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| == 参考文献 == | | == 参考文献 == |
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| 1. ↑ Morgan, David O. (1997) "Cyclin-Dependent Kinase: Engines, Clocks, and Microprocessors." Annual Review of Cell and Developmental Biology. 13:261-291.
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| 2. ↑ Cdk5 book
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| 3. ↑ Patrick et al.(1998) p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. J Biol Chem. 273:24057-64.
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| 4. ↑ Patrick et al. (1999) Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature. 402(6762):615-22.
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| 5. ↑Smith et al. (2003) Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A. 100:13650-5.
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| 6. ↑Luo et al. (2005) Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity. J Cell Biol. 169:647-56.
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| 7. ↑Cheung et al. (2008) Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2. J Neurosci. 28:4872-7.
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| 8. ↑Odajima J. et al. (2011) Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell. 2011 Oct 18;21(4):655-68.
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| 9. ↑Hawasli AH. et al. (2007) Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nat. Neurosci. 10, 880-886.
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| 10. ↑Choi, JH. et al. (2010) Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature, 466, 451–456.
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| (執筆者:大島登志男 担当編集委員:尾藤 晴彦) | | (執筆者:大島登志男 担当編集委員:尾藤 晴彦) |