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2013年10月8日 (火) 12:01時点におけるTfuruya (トーク | 投稿記録)による版

表1．
分類 対象 プローブ名 年 プローブデザイン 参考文献
生体内小分子 カルシウム Cameleon 1997 3-2 [1]
サイクリックGMP (cGMP) CGY, Cygnet, pGES-DE2, cGi 2000, 2001, 2006 3-1 [2][3][4]
サイクリックAMP (cAMP) Epac 2000,2004 2, 3-1 [5][6]
イノシトール3リン酸 (IP3) LIBRA, Fretino, FIRE 2004, 2005, 2006 3-1 [7][8][9]
一酸化窒素 (NO) NOA-1, Piccell 2005, 2006 3-1 [10][11]
アデノシン3リン酸 (ATP) A Team 1.03-nD/nA 2012 3-1 [12]
エストロゲン SCCoR 2004 3-3 [13]
アンドロゲン Ficaro 2006 3-3 [14]
グルココルチコイド受容体リガンド GLUCOCOR 2007 3-3 [15]
神経成長因子 ECaus 2008 3-3 [16]
核内受容体 conpro 2007 3-2 [17]
O-N-アセチルグルコサミン (O-GlcNAc) 2006 3-3 [18]
ビタミンA (レチノイン酸) GEPRAS 2013 3-1 [19]
モリブデン酸 MolyProbe 2013 3-1 [20]
グルタミン酸 FLIPE 2005 3-1 [21]
Zn2+ eCALWY-1 2009 2 [22]
Cl- Clomeleon 2000 other [23]
水素イオン濃度 (pH) GFpH, YFpH 2001 other [24]
グルコース FLIPglu 2003 3-1 [25]
マルトース FLIPmal 2002 3-1 [26]
リボース FLIPrib 2003 3-1 [27]
キナーゼ カルシウム/カルモジュリン依存製タンパク質キナーゼII (CaMKII) Camui α, green-Camui α, Camk2a reporter 2005, 2009, 2011, 2013 3-1 [28][29][30][31]
Src Srcus 2005, 2005, 2007 3-3 [32][33][34]
Protein kinase C (PKC) CKAR, CY-PKCdelta 2003, 2005 3-3, 3-1 [35][36]
Protein kinase D (PKD) DKAR 2007 3-3 [37]
Protein kinase A (PKA) ART, AKAR 2000, 2001 3-3 [38][39]
Abl Picchu 2001 3-3 [40]
Bcr-Abl Bcr-Abl activity sensor 2010 3-3 [41]
c-Raf Prin-cRaf 2005 3-1 [42]
PAK1 Pakabi 2009 3-1 [43]
B-raf Prin-Braf 2006 3-1 [44]
ZAP-70 ROZA 2008 3-3 [45]
Akt Aktus, BKAR, Akind 2003, 2005, 2007 3-3 [46][47][48]
ERK Miu2, Erkus, EKAR 2006, 2007, 2008 3-1,3-3,3-3 [49][50][51]
Insulin receptor Phocus 2002 3-3 [52]
Epidermal Growth factor receptor (EGFR) 2001 3-3 [53]
Ataxia telangiectasia mutated (ATM) 2007 3-3 [54]
Aurora B kinase 2008 3-3 [55]
Cyclin B1-CDK1 2010 3-3 [56]
Myosine light chain kinase MLCK-FIP 2002 3-1 [57]
JNK JNKAR1, JUNKAR1EV 2010, 2011 3-3 [58][59]
RSK Eevee-RSK 2011 3-3 [59]
S6K Eevee-S6K 2011 3-3 [59]
Focal Adhesion Kinase (FAK) CYFAK413, FERM-sensor 2008, 2009 2, 3-1 [60][61]
PLK1 2008 3-3 [62]
SAP3K 2009 3-3 [63]
DAPK1 DAPK1(334)-F40 2011 3-1 [64]
ホスファターゼ Calcineurin CaNAR1 2008, 2013 3-1 [65][66]
Small GTPase Ras Raichu-Ras, Fras 2001, 2006 3-2,2 [67][68]
Rap Raichu-Rap 2001 3-2 [68]
Rac Raichu-Rac1 2004 3-2 [69]
Rab5 Raichu-Rab5 2008 3-2 [70]
Rho Raichu-RhoA 2003, 2011 3-2, 2 [71][72]
Cdc42 Raichu-cdc42 2004, 2011 3-2, 2 [73][74]
Ral Raichu-Ral 2004 3-3 [75]
TC10 Raichu-TC10 2006 3-2 [76]
Signal transduction RCC1(GEF of Ran) CFP-RCC1-YFP 2008 3-1 [77]
CrkII phosphorylation Picchu 2001 3-1 [78]
N-WASP Stinger 2004 3-1 [79][80]
Adrenergic receptor α2AAR-cam 2003 3-1 [81]
Parathyroid hormone receptor PTHR-cam 2003 3-1 [81]
Plasma membrane Calcium pump BFP-PMCA-GFP 2007 3-1 [82]
Acetylation Histone acetylation Histac 2004, 2009 3-3 [83][84]
Lipid Phosphatidylinositol (3,4,5)-trisphosphate (PIP3) Fllip, FLIMPA 2003 3-4 [85]
Phosphatidylinositol (4,5)-bisphosphate (PIP2) Pippi-PI(4,5)P2 2008 3-4 [86]
Phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P2) Pippi-PI(3,4)P2 2008 3-4 [86]
Phosphatidylinositol 4-phosphate (PI4P) Pippi-PI(4)P 2008 3-4 [86]
Phosphatidic acid Pii 2010 3-4 [87]
Diacylglycerol (DAG) Daglas, DIGDA 2006, 2008 3-4 [88][89]
Protein interaction Actin 2004, 2008 2 [90][91]
PDK1-Akt interaction 2007 2 [92]
Protein tyrosine phosphatase 1B-receptor tyrosine kinases (PTP 1B-RTKs) interaction 2002 2 [93]
Breast cancer resistance protein/ATP-binding cassette sub-family G member) BCRP/ABCG 2010 2 [94]
Cofiin-actin interaction 2008 2 [95]
PTEN-Myosin V interaction 2009 2 [96]
Protease Caspase-3 EGFP-DEVD-EBFP 1998 1 [97]
Caspase-8 CFP-c3-YFP-c6-mRFP 2002 1 [98]
Caspase-9 SCAT9 2011 1 [99]
Caspase-7 VDEVDc 2006 1 [100]
Matrix Metalloproteinase (MMP) YFP-MSS-CFPdisplay, MTI-MMP-FRET biosensor 2007, 2008 1 [101][102]
Protease activity (Factor Xa) 1996 1 [103]
Calpain activity pYSCS 2000 1 [104]
Presenilin GFP-PSI-RFP 2009 3-1 [105]
Other Strain sensor stFRET 2008 3-1 [106]
Membrane potential VSFP, Mermaid, ArcLight, VSFP-Butterfly 2001, 2008, 2012 3-1 [107][108][109]
Myosin II GSldCB 1998, 2006 3-1 [110][111]
HIV Rev protein YRGnC-11ad 2005 3-1 [112]
レドックス Redoxfluor, Gaskins 2010, 2011 3-1 [113][114]

The numbers in the Probe Design column correspond to the section number in the “Strategies of probe design” chapter of the main text. See the webpage by Dr. Michiyuki Matsuda http://www.lif.kyoto-u.ac.jp/labs/fret/e-phogemon/unifret.htm for updated information.

  1. ↑ Miyawaki, A., Llopis, J., Heim, R., McCaffery, J.M., Adams, J.A., Ikura, M., & Tsien, R.Y. (1997).
    Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin. Nature, 388(6645), 882-7. [PubMed:9278050] [WorldCat] [DOI]
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    Fluorescent indicators for cyclic GMP based on cyclic GMP-dependent protein kinase Ialpha and green fluorescent proteins. Analytical chemistry, 72(24), 5918-24. [PubMed:11140757] [WorldCat] [DOI]
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    Spatiotemporal dynamics of guanosine 3',5'-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator. Proceedings of the National Academy of Sciences of the United States of America, 98(5), 2437-42. [PubMed:11226257] [PMC] [WorldCat] [DOI]
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    Fluorescent sensors for rapid monitoring of intracellular cGMP. Nature methods, 3(1), 23-5. [PubMed:16369548] [WorldCat] [DOI]
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    Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science (New York, N.Y.), 295(5560), 1711-5. [PubMed:11872839] [WorldCat] [DOI]
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    Novel single chain cAMP sensors for receptor-induced signal propagation. The Journal of biological chemistry, 279(36), 37215-8. [PubMed:15231839] [WorldCat] [DOI]
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    Fluorescent biosensor for quantitative real-time measurements of inositol 1,4,5-trisphosphate in single living cells. The Journal of biological chemistry, 279(37), 38095-8. [PubMed:15272011] [WorldCat] [DOI]
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    Locating inositol 1,4,5-trisphosphate in the nucleus and neuronal dendrites with genetically encoded fluorescent indicators. Analytical chemistry, 77(15), 4751-8. [PubMed:16053285] [WorldCat] [DOI]
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    Cytosolic inositol 1,4,5-trisphosphate dynamics during intracellular calcium oscillations in living cells. The Journal of cell biology, 173(5), 755-65. [PubMed:16754959] [PMC] [WorldCat] [DOI]
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    Imaging the nanomolar range of nitric oxide with an amplifier-coupled fluorescent indicator in living cells. Proceedings of the National Academy of Sciences of the United States of America, 102(41), 14515-20. [PubMed:16176986] [PMC] [WorldCat] [DOI]
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    Cell-based indicator to visualize picomolar dynamics of nitric oxide release from living cells. Analytical chemistry, 78(24), 8175-82. [PubMed:17165805] [WorldCat] [DOI]
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    A genetically encoded fluorescent indicator capable of discriminating estrogen agonists from antagonists in living cells. Analytical chemistry, 76(8), 2181-6. [PubMed:15080726] [WorldCat] [DOI]
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    A fluorescent indicator to visualize activities of the androgen receptor ligands in single living cells. Angewandte Chemie (International ed. in English), 45(17), 2707-12. [PubMed:16555356] [WorldCat] [DOI]
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    Optical probes to identify the glucocorticoid receptor ligands in living cells. Steroids, 72(14), 949-54. [PubMed:17897691] [WorldCat] [DOI]
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    Cell-based fluorescent indicator to visualize brain-derived neurotrophic factor secreted from living neurons. ACS chemical biology, 3(6), 352-8. [PubMed:18510313] [WorldCat] [DOI]
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    Imaging of selective nuclear receptor modulator-induced conformational changes in the nuclear receptor to allow interaction with coactivator and corepressor proteins in living cells. Chembiochem : a European journal of chemical biology, 8(7), 737-43. [PubMed:17387660] [WorldCat] [DOI]
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    A cellular FRET-based sensor for beta-O-GlcNAc, a dynamic carbohydrate modification involved in signaling. Journal of the American Chemical Society, 128(46), 14768-9. [PubMed:17105262] [WorldCat] [DOI]
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    Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors. Proceedings of the National Academy of Sciences of the United States of America, 102(24), 8740-5. [PubMed:15939876] [PMC] [WorldCat] [DOI]
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    A genetically encoded ratiometric indicator for chloride: capturing chloride transients in cultured hippocampal neurons. Neuron, 27(3), 447-59. [PubMed:11055428] [WorldCat] [DOI]
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    Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proceedings of the National Academy of Sciences of the United States of America, 98(26), 15003-8. [PubMed:11752449] [PMC] [WorldCat] [DOI]
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    Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proceedings of the National Academy of Sciences of the United States of America, 98(26), 15003-8. [PubMed:11752449] [PMC] [WorldCat] [DOI]
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    Stimulus-specific distinctions in spatial and temporal dynamics of stress-activated protein kinase kinase kinases revealed by a fluorescence resonance energy transfer biosensor. Molecular and cellular biology, 29(22), 6117-27. [PubMed:19737916] [PMC] [WorldCat] [DOI]
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