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{| class="wikitable | {| class="wikitable" | ||
|+ 表1. | |+ 表1. | ||
|- | |||
| Small molecule || Calcium || 1997 || | | Classification||Target ||Year||Probe design ||References | ||
|- | |||
| Small molecule || Calcium || 1997 || 3-2 || <ref><pubmed>9278050</pubmed></ref> | |||
|- | |- | ||
| Small molecule || Cyclic guanosine monophosphate (cGMP) || 2000, 2001, 2006 || | | Small molecule || Cyclic guanosine monophosphate (cGMP) || 2000, 2001, 2006 || 3-1 || <ref><pubmed>111407578</pubmed></ref><ref><pubmed>11226257</pubmed></ref><ref><pubmed>16369548</pubmed></ref> | ||
|- | |- | ||
| Small molecule || Cyclic adenosine monophosphate (cAMP) || 2000, 2004 || 2, 3-1 || <ref><pubmed>11872839 | | Small molecule || Cyclic adenosine monophosphate (cAMP) || 2000,2004 || 2, 3-1 || <ref><pubmed>11872839</pubmed></ref><ref><pubmed> 15231839</pubmed></ref> | ||
|- | |- | ||
| Small molecule || Inositol trisphosphate (IP3) || 2004, 2005, 2006 || | | Small molecule || Inositol trisphosphate (IP3) || 2004, 2005, 2006 || 3-1 || <ref><pubmed>15272011</pubmed></ref><ref><pubmed> 16053285</pubmed></ref><ref><pubmed> 16754959</pubmed></ref> | ||
|- | |- | ||
| Small molecule || Nitric oxide (NO) || 2005, 2006 || | | Small molecule || Nitric oxide (NO) || 2005, 2006 || 3-1 || <ref><pubmed>16176986</pubmed></ref><ref><pubmed> 17165805</pubmed></ref> | ||
|- | |- | ||
| Small molecule || Adenosine triphosphate (ATP) || 2012 || | | Small molecule || Adenosine triphosphate (ATP) || 2012 || 3-1 || <ref><pubmed>19720993</pubmed></ref> | ||
|- | |- | ||
| Small molecule || Estrogen || 2004 || | | Small molecule || Estrogen || 2004 || 3-3 || <ref><pubmed>15080726</pubmed></ref> | ||
|- | |- | ||
| Small molecule || Androgen || 2006 || | | Small molecule || Androgen || 2006 || 3-3 || <ref><pubmed>16555356</pubmed></ref> | ||
|- | |- | ||
| Small molecule || Glucocorticoid receptor ligands || 2007 || | | Small molecule || Glucocorticoid receptor ligands || 2007 || 3-3 || <ref><pubmed>17897691</pubmed></ref> | ||
|- | |- | ||
| Small molecule || Neurotrophic factor || 2008 || | | Small molecule || Neurotrophic factor || 2008 || 3-3 || <ref><pubmed>18510313</pubmed></ref> | ||
|- | |- | ||
| Small molecule || Nuclear receptor || 2007 || | | Small molecule || Nuclear receptor || 2007 || 3-2 || <ref><pubmed>17387660</pubmed></ref> | ||
|- | |- | ||
| Small molecule || O-N-acetylglucosamine (O-GlcNAc) || 2006 || | | Small molecule || O-N-acetylglucosamine (O-GlcNAc) || 2006 || 3-3 || <ref><pubmed>17105262</pubmed></ref> | ||
|- | |- | ||
| Small molecule || Vitamin A (Retinoic acid) || 2013 || | | Small molecule || Vitamin A (Retinoic acid) || 2013 || 3-1 || <ref><pubmed>23563268</pubmed></ref> | ||
|- | |- | ||
| Small molecule || Molybdate || 2013 || | | Small molecule || Molybdate || 2013 || 3-1 || <ref><pubmed>23472155</pubmed></ref> | ||
|- | |- | ||
| Small molecule || Glutamate || 2005 || | | Small molecule || Glutamate || 2005 || 3-1 || <ref><pubmed>15939876</pubmed></ref> | ||
|- | |- | ||
| Small molecule || Zn2+ || 2009 || 2 || <ref><pubmed>19718032</pubmed></ref> | | Small molecule || Zn2+ || 2009 || 2 || <ref><pubmed>19718032</pubmed></ref> | ||
38行目: | 40行目: | ||
| Small molecule || pH || 2001 || other || <ref><pubmed>11716495</pubmed></ref> | | Small molecule || pH || 2001 || other || <ref><pubmed>11716495</pubmed></ref> | ||
|- | |- | ||
| Small molecule || Glucose || 2003 || | | Small molecule || Glucose || 2003 || 3-1 || <ref><pubmed>12649277</pubmed></ref> | ||
|- | |- | ||
| Small molecule || Maltose || 2002 || | | Small molecule || Maltose || 2002 || 3-1 || <ref><pubmed>12097642</pubmed></ref> | ||
|- | |- | ||
| Small molecule || Ribose || 2003 || | | Small molecule || Ribose || 2003 || 3-1 || <ref><pubmed>14550551</pubmed></ref> | ||
|- | |- | ||
| Kinase || Calcium/Calmodulin-dependent protein kinase II (CaMKII) || 2005, 2009, 2011, 2013 || | | Kinase || Calcium/Calmodulin-dependent protein kinase II (CaMKII) || 2005, 2009, 2011, 2013 || 3-1 || <ref><pubmed>15788767</pubmed></ref><ref><pubmed> 19295602</pubmed></ref><ref><pubmed> 23602566</pubmed></ref><ref><pubmed> 21506563</pubmed></ref> | ||
|- | |- | ||
| Kinase || Src || 2005, 2005, 2007 || | | Kinase || Src || 2005, 2005, 2007 || 3-3 || <ref><pubmed>11752449</pubmed></ref><ref><pubmed> 15846350</pubmed></ref><ref><pubmed> 17284441</pubmed></ref> | ||
|- | |- | ||
| Kinase || Protein kinase C (PKC) || 2003, 2005 || 3-3, 3-1 || <ref><pubmed>12782683 | | Kinase || Protein kinase C (PKC) || 2003, 2005 || 3-3, 3-1 || <ref><pubmed>12782683</pubmed></ref><ref><pubmed> 15611119</pubmed></ref> | ||
|- | |- | ||
| Kinase || Protein kinase D (PKD) || 2007 || | | Kinase || Protein kinase D (PKD) || 2007 || 3-3 || <ref><pubmed>17189263</pubmed></ref> | ||
|- | |- | ||
| Kinase || Protein kinase A (PKA) || 2000, 2001 || | | Kinase || Protein kinase A (PKA) || 2000, 2001 || 3-3 || <ref><pubmed>10700148, 11752448</pubmed></ref> | ||
|- Table 1 A list of genetically encoded FRET probes. | |- Table 1 A list of genetically encoded FRET probes. | ||
| Kinase || Abl || 2001 || | | Kinase || Abl || 2001 || 3-3 || <ref><pubmed>11752449</pubmed></ref> | ||
|- | |- | ||
| Kinase || Bcr-Abl || 2010 || | | Kinase || Bcr-Abl || 2010 || 3-3 || <ref><pubmed>20817824</pubmed></ref> | ||
|- The numbers in the Probe Design column correspond to the section number in the “Strategies of probe design” chapter of the main text. See the webpage by Dr. Michiyuki Matsuda http://www.lif.kyoto-u.ac.jp/labs/fret/e-phogemon/unifret.htm for updated information. | |- The numbers in the Probe Design column correspond to the section number in the “Strategies of probe design” chapter of the main text. See the webpage by Dr. Michiyuki Matsuda http://www.lif.kyoto-u.ac.jp/labs/fret/e-phogemon/unifret.htm for updated information. | ||
| Kinase || c-Raf || 2005 || | | Kinase || c-Raf || 2005 || 3-1 || <ref><pubmed>15711535</pubmed></ref> | ||
|- | |- | ||
| Kinase || PAK1 || 2009 || | | Kinase || PAK1 || 2009 || 3-1 || <ref><pubmed>19574218</pubmed></ref> | ||
|- | |- | ||
| Kinase || B-raf || 2006 || | | Kinase || B-raf || 2006 || 3-1 || <ref><pubmed>16858395</pubmed></ref> | ||
|- | |- | ||
| Kinase || ZAP-70 || 2008 || | | Kinase || ZAP-70 || 2008 || 3-3 || <ref><pubmed>18231606</pubmed></ref> | ||
|- | |- | ||
| Kinase || Akt || 2003, 2005, 2007 || | | Kinase || Akt || 2003, 2005, 2007 || 3-3 || <ref><pubmed>12773546</pubmed></ref><ref><pubmed> 15583002</pubmed></ref><ref><pubmed> 17407381</pubmed></ref> | ||
|- | |- | ||
| Kinase || ERK || 2006, 2007, 2008 || 3-1,3-3,3-3 || <ref><pubmed>16418172 | | Kinase || ERK || 2006, 2007, 2008 || 3-1,3-3,3-3 || <ref><pubmed>16418172</pubmed></ref><ref><pubmed> 17261026</pubmed></ref><ref><pubmed> 19033456</pubmed></ref> | ||
|- | |- | ||
| Kinase || Insulin receptor || 2002 || | | Kinase || Insulin receptor || 2002 || 3-3 || <ref><pubmed>11875431</pubmed></ref> | ||
|- | |- | ||
| Kinase || Epidermal Growth factor receptor (EGFR) || 2001 || | | Kinase || Epidermal Growth factor receptor (EGFR) || 2001 || 3-3 || <ref><pubmed>11752449</pubmed></ref> | ||
|- | |- | ||
| Kinase || Ataxia telangiectasia mutated (ATM) || 2007 || | | Kinase || Ataxia telangiectasia mutated (ATM) || 2007 || 3-3 || <ref><pubmed>17428747</pubmed></ref> | ||
|- | |- | ||
| Kinase || Aurora B kinase || 2008 || | | Kinase || Aurora B kinase || 2008 || 3-3 || <ref><pubmed>18463638</pubmed></ref> | ||
|- | |- | ||
| Kinase || Cyclin B1-CDK1 || 2010 || | | Kinase || Cyclin B1-CDK1 || 2010 || 3-3 || <ref><pubmed>20412769</pubmed></ref> | ||
|- | |- | ||
| Kinase || Myosine light chain kinase || 2002 || | | Kinase || Myosine light chain kinase || 2002 || 3-1 || <ref><pubmed>11815633</pubmed></ref> | ||
|- | |- | ||
| Kinase || JNK || 2010, 2011 || | | Kinase || JNK || 2010, 2011 || 3-3 || <ref><pubmed>20212108</pubmed></ref><ref><pubmed> 21976697</pubmed></ref> | ||
|- | |- | ||
| Kinase || RSK || 2011 || | | Kinase || RSK || 2011 || 3-3 || <ref><pubmed>21976697</pubmed></ref> | ||
|- | |- | ||
| Kinase || S6K || 2011 || | | Kinase || S6K || 2011 || 3-3 || <ref><pubmed>21976697</pubmed></ref> | ||
|- | |- | ||
| Kinase || Focal Adhesion Kinase (FAK) || 2008, 2009 || 2, 3-1 || <ref><pubmed>17967873 | | Kinase || Focal Adhesion Kinase (FAK) || 2008, 2009 || 2, 3-1 || <ref><pubmed>17967873</pubmed></ref><ref><pubmed> 19208768</pubmed></ref> | ||
|- | |- | ||
| Kinase || PLK1 || 2008 || | | Kinase || PLK1 || 2008 || 3-3 || <ref><pubmed>18615013</pubmed></ref> | ||
|- | |- | ||
| Kinase || SAP3K || 2009 || | | Kinase || SAP3K || 2009 || 3-3 || <ref><pubmed>19737916</pubmed></ref> | ||
|- | |- | ||
| Kinase || DAPK1 || 2011 || | | Kinase || DAPK1 || 2011 || 3-1 || <ref><pubmed>21506563</pubmed></ref> | ||
|- | |- | ||
| Phosphatase || Calcineurin || 2008, 2013 || | | Phosphatase || Calcineurin || 2008, 2013 || 3-1 || <ref><pubmed>23602566</pubmed></ref><ref><pubmed> 18493642</pubmed></ref> | ||
|- | |- | ||
| Small GTPase || Ras || 2001, 2006 || 3-2,2 || <ref><pubmed>16429133 | | Small GTPase || Ras || 2001, 2006 || 3-2,2 || <ref><pubmed>16429133</pubmed></ref><ref><pubmed> 11429608</pubmed></ref> | ||
|- | |- | ||
| Small GTPase || Rap || 2001 || | | Small GTPase || Rap || 2001 || 3-2 || <ref><pubmed>11429608</pubmed></ref> | ||
|- | |- | ||
| Small GTPase || Rac || 2004 || | | Small GTPase || Rac || 2004 || 3-2 || <ref><pubmed>14570905</pubmed></ref> | ||
|- | |- | ||
| Small GTPase || Rab5 || 2008 || | | Small GTPase || Rab5 || 2008 || 3-2 || <ref><pubmed>18385674</pubmed></ref> | ||
|- | |- | ||
| Small GTPase || Rho || 2003, 2011 || 3-2, 2 || <ref><pubmed>21423166 | | Small GTPase || Rho || 2003, 2011 || 3-2, 2 || <ref><pubmed>21423166</pubmed></ref><ref><pubmed> 12860967</pubmed></ref> | ||
|- | |- | ||
| Small GTPase || Cdc42 || 2004, 2011 || 3-2, 2 || <ref><pubmed>14570905 | | Small GTPase || Cdc42 || 2004, 2011 || 3-2, 2 || <ref><pubmed>14570905</pubmed></ref><ref><pubmed> 21423166</pubmed></ref> | ||
|- | |- | ||
| Small GTPase || Ral || 2004 || | | Small GTPase || Ral || 2004 || 3-3 || <ref><pubmed>15034142</pubmed></ref> | ||
|- | |- | ||
| Small GTPase || TC10 || 2006 || | | Small GTPase || TC10 || 2006 || 3-2 || <ref><pubmed>16950130</pubmed></ref> | ||
|- | |- | ||
| Signal transduction || RCC1(GEF of Ran) || 2008 || | | Signal transduction || RCC1(GEF of Ran) || 2008 || 3-1 || <ref><pubmed>18762580</pubmed></ref> | ||
|- | |- | ||
| Signal transduction || CrkII phosphorylation || 2001 || | | Signal transduction || CrkII phosphorylation || 2001 || 3-1 || <ref><pubmed>11406630</pubmed></ref> | ||
|- | |- | ||
| Signal transduction || N-WASP || 2004 || | | Signal transduction || N-WASP || 2004 || 3-1 || <ref><pubmed>15084285</pubmed></ref><ref><pubmed> 14732696</pubmed></ref> | ||
|- | |- | ||
| Signal transduction || Adrenergic receptor || 2003 || | | Signal transduction || Adrenergic receptor || 2003 || 3-1 || <ref><pubmed>12808462</pubmed></ref> | ||
|- | |- | ||
| Signal transduction || Parathyroid hormone receptor || 2003 || | | Signal transduction || Parathyroid hormone receptor || 2003 || 3-1 || <ref><pubmed>12808462</pubmed></ref> | ||
|- | |- | ||
| Signal transduction || Plasma membrane Calcium pump || 2007 || | | Signal transduction || Plasma membrane Calcium pump || 2007 || 3-1 || <ref><pubmed>17901055</pubmed></ref> | ||
|- | |- | ||
| Acetylation || Histone acetylation || 2004, 2009 || | | Acetylation || Histone acetylation || 2004, 2009 || 3-3 || <ref><pubmed>15137760</pubmed></ref><ref><pubmed> 19805290</pubmed></ref> | ||
|- | |- | ||
| Lipid || Phosphatidylinositol (3,4,5)-trisphosphate (PIP3) || 2003 || | | Lipid || Phosphatidylinositol (3,4,5)-trisphosphate (PIP3) || 2003 || 3-4 || <ref><pubmed>14528311</pubmed></ref> | ||
|- | |- | ||
| Lipid || Phosphatidylinositol (4,5)-bisphosphate (PIP2) || 2008 || | | Lipid || Phosphatidylinositol (4,5)-bisphosphate (PIP2) || 2008 || 3-4 || <ref><pubmed>18685081</pubmed></ref> | ||
|- | |- | ||
| Lipid || Phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P2) || 2008 || | | Lipid || Phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P2) || 2008 || 3-4 || <ref><pubmed>18685081</pubmed></ref> | ||
|- | |- | ||
| Lipid || Phosphatidylinositol 4-phosphate (PI4P) || 2008 || | | Lipid || Phosphatidylinositol 4-phosphate (PI4P) || 2008 || 3-4 || <ref><pubmed>18685081</pubmed></ref> | ||
|- | |- | ||
| Lipid || Phosphatidic acid || 2010 || | | Lipid || Phosphatidic acid || 2010 || 3-4 || <ref><pubmed>20826779</pubmed></ref> | ||
|- | |- | ||
| Lipid || Diacylglycerol (DAG) || 2006, 2008 || | | Lipid || Diacylglycerol (DAG) || 2006, 2008 || 3-4 || <ref><pubmed>18685081</pubmed></ref><ref><pubmed> 16990811</pubmed></ref> | ||
|- | |- | ||
| Protein interaction || Actin || 2004, 2008 || 2 || <ref><pubmed>15361876 | | Protein interaction || Actin || 2004, 2008 || 2 || <ref><pubmed>15361876</pubmed></ref><ref><pubmed> 18512154</pubmed></ref> | ||
|- | |- | ||
| Protein interaction || PDK1-Akt interaction || 2007 || 2 || <ref><pubmed>17407381</pubmed></ref> | | Protein interaction || PDK1-Akt interaction || 2007 || 2 || <ref><pubmed>17407381</pubmed></ref> | ||
160行目: | 162行目: | ||
| Protease || Caspase-7 || 2006 || 1 || <ref><pubmed>17946841</pubmed></ref> | | Protease || Caspase-7 || 2006 || 1 || <ref><pubmed>17946841</pubmed></ref> | ||
|- | |- | ||
| Protease || Matrix Metalloproteinase (MMP) || 2007, 2008 || 1 || <ref><pubmed>17187878 | | Protease || Matrix Metalloproteinase (MMP) || 2007, 2008 || 1 || <ref><pubmed>17187878</pubmed></ref><ref><pubmed> 18441011</pubmed></ref> | ||
|- | |- | ||
| Protease || Protease activity (Factor Xa) || 1996 || 1 || <ref><pubmed>8707050</pubmed></ref> | | Protease || Protease activity (Factor Xa) || 1996 || 1 || <ref><pubmed>8707050</pubmed></ref> | ||
166行目: | 168行目: | ||
| Protease || Calpain activity || 2000 || 1 || <ref><pubmed>10688895</pubmed></ref> | | Protease || Calpain activity || 2000 || 1 || <ref><pubmed>10688895</pubmed></ref> | ||
|- | |- | ||
| Protease || Presenilin || 2009 || | | Protease || Presenilin || 2009 || 3-1 || <ref><pubmed>19924286</pubmed></ref> | ||
|- | |- | ||
| Other || Strain sensor || 2008 || | | Other || Strain sensor || 2008 || 3-1 || <ref><pubmed>18479457</pubmed></ref> | ||
|- | |- | ||
| Other || Membrane potential || 2001, 2008, 2012 || | | Other || Membrane potential || 2001, 2008, 2012 || 3-1 || <ref><pubmed>11454036</pubmed></ref><ref><pubmed> 18622396</pubmed></ref><ref><pubmed> 22958819</pubmed></ref> | ||
|- | |- | ||
| Other || Myosin II || 1998, 2006 || | | Other || Myosin II || 1998, 2006 || 3-1 || <ref><pubmed>9845076</pubmed></ref><ref><pubmed> 16939200</pubmed></ref> | ||
|- | |- | ||
| Other || HIV Rev protein || 2005 || | | Other || HIV Rev protein || 2005 || 3-1 || <ref><pubmed>16013840</pubmed></ref> | ||
|- | |- | ||
| Other || Redox || 2010, 2011 || | | Other || Redox || 2010, 2011 || 3-1 || <ref><pubmed>20498274</pubmed></ref><ref><pubmed> 21606117</pubmed></ref> | ||
|- | |- | ||
} | } | ||
<references /> | <references /> |