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====機能==== | ====機能==== | ||
Akt,Btk, | Akt,Btk,PDK1などのPHドメインと結合して、これらの分子を細胞膜に局在させる働きを持つ。これらの分子はPI3キナーゼシグナル伝達経路の活性化を起こす | ||
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== 参考文献 == | == 参考文献 == | ||
<references /> 1. Auger KR. et al. PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell, 7;57, 167-75. PMID: 2467744<br>2. Vicinanza M. et al. Function and dysfunction of the PI system in membrane trafficking. EMBO J., 27, 2457-2470 (1989). PMID: 18784754<br>3. Suetsugu S. et al. Subcellular membrane curvature mediated by the BAR domain superfamily proteins. Semin Cell Dev Biol., 21, 340-9 (2010). PMID: 19963073<br>4. Saarikangas J. et al. Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides. Physiol Rev. 90, 259-89 (2010). PMID: 20086078<br>5.Engelman J. A. et al. The evolution of phosphatidylinositol 3-kinasess as regulatos of growth and metabolism. Nature Reviews in Genetics, 7, 606-619 (2006) PMID: 16847462<br>6. McCrea H. J. and De Camilli P. Mutations in Phosphoinositide Metabolizing Exzymes and Human Disease Physiology 24, 8-16 (2009)PMID: 19196647 | <references /> 1. Auger KR. et al. PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell, 7;57, 167-75. PMID: 2467744<br>2. Vicinanza M. et al. Function and dysfunction of the PI system in membrane trafficking. EMBO J., 27, 2457-2470 (1989). PMID: 18784754<br>3. Suetsugu S. et al. Subcellular membrane curvature mediated by the BAR domain superfamily proteins. Semin Cell Dev Biol., 21, 340-9 (2010). PMID: 19963073<br>4. Saarikangas J. et al. Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides. Physiol Rev. 90, 259-89 (2010). PMID: 20086078<br>5.Engelman J. A. et al. The evolution of phosphatidylinositol 3-kinasess as regulatos of growth and metabolism. Nature Reviews in Genetics, 7, 606-619 (2006) PMID: 16847462<br>6. McCrea H. J. and De Camilli P. Mutations in Phosphoinositide Metabolizing Exzymes and Human Disease Physiology 24, 8-16 (2009)PMID: 19196647<br> |
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