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コーニション (ソースを閲覧)

2016年2月2日 (火) 13:18時点における版

サイズ変更なし 、 2016年2月2日 (火)
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　コーニションは酵母から哺乳類まで保存されているタンパク質ファミリーである<ref name=ref1><pubmed>16396907</pubmed></ref>。その一部は、イオンチャネル型のグルタミン酸受容体と特異的に結合し、補助サブユニットとしてチャネル活性や細胞膜発現を制御すると考えられている。哺乳類CNIH2/3はAMPA型グルタミン酸受容体と結合しチャネル活性を制御することが<ref name=ref2><pubmed>    19265014</pubmed></ref> <ref name=ref3><pubmed>23522044</pubmed></ref>、線虫ホモログのCNI-1は グルタミン酸受容体GLR-1の局在を調整することが報告されている<ref name=ref4><pubmed>24094107</pubmed></ref>。
　コーニションは酵母から哺乳類まで保存されているタンパク質ファミリーである<ref name=ref1><pubmed>16396907</pubmed></ref>。その一部は、イオンチャネル型のグルタミン酸受容体と特異的に結合し、補助サブユニットとしてチャネル活性や細胞膜発現を制御すると考えられている。哺乳類CNIH2/3はAMPA型グルタミン酸受容体と結合しチャネル活性を制御することが<ref name=ref2><pubmed>    19265014</pubmed></ref> <ref name=ref3><pubmed>23522044</pubmed></ref>、線虫ホモログのCNI-1は グルタミン酸受容体GLR-1の局在を調整することが報告されている<ref name=ref4><pubmed>24094107</pubmed></ref>。
}}
{{GNF_Protein_box
| Name = Cornichon family AMPA receptor auxiliary protein 3
| image =
| image_source =
| PDB =
| HGNCid = 26802
| MGIid =
| Symbol = CNIH3
| AltSymbols =; CNIH-3
| IUPHAR =
| ChEMBL =
| OMIM = None
| ECnumber =
| Homologene =
| GeneAtlas_image1 =
| GeneAtlas_image2 =
| GeneAtlas_image3 =
| Protein_domain_image =
| Function = {{GNF_GO|id=GO:0016247 |text = channel regulator activity}}
| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0005789 |text = endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0012507 |text = ER to Golgi transport vesicle membrane}} {{GNF_GO|id=GO:0030054 |text = cell junction}} {{GNF_GO|id=GO:0032281 |text = AMPA glutamate receptor complex}} {{GNF_GO|id=GO:0033116 |text = endoplasmic reticulum-Golgi intermediate compartment membrane}} {{GNF_GO|id=GO:0043198 |text = dendritic shaft}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0018279 |text = protein N-linked glycosylation via asparagine}} {{GNF_GO|id=GO:0035249 |text = synaptic transmission, glutamatergic}} {{GNF_GO|id=GO:0035556 |text = intracellular signal transduction}} {{GNF_GO|id=GO:0042391 |text = regulation of membrane potential}} {{GNF_GO|id=GO:0043687 |text = post-translational protein modification}} {{GNF_GO|id=GO:0044267 |text = cellular protein metabolic process}} {{GNF_GO|id=GO:0048208 |text = COPII vesicle coating}} {{GNF_GO|id=GO:0061024 |text = membrane organization}} {{GNF_GO|id=GO:2000311 |text = regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity}}
| Hs_EntrezGene = 149111
| Hs_Ensembl = ENSG00000143786
| Hs_RefseqmRNA = NM_152495
| Hs_RefseqProtein = NP_689708
| Hs_GenLoc_db = hg38
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 224434660
| Hs_GenLoc_end = 224740549
| Hs_Uniprot = Q8TBE1
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
| path = PBB/149111
}}
}}


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  | Mm_Uniprot =  
  | Mm_Uniprot =  
  | path = PBB/254263
  | path = PBB/254263
}}
{{GNF_Protein_box
| Name = Cornichon family AMPA receptor auxiliary protein 3
| image =
| image_source =
| PDB =
| HGNCid = 26802
| MGIid =
| Symbol = CNIH3
| AltSymbols =; CNIH-3
| IUPHAR =
| ChEMBL =
| OMIM = None
| ECnumber =
| Homologene =
| GeneAtlas_image1 =
| GeneAtlas_image2 =
| GeneAtlas_image3 =
| Protein_domain_image =
| Function = {{GNF_GO|id=GO:0016247 |text = channel regulator activity}}
| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0005789 |text = endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0012507 |text = ER to Golgi transport vesicle membrane}} {{GNF_GO|id=GO:0030054 |text = cell junction}} {{GNF_GO|id=GO:0032281 |text = AMPA glutamate receptor complex}} {{GNF_GO|id=GO:0033116 |text = endoplasmic reticulum-Golgi intermediate compartment membrane}} {{GNF_GO|id=GO:0043198 |text = dendritic shaft}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0018279 |text = protein N-linked glycosylation via asparagine}} {{GNF_GO|id=GO:0035249 |text = synaptic transmission, glutamatergic}} {{GNF_GO|id=GO:0035556 |text = intracellular signal transduction}} {{GNF_GO|id=GO:0042391 |text = regulation of membrane potential}} {{GNF_GO|id=GO:0043687 |text = post-translational protein modification}} {{GNF_GO|id=GO:0044267 |text = cellular protein metabolic process}} {{GNF_GO|id=GO:0048208 |text = COPII vesicle coating}} {{GNF_GO|id=GO:0061024 |text = membrane organization}} {{GNF_GO|id=GO:2000311 |text = regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity}}
| Hs_EntrezGene = 149111
| Hs_Ensembl = ENSG00000143786
| Hs_RefseqmRNA = NM_152495
| Hs_RefseqProtein = NP_689708
| Hs_GenLoc_db = hg38
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 224434660
| Hs_GenLoc_end = 224740549
| Hs_Uniprot = Q8TBE1
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
| path = PBB/149111
}}
}}


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