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「SNAP-25」の版間の差分
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{{ | {{GNF_Protein_box | ||
| Name = Synaptosomal-associated protein, 25kDa | |||
| image = Protein_SNAP25_PDB_1jth.png | |||
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jth. | |||
| PDB = {{PDB2|1KIL}}, {{PDB2|1XTG}}, {{PDB2|3DDA}}, {{PDB2|3DDB}}, {{PDB2|3RK2}}, {{PDB2|3RK3}}, {{PDB2|3RL0}}, {{PDB2|3ZUR}} | |||
| HGNCid = 11132 | |||
| MGIid = 98331 | |||
| Symbol = SNAP25 | |||
| AltSymbols =; CMS18; RIC-4; RIC4; SEC9; SNAP; SNAP-25; bA416N4.2; dJ1068F16.2 | |||
| IUPHAR = | |||
| ChEMBL = | |||
| OMIM = 600322 | |||
| ECnumber = | |||
| Homologene = 13311 | |||
| GeneAtlas_image1 = PBB_GE_SNAP25_202508_s_at_tn.png | |||
| GeneAtlas_image2 = PBB_GE_SNAP25_202507_s_at_tn.png | |||
| GeneAtlas_image3 = | |||
| Protein_domain_image = | |||
| Function = {{GNF_GO|id=GO:0005484 |text = SNAP receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0017075 |text = syntaxin-1 binding}} {{GNF_GO|id=GO:0048306 |text = calcium-dependent protein binding}} | |||
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005802 |text = trans-Golgi network}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030054 |text = cell junction}} {{GNF_GO|id=GO:0030426 |text = growth cone}} {{GNF_GO|id=GO:0031083 |text = BLOC-1 complex}} {{GNF_GO|id=GO:0031201 |text = SNARE complex}} {{GNF_GO|id=GO:0031982 |text = vesicle}} {{GNF_GO|id=GO:0042734 |text = presynaptic membrane}} {{GNF_GO|id=GO:0043005 |text = neuron projection}} {{GNF_GO|id=GO:0043209 |text = myelin sheath}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}} {{GNF_GO|id=GO:0070032 |text = synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex}} | |||
| Process = {{GNF_GO|id=GO:0001504 |text = neurotransmitter uptake}} {{GNF_GO|id=GO:0006112 |text = energy reserve metabolic process}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007269 |text = neurotransmitter secretion}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}} {{GNF_GO|id=GO:0008306 |text = associative learning}} {{GNF_GO|id=GO:0010975 |text = regulation of neuron projection development}} {{GNF_GO|id=GO:0014047 |text = glutamate secretion}} {{GNF_GO|id=GO:0016079 |text = synaptic vesicle exocytosis}} {{GNF_GO|id=GO:0016081 |text = synaptic vesicle docking}} {{GNF_GO|id=GO:0016082 |text = synaptic vesicle priming}} {{GNF_GO|id=GO:0031629 |text = synaptic vesicle fusion to presynaptic membrane}} {{GNF_GO|id=GO:0044281 |text = small molecule metabolic process}} {{GNF_GO|id=GO:0050796 |text = regulation of insulin secretion}} {{GNF_GO|id=GO:0060291 |text = long-term synaptic potentiation}} | |||
| Hs_EntrezGene = 6616 | |||
| Hs_Ensembl = ENSG00000132639 | |||
| Hs_RefseqmRNA = NM_003081 | |||
| Hs_RefseqProtein = NP_003072 | |||
| Hs_GenLoc_db = hg38 | |||
| Hs_GenLoc_chr = 20 | |||
| Hs_GenLoc_start = 10218830 | |||
| Hs_GenLoc_end = 10307418 | |||
| Hs_Uniprot = P60880 | |||
| Mm_EntrezGene = 20614 | |||
| Mm_Ensembl = ENSMUSG00000027273 | |||
| Mm_RefseqmRNA = NM_001291056 | |||
| Mm_RefseqProtein = NP_001277985 | |||
| Mm_GenLoc_db = mm10 | |||
| Mm_GenLoc_chr = 2 | |||
| Mm_GenLoc_start = 136713453 | |||
| Mm_GenLoc_end = 136782428 | |||
| Mm_Uniprot = P60879 | |||
| path = PBB/6616 | |||
}} | |||
[[image:snap25-1.png|thumb|350px|'''図1．SNARE複合体中のSNAP-25の構造'''<br>SNAP-25のN末側（Qb）およびC末側（Qc）のSNAREモチーフを緑色で、シンタキシン1およびVAMP-2のSNAREモチーフを灰色で示してある。各へリックスのN末端はすべて左側にある。]] | [[image:snap25-1.png|thumb|350px|'''図1．SNARE複合体中のSNAP-25の構造'''<br>SNAP-25のN末側（Qb）およびC末側（Qc）のSNAREモチーフを緑色で、シンタキシン1およびVAMP-2のSNAREモチーフを灰色で示してある。各へリックスのN末端はすべて左側にある。]] | ||