || <ref><pubmed>15080726</pubmed></ref>
|-
| Small molecule || Androgen || 2006 || 3月3日 || <ref><pubmed>16555356</pubmed></ref>
|-
| Small molecule || Glucocorticoid receptor ligands || 2007 || 3月3日 || <ref><pubmed>17897691</pubmed></ref>
|-
| Small molecule || Neurotrophic factor || 2008 || 3月3日 || <ref><pubmed>18510313</pubmed></ref>
|-
| Small molecule || Nuclear receptor || 2007 || 3月2日 || <ref><pubmed>17387660</pubmed></ref>
|-
| Small molecule || O-N-acetylglucosamine (O-GlcNAc) || 2006 || 3月3日 || <ref><pubmed>17105262</pubmed></ref>
|-
| Small molecule || Vitamin A (Retinoic acid) || 2013 || 3月1日 || <ref><pubmed>23563268</pubmed></ref>
|-
| Small molecule || Molybdate || 2013 || 3月1日 || <ref><pubmed>23472155</pubmed></ref>
|-
| Small molecule || Glutamate || 2005 || 3月1日 || <ref><pubmed>15939876</pubmed></ref>
|-
| Small molecule || Zn2+ || 2009 || 2 || <ref><pubmed>19718032</pubmed></ref>
|-
| Small molecule || Cl- || 2000 || other || <ref><pubmed>11055428</pubmed></ref>
|-
| Small molecule || pH || 2001 || other || <ref><pubmed>11716495</pubmed></ref>
|-
| Small molecule || Glucose || 2003 || 3月1日 || <ref><pubmed>12649277</pubmed></ref>
|-
| Small molecule || Maltose || 2002 || 3月1日 || <ref><pubmed>12097642</pubmed></ref>
|-
| Small molecule || Ribose || 2003 || 3月1日 || <ref><pubmed>14550551</pubmed></ref>
|-
| Kinase || Calcium/Calmodulin-dependent protein kinase II (CaMKII) || 2005, 2009, 2011, 2013 || 3月1日 || <ref><pubmed>15788767, 19295602, 23602566, 21506563</pubmed></ref>
|-
| Kinase || Src || 2005, 2005, 2007 || 3月3日 || <ref><pubmed>11752449, 15846350, 17284441</pubmed></ref>
|-
| Kinase || Protein kinase C (PKC) || 2003, 2005 || 3-3, 3-1 || <ref><pubmed>12782683, 15611119</pubmed></ref>
|-
| Kinase || Protein kinase D (PKD) || 2007 || 3月3日 || <ref><pubmed>17189263</pubmed></ref>
|-
| Kinase || Protein kinase A (PKA) || 2000, 2001 || 3月3日 || <ref><pubmed>10700148, 11752448</pubmed></ref>
|- Table 1 A list of genetically encoded FRET probes.
| Kinase || Abl || 2001 || 3月3日 || <ref><pubmed>11752449</pubmed></ref>
|-
| Kinase || Bcr-Abl || 2010 || 3月3日 || <ref><pubmed>20817824</pubmed></ref>
|- The numbers in the Probe Design column correspond to the section number in the “Strategies of probe design” chapter of the main text. See the webpage by Dr. Michiyuki Matsuda http://www.lif.kyoto-u.ac.jp/labs/fret/e-phogemon/unifret.htm for updated information.
| Kinase || c-Raf || 2005 || 3月1日 || <ref><pubmed>15711535</pubmed></ref>
|-
| Kinase || PAK1 || 2009 || 3月1日 || <ref><pubmed>19574218</pubmed></ref>
|-
| Kinase || B-raf || 2006 || 3月1日 || <ref><pubmed>16858395</pubmed></ref>
|-
| Kinase || ZAP-70 || 2008 || 3月3日 || <ref><pubmed>18231606</pubmed></ref>
|-
| Kinase || Akt || 2003, 2005, 2007 || 3月3日 || <ref><pubmed>12773546, 15583002, 17407381</pubmed></ref>
|-
| Kinase || ERK || 2006, 2007, 2008 || 3-1,3-3,3-3 || <ref><pubmed>16418172, 17261026, 19033456</pubmed></ref>
|-
| Kinase || Insulin receptor || 2002 || 3月3日 || <ref><pubmed>11875431</pubmed></ref>
|-
| Kinase || Epidermal Growth factor receptor (EGFR) || 2001 || 3月3日 || <ref><pubmed>11752449</pubmed></ref>
|-
| Kinase || Ataxia telangiectasia mutated (ATM) || 2007 || 3月3日 || <ref><pubmed>17428747</pubmed></ref>
|-
| Kinase || Aurora B kinase || 2008 || 3月3日 || <ref><pubmed>18463638</pubmed></ref>
|-
| Kinase || Cyclin B1-CDK1 || 2010 || 3月3日 || <ref><pubmed>20412769</pubmed></ref>
|-
| Kinase || Myosine light chain kinase || 2002 || 3月1日 || <ref><pubmed>11815633</pubmed></ref>
|-
| Kinase || JNK || 2010, 2011 || 3月3日 || <ref><pubmed>20212108, 21976697</pubmed></ref>
|-
| Kinase || RSK || 2011 || 3月3日 || <ref><pubmed>21976697</pubmed></ref>
|-
| Kinase || S6K || 2011 || 3月3日 || <ref><pubmed>21976697</pubmed></ref>
|-
| Kinase || Focal Adhesion Kinase (FAK) || 2008, 2009 || 2, 3-1 || <ref><pubmed>17967873, 19208768</pubmed></ref>
|-
| Kinase || PLK1 || 2008 || 3月3日 || <ref><pubmed>18615013</pubmed></ref>
|-
| Kinase || SAP3K || 2009 || 3月3日 || <ref><pubmed>19737916</pubmed></ref>
|-
| Kinase || DAPK1 || 2011 || 3月1日 || <ref><pubmed>21506563</pubmed></ref>
|-
| Phosphatase || Calcineurin || 2008, 2013 || 3月1日 || <ref><pubmed>23602566, 18493642</pubmed></ref>
|-
| Small GTPase || Ras || 2001, 2006 || 3-2,2 || <ref><pubmed>16429133, 11429608</pubmed></ref>
|-
| Small GTPase || Rap || 2001 || 3月2日 || <ref><pubmed>11429608</pubmed></ref>
|-
| Small GTPase || Rac || 2004 || 3月2日 || <ref><pubmed>14570905</pubmed></ref>
|-
| Small GTPase || Rab5 || 2008 || 3月2日 || <ref><pubmed>18385674</pubmed></ref>
|-
| Small GTPase || Rho || 2003, 2011 || 3-2, 2 || <ref><pubmed>21423166, 12860967</pubmed></ref>
|-
| Small GTPase || Cdc42 || 2004, 2011 || 3-2, 2 || <ref><pubmed>14570905, 21423166</pubmed></ref>
|-
| Small GTPase || Ral || 2004 || 3月3日 || <ref><pubmed>15034142</pubmed></ref>
|-
| Small GTPase || TC10 || 2006 || 3月2日 || <ref><pubmed>16950130</pubmed></ref>
|-
| Signal transduction || RCC1(GEF of Ran) || 2008 || 3月1日 || <ref><pubmed>18762580</pubmed></ref>
|-
| Signal transduction || CrkII phosphorylation || 2001 || 3月1日 || <ref><pubmed>11406630</pubmed></ref>
|-
| Signal transduction || N-WASP || 2004 || 3月1日 || <ref><pubmed>15084285, 14732696</pubmed></ref>
|-
| Signal transduction || Adrenergic receptor || 2003 || 3月1日 || <ref><pubmed>12808462</pubmed></ref>
|-
| Signal transduction || Parathyroid hormone receptor || 2003 || 3月1日 || <ref><pubmed>12808462</pubmed></ref>
|-
| Signal transduction || Plasma membrane Calcium pump || 2007 || 3月1日 || <ref><pubmed>17901055</pubmed></ref>
|-
| Acetylation || Histone acetylation || 2004, 2009 || 3月3日 || <ref><pubmed>15137760, 19805290</pubmed></ref>
|-
| Lipid || Phosphatidylinositol (3,4,5)-trisphosphate (PIP3) || 2003 || 3月4日 || <ref><pubmed>14528311</pubmed></ref>
|-
| Lipid || Phosphatidylinositol (4,5)-bisphosphate (PIP2) || 2008 || 3月4日 || <ref><pubmed>18685081</pubmed></ref>
|-
| Lipid || Phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P2) || 2008 || 3月4日 || <ref><pubmed>18685081</pubmed></ref>
|-
| Lipid || Phosphatidylinositol 4-phosphate (PI4P) || 2008 || 3月4日 || <ref><pubmed>18685081</pubmed></ref>
|-
| Lipid || Phosphatidic acid || 2010 || 3月4日 || <ref><pubmed>20826779</pubmed></ref>
|-
| Lipid || Diacylglycerol (DAG) || 2006, 2008 || 3月4日 || <ref><pubmed>18685081, 16990811</pubmed></ref>
|-
| Protein interaction || Actin || 2004, 2008 || 2 || <ref><pubmed>15361876, 18512154</pubmed></ref>
|-
| Protein interaction || PDK1-Akt interaction || 2007 || 2 || <ref><pubmed>17407381</pubmed></ref>
|-
| Protein interaction || Protein tyrosine phosphatase 1B-receptor tyrosine kinases (PTP 1B-RTKs) interaction || 2002 || 2 || <ref><pubmed>11872838</pubmed></ref>
|-
| Protein interaction || Breast cancer resistance protein/ATP-binding cassette sub-family G member) BCRP/ABCG || 2010 || 2 || <ref><pubmed>20622991</pubmed></ref>
|-
| Protein interaction || Cofiin-actin interaction || 2008 || 2 || <ref><pubmed>17993279</pubmed></ref>
|-
| Protein interaction || PTEN-Myosin V interaction || 2009 || 2 || <ref><pubmed>19767745</pubmed></ref>
|-
| Protease || Caspase-3 || 1998 || 1 || <ref><pubmed>9518501</pubmed></ref>
|-
| Protease || Caspase-8 || 2002 || 1 || <ref><pubmed>12409609</pubmed></ref>
|-
| Protease || Caspase-9 || 2011 || 1 || <ref><pubmed>21637712</pubmed></ref>
|-
| Protease || Caspase-7 || 2006 || 1 || <ref><pubmed>17946841</pubmed></ref>
|-
| Protease || Matrix Metalloproteinase (MMP) || 2007, 2008 || 1 || <ref><pubmed>17187878, 18441011</pubmed></ref>
|-
| Protease || Protease activity (Factor Xa) || 1996 || 1 || <ref><pubmed>8707050</pubmed></ref>
|-
| Protease || Calpain activity || 2000 || 1 || <ref><pubmed>10688895</pubmed></ref>
|-
| Protease || Presenilin || 2009 || 3月1日 || <ref><pubmed>19924286</pubmed></ref>
|-
| Other || Strain sensor || 2008 || 3月1日 || <ref><pubmed>18479457</pubmed></ref>
|-
| Other || Membrane potential || 2001, 2008, 2012 || 3月1日 || <ref><pubmed>11454036, 18622396, 22958819</pubmed></ref>
|-
| Other || Myosin II || 1998, 2006 || 3月1日 || <ref><pubmed>9845076, 16939200</pubmed></ref>
|-
| Other || HIV Rev protein || 2005 || 3月1日 || <ref><pubmed>16013840</pubmed></ref>
|-
| Other || Redox || 2010, 2011 || 3月1日 || <ref><pubmed>20498274, 21606117</pubmed></ref>
|-
}


== PDBHandler Test ==
<references />
<nowiki>[[</nowiki>File:2A07.pdb]]
 
[[File:2A07.pdb]]
 
<nowiki>[[</nowiki>File:1BL8.pdb|200px|thumb|right|1BL8]]
[[File:1BL8.pdb|200px|thumb|right|1BL8]]
 
<nowiki><gallery></nowiki>
File:2A07.pdb|PDB Id: 2A07
File:1BL8.pdb|PDB Id: 1BL8
File:1RUZ.pdb|PDB Id: 1RUZ
File:7ICG.pdb|PDB Id: 7ICG
<nowiki></gallery></nowiki>
 
<gallery>
File:2A07.pdb|PDB Id: 2A07
File:1BL8.pdb|PDB Id: 1BL8
File:1RUZ.pdb|PDB Id: 1RUZ
File:7ICG.pdb|PDB Id: 7ICG
</gallery>
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