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== == | == == | ||
{| class="wikitable" style="text-align:center" | {| class="wikitable" style="text-align:center" | ||
|+表. | |+表. 多機能カルシウムカルモジュリン依存性タンパク質キナーゼの主要な種類 | ||
|- style="background-color:#ddf" | |- style="background-color:#ddf" | ||
| rowspan="2" | 分類 | | rowspan="2" | 分類 | ||
| rowspan="2" | サブタイプ | | rowspan="2" | サブタイプ | ||
| rowspan="2" | [[ヒト]]における遺伝子名 | | rowspan="2" | [[ヒト]]における遺伝子名 | ||
| colspan="3" | データベース上での遺伝子、タンパク質情報 | | colspan="3" | データベース上での遺伝子、タンパク質情報 | ||
| rowspan="2" | | | rowspan="2" | [[マウス]]脳における発現([[wj:アレン脳科学研究所#アレン脳地図|Allen Brain Atlas]]より) | ||
|- | |- | ||
|- style="background-color:#ddf" | |- style="background-color:#ddf" | ||
33行目: | 31行目: | ||
| [http://www.genenames.org/ HUGO] | | [http://www.genenames.org/ HUGO] | ||
|- | |- | ||
| rowspan=" | | rowspan="4" |'''CaMKI''' | ||
| α | | '''CaMKIα''' | ||
| '' | | ''CAMK1'' | ||
| [http://www.ncbi.nlm.nih.gov/nuccore/NM_001903.2 NM_001903] | | [http://www.ncbi.nlm.nih.gov/nuccore/NM_001903.2 NM_001903] | ||
| [http://www.uniprot.org/uniprot/P35221 P35221] | | [http://www.uniprot.org/uniprot/P35221 P35221] | ||
| [http://www.genenames.org/data/hgnc_data.php?hgnc_id=2509 ID2509] | | [http://www.genenames.org/data/hgnc_data.php?hgnc_id=2509 ID2509] | ||
| [http:// | | [http://mouse.brain-map.org/gene/show/31643 31643] | ||
|- | |- | ||
| & | | '''CaMKIβ''' | ||
| '' | | ''PNCK'' | ||
| [http://www.ncbi.nlm.nih.gov/nuccore/NM_004389 NM_004389] | | [http://www.ncbi.nlm.nih.gov/nuccore/NM_004389 NM_004389] | ||
| [http://www.uniprot.org/uniprot/P26232 P26232] | | [http://www.uniprot.org/uniprot/P26232 P26232] | ||
| [http://www.genenames.org/data/hgnc_data.php?hgnc_id=2510 ID2510] | | [http://www.genenames.org/data/hgnc_data.php?hgnc_id=2510 ID2510] | ||
| [http:// | | [http://mouse.brain-map.org/gene/show/828 828] | ||
|- | |- | ||
| & | | '''CaMKIγ''' | ||
| '' | | ''CAMK1G'' | ||
| [http://www.ncbi.nlm.nih.gov/nuccore/NM_013266 NM_013266] | | [http://www.ncbi.nlm.nih.gov/nuccore/NM_013266 NM_013266] | ||
| [http://www.uniprot.org/uniprot/Q9UI47 Q9UI47] | | [http://www.uniprot.org/uniprot/Q9UI47 Q9UI47] | ||
| [http://www.genenames.org/data/hgnc_data.php?hgnc_id=2511 ID2511] | | [http://www.genenames.org/data/hgnc_data.php?hgnc_id=2511 ID2511] | ||
| | | [http://mouse.brain-map.org/gene/show/828 828] | ||
|- | |- | ||
| '''& | | '''CaMKIδ''' | ||
| ''CAMK1D'' | |||
| '' | |||
| [http://www.ncbi.nlm.nih.gov/protein/NP_001091679 NP_001091679] | | [http://www.ncbi.nlm.nih.gov/protein/NP_001091679 NP_001091679] | ||
| [http://www.uniprot.org/uniprot/P35222 P35222] | | [http://www.uniprot.org/uniprot/P35222 P35222] | ||
| [http://www.genenames.org/data/hgnc_data.php?hgnc_id=2514 ID2514] | | [http://www.genenames.org/data/hgnc_data.php?hgnc_id=2514 ID2514] | ||
| [http:// | | [http://mouse.brain-map.org/gene/show/828 828] | ||
|- | |- | ||
| '''γ | | rowspan="4" |'''CaMKII''' | ||
| & | | '''CaMKIIα''' | ||
| '' | | ''CAMK2A'' | ||
| [http://www.ncbi.nlm.nih.gov/nuccore/NM_001903.2 NM_001903] | |||
| [http://www.uniprot.org/uniprot/P35221 P35221] | |||
| [http://www.genenames.org/data/hgnc_data.php?hgnc_id=2509 ID2509] | |||
| [http://mouse.brain-map.org/gene/show/31643 31643] | |||
|- | |||
| '''CaMKIIβ''' | |||
| ''CAMK2A'' | |||
| [http://www.ncbi.nlm.nih.gov/nuccore/NM_004389 NM_004389] | |||
| [http://www.uniprot.org/uniprot/P26232 P26232] | |||
| [http://www.genenames.org/data/hgnc_data.php?hgnc_id=2510 ID2510] | |||
| [http://mouse.brain-map.org/gene/show/828 828] | |||
|- | |||
| '''CaMKIIγ''' | |||
| ''CAMK2G'' | |||
| [http://www.ncbi.nlm.nih.gov/nuccore/NM_013266 NM_013266] | |||
| [http://www.uniprot.org/uniprot/Q9UI47 Q9UI47] | |||
| [http://www.genenames.org/data/hgnc_data.php?hgnc_id=2511 ID2511] | |||
| [http://mouse.brain-map.org/gene/show/828 828] | |||
|- | |||
| '''CaMKIIδ''' | |||
| ''CAMK2D'' | |||
| [http://www.ncbi.nlm.nih.gov/protein/NP_001091679 NP_001091679] | |||
| [http://www.uniprot.org/uniprot/P35222 P35222] | |||
| [http://www.genenames.org/data/hgnc_data.php?hgnc_id=2514 ID2514] | |||
| [http://mouse.brain-map.org/gene/show/828 828] | |||
|- | |||
| '''CaMKIV''' | |||
| '''CaMKIV''' | |||
| ''CAMK4'' | |||
| [http://www.ncbi.nlm.nih.gov/nuccore/XM_005257316 XM_005257316] | | [http://www.ncbi.nlm.nih.gov/nuccore/XM_005257316 XM_005257316] | ||
| [http://www.uniprot.org/uniprot/P14923 P14923] | | [http://www.uniprot.org/uniprot/P14923 P14923] | ||
| [http://www.genenames.org/data/hgnc_data.php?hgnc_id=6207 ID6207] | | [http://www.genenames.org/data/hgnc_data.php?hgnc_id=6207 ID6207] | ||
| [http:// | | [http://mouse.brain-map.org/gene/show/828 828] | ||
|- | |- | ||
|} | |} | ||
== == | == == | ||
[[ファイル:CaMK domain.png|thumb|right|350px|'''図1. 多機能CaMKファミリーのドメイン構造'''<br>活性調節に重要なリン酸化部位を示す。]] | [[ファイル:CaMK domain.png|thumb|right|350px|'''図1. 多機能CaMKファミリーのドメイン構造'''<br>活性調節に重要なリン酸化部位を示す。]] |